Benfica could dump Juventus out of the Champions League, while Paris Saint-Germain and Chelsea are among the other clubs who can seal a round-of-16 spot on Tuesday.
Juve must win at Benfica to have any chance from qualifying from Group H, while a victory will be enough to see the home side through. They can also advance with a point if Maccabi Haifa are unable to beat PSG.
The Ligue 1 champions will be through with a victory at the Parc des Princes or if they draw and Juve fail to win in Lisbon.
Chelsea travel to Salzburg as the Group E leaders and are guaranteed to progress if they win, while the Austrian side also remain in the hunt to qualify. The Premier League club can also go through if they draw and third-placed Milan defeat Dinamo Zagreb, who are bottom but only three points behind the leaders.
Borussia Dortmund will be sure to join Manchester City in getting out of Group G if they secure a home win over Pep Guardiola's side, who could win the pool with a game to spare. Real Madrid are in a similar situation to City, while RB Leipzig bid to join the holders in the knockout stage.
Ahead of another tense night of action, Stats Perform picks out the standout Opta numbers for the eight matches.
Benfica v Juventus
Juve have lost all three of their European matches away at Benfica, with their most recent loss a 2-1 Europa League defeat in 2014.
The Turin giants only have one victory home or away in the seven previous meetings between the two famous clubs, Jurgen Kohler, Dino Baggio and Fabrizio Ravanelli on target in a 3-0 UEFA Cup clash in 1993.
Benfica could qualify for the knockout stage for a second consecutive season, a back-to-back feat they have only previously achieved in the 2015-16 and 2016-17 seasons under Rui Vitoria.
Juve could be eliminated in the group stage of the Champions League for the first time since the 2013-14 season, when Antonio Conte was in charge.
Paris Saint-Germain v Maccabi Haifa
Maccabi are winless in three away European games (including qualifiers) in France, losing two and drawing in a Cup Winners' Cup tie at PSG back in 1998.
PSG have only lost one of their past 32 group stage games at the Parc des Princes in the Champions League (W25 D6), with their lone defeat during that run coming against Manchester United in October 2020 (1-2). They have averaged 2.7 goals per game in those fixtures, scoring 86.
Since Kylian Mbappe's Champions League debut in September 2016, only Robert Lewandowski has been directly involved in more non-penalty goals (55) than the France forward (54 – 34 goals, 20 assists).
Omer Atzili has scored twice for Maccabi in the Champions League this season. The last Israeli player to net more in a single campaign in the competition was Eran Zahav, who scored three for Hapoel Tel Aviv in 2010-11.
Salzburg v Chelsea
Chelsea have only played two away European matches in Austria, losing 1-0 at Weiner Sport-Club in November 1965 in the Fairs Cup and drawing 1-1 against Austria Vienna in November 1994 in the Cup Winners’ Cup.
Salzburg are winless in all seven of their European matches against English teams (D2 L5), failing to beat Blackburn Rovers (D1 L1), Manchester City (L2), Liverpool (L2) and Chelsea (D1).
In-form Chelsea have won back-to-back Champions League games, beating Milan 3-0 at Stamford Bridge and 2-0 at the San Siro. The last time they won three games in a row in the competition by a margin of at least two goals was in October-November 2013.
Salzburg have scored exactly one goal in each of their past seven games in the Champions League – only one team have ever had a longer run of scoring a single goal in the competition, with Olympiacos doing so in 10 in a row in a run ending in November 2005.
Borussia Dortmund v Manchester City
No player has been directly involved in more goals than City's Erling Haaland (five goals) or Dortmund's Jude Bellingham (four goals, one assist) during the group stage this season.
Dortmund have won just one of their five Champions League matches against City (D1 L3), a 1-0 home victory in the 2012-13 group stage.
No full-back has been involved in more sequences of play that have ended in shots (29) or goals (five) thans Joao Cancelo in the Champions League this season. The Portugal international has provided three assists in four games, equalling his season-best tally in a Champions League campaign (three in nine games last season).
If Haaland scores on his return to face his former club, it will be the third time he has scored in five or more consecutive appearances in the Champions League. Only five players have achieved that feat on three occasions – Cristiano Ronaldo (five), Lionel Messi (three), Lewandowski (three), Zlatan Ibrahimovic (three) and Ruud van Nistelrooy (three).
Other fixtures:
RB Leipzig v Real Madrid
13 – Madrid are unbeaten in their past 13 games against German sides in European competition (W9 D4), scoring at least two goals in every game during this run (31 in total).
3 – Leipzig will be looking to win three consecutive Champions League games for just the second time – they won three in a row between February and August 2020, beating Tottenham twice and Atletico Madrid once.
Dinamo Zagreb v Milan
5 – Dinamo have lost all five of their matches against Milan in European competition (including qualifiers). Against no side have they lost more games in their European history (also five v Ajax).
100 – Milan's 100 per cent record against Dinamo – winning five out of five games against them – is their best against any side in Europe.
Sevilla v Copenhagen
29 – The average age of Sevilla's starting line-up in the Champions League this season is 29 years and 73 days, the second-oldest of any side in the competition this term after Rangers (29 years 96 days).
13 – Copenhagen are winless in all 13 of their major European matches against Spanish teams (D5 L8), losing their last three on Spanish soil.
Celtic v Shakhtar Donetsk
7 – Celtic have lost seven of their past eight games in the Champions League (D1) and are looking for their first win in the competition since September 2017 (3-0 v Anderlecht).
0 – Shakhtar have never won a Champions League away match against a British team, losing on eight of their nine total trips. They did avoid defeat in the most recent one, however, drawing 1-1 against Manchester City in November 2019.
San Jose Earthquakes v Orlando City: Gonzalez certain things will turn
The San Jose Earthquakes may sit bottom of the Western Conference standings ahead of Saturday's clash with Orlando City, but Luchi Gonzalez is certain they will be just fine.
The 'Quakes saw their mini revival halted by a 4-2 loss to the Portland Timbers in midweek, having previously won three straight games across all competitions.
Their 10 points are fewer than all MLS teams except the New England Revolution (seven) have won this season, but Gonzalez has seen positive signs.
"We're going to be fine. This is a great group, and they continue to fight for each other. It's hard when we drop points," he said.
"I expect nothing but a fire in their belly and a response against Orlando and then in the next one, and it's really fun and exciting to coach this team.
"These guys work for each other and they want to keep getting better, and I'm confident they will keep getting better as the season continues."
Orlando have also made a stuttering start, earning 13 points from 12 games to sit 11th in the Eastern Conference standings.
The Lions did shut out a Lionel Messi-less Inter Miami side in a goalless draw on Wednesday, though, and midfielder Wilder Cartagena has seen signs of progress.
"Especially in the last few games, we've been showing ourselves to be more dangerous and attacking," Cartagena said.
"It's similar to how we were in the last half of last year but obviously there are a couple of minor adjustments that we have to make. I think we are playing a lot better in that area."
PLAYERS TO WATCH
San Jose Earthquakes – Amahl Pellegrino
Pellegrino has scored in three straight games, becoming the first San Jose player to do so in MLS play since Cristian Espinoza between July and August last year (four straight).
It's Pellegrino's first time scoring in three straight league matches since he netted in four in a row for Norwegian side Bodo/Glimt in 2023.
Orlando City – Cesar Araujo
Orlando allowed 29 shots against the Philadelphia Union last Saturday but just seven against Miami on Wednesday. It was the first time in their MLS history that Orlando faced at least 20 fewer shots from one game to the next.
Araujo protected the backline admirably in midweek and will look to do likewise again here.
MATCH PREDICTION – DRAW
The home side has never lost in six all-time meetings between San Jose and Orlando.
The first three meetings were all drawn before the hosts won each of the last three, with San Jose winning at home in 2019 and Orlando recording home wins in 2018 and 2021.
After their midweek stalemate against Miami, Orlando have been shut out five times in league play this season. That is tied for the most in MLS in 2024, while their six times being held scoreless in all competitions this term also equals the most by any MLS outfit.
OPTA WIN PROBABILITY
San Jose Earthquakes – 38.4%
Orlando City – 33.4%
Draw – 28.2%
Toronto FC v CF Montreal: Courtois accepts blame amid ongoing winless streak
Laurent Courtois has accepted that it is on him to find a winning formula as CF Montreal look to snap their winless run against Toronto FC.
Montreal were beaten 3-1 by Columbus Crew in midweek and are now without a victory in six games in all competitions.
That includes a three-game losing streak in MLS, leaving them 13th in the Eastern Conference, and Courtois is eager to get back on track.
"It's up to me to find the winning formulas and discern the phases of the game," head coach Courtois said after the loss to Columbus.
"We have to grit our teeth and find solutions. The difficult times we are going through help me identify my group. I want to know the players better.
"From all the negative aspects we can observe, I can identify a few individual aspects to improve the game or the team itself."
Monreal's rivals Toronto have themselves lost back-to-back games ahead of Saturday's Canadian Classique at BMO Field.
Nashville SC scored twice late on to snatch a 2-0 win in the Reds' most recent match, but acting head coach Jason deVos admits there can be no excuses.
"The last ten minutes, two mistakes cost us and that's the cruelty of football sometimes - that it's a 90-minute match and you need to put in a 90-minute performance in," he said.
"The players are aware of that. They know where the growth areas are for us as a team."
PLAYERS TO WATCH
Toronto - Federico Bernardeschi
Bernardeschi missed the loss to Nashville but will hope to start this weekend in a fixture he has fond memories of.
The Italian has scored in each of his two home games against Montreal, making him the third Toronto player to score in two successive home games against them after Jozy Altidore and Michael Bradley.
Montreal - Joel Waterman
Montreal have conceded three or more goals five times across their 12 MLS games this season, which is tied with San Jose Earthquakes for the most in MLS.
They quite simply need to sharpen up at the back, with Joel Waterman needing to step up and hope others around him also do so.. The centre-back led the way for interceptions (three) and clearances (four) against Columbus, yet it was still not enough.
MATCH PREDICTION: DRAW
Montreal have won five successive matches against Toronto, following a run of neither side ever winning more than three on the spin in this fixture.
Toronto have won seven and drawn one of their eight matches in which they have held opponents under two goals since September, while they have lost all 13 in which they have shipped two or more.
Keeping the opposition quiet is therefore key, and this could present a chance to do just that against a Montreal side with fewer points (five) than any side in MLS since mid-March.
OPTA WIN PROBABILITY
Toronto - 39.6%
Draw - 28.5%
Montreal - 31.9%
Al-Nassr 1-1 Al-Hilal: Mitrovic scores last-gasp penalty
Aleksandar Mitrovic scored a penalty in the 10th minute of second-half stoppage time as Al-Hilal denied Cristiano Ronaldo's Al-Nassr victory in a 1-1 draw.
Mitrovic netted his 27th Saudi Pro League goal of the campaign after Sadio Mane was harshly judged to have fouled Saud Abdulhamid in the area.
Mane stuck out an arm to shield the ball, catching his opponent in the throat, though the contact appeared to have been outside of the box.
Mitrovic made no mistake to keep Al-Hilal's unbeaten campaign going.
The Serbian's spot-kick cancelled out Otavio's first-minute opener, with Ronaldo having set up his compatriot.
Champions Al-Hilal remain 12 points clear of Al-Nassr at the summit of the Pro League standings.
Data Debrief: Ronaldo the provider
Ronaldo leads the scoring charts in Saudi Arabia this season, though he had to settle for an assist on Friday.
That came from the only chance he created, with the 39-year-old limited to 25 touches, though he did have four shots.
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