Ollie Robinson has been ruled out of England's series decider against West Indies after failing to recover from a back injury.
The Sussex seamer missed out on the drawn matches in Antigua and Barbados and will play no part in Grenada as England chase a first Test win in nine attempts.
England confirmed their squad on Wednesday, a day before the third Test begins, with Craig Overton recovering from illness to replace Matthew Fisher in the only change.
Robinson was unable to prove his fitness in a net session and skipper Joe Root is hopeful his team-mate can soon put his fitness issues behind him.
"Ollie wasn't as good as we would have liked or he was expecting himself," Root said prior to the squad announcement.
"It's just frustrating for him, as it is for me. He's working very hard but there's something that's nagging away at him.
"I'm not sure exactly of the medical prognosis. He's just got to keep on doing what he's doing and trust in time that he's going to get himself back.
"We all know how effective he has been and how good he's been in his short career up to now so the sooner we can get him back the better."
Root is 116 runs short of reaching 10,000 in Test cricket, a tally only Alastair Cook has previously reached among England players.
The 31-year-old hit centuries in the opening two Tests against West Indies but could not help his side to victory, something he is looking to put right in this winner-takes-all clash.
"I really hope we can take another step forward as a team and get across the line because there's been a lot of good stuff," he told reporters.
"We've played the majority of the cricket up to now and it would be a great way to end the tour. The most pleasing thing is we've not had a nightmare session that's cost us a Test.
"We've looked at each individual session and each hour and looked to win each and every one of them."
England are unbeaten in their last three away Test matches against West Indies, having lost each of the three games prior to that run.
Their most recent meeting at St George's was in April 2015, with England claiming a nine-wicket victory.
'Not a good sign' – Keane unimpressed by Man Utd's injured absentees
Roy Keane was left questioning the attitudes of Manchester United's players as the Red Devils were once again without numerous key players for Sunday's loss to Arsenal.
Bruno Fernandes, Marcus Rashford and Lisandro Martinez were among the notable names to miss out for the 1-0 defeat at Old Trafford, as Erik ten Hag bemoaned continued injury issues.
Martinez and Harry Maguire's absence ensured Ten Hag had to field Jonny Evans and makeshift centre-back partner Casemiro in defence, with the latter at fault for Leandro Trossard's winning goal.
Wayne Rooney vocalised his concerns over the application of United's players and Keane, speaking on Sky Sports, echoed his thoughts as he questioned the prolonged absence of some.
"Obviously, that's not a good sign," Keane said of players not returning from injury. "You'd hope players who are carrying injuries are desperate to get back playing again.
"There is always a worry, there are always players at every club that can drag their heels with an injury.
"Generally, players I played with when they were given a period they'd be injured for, they were always trying to knock a week off it and get back playing for Manchester United or whatever club they're at."
Without a host of key players, United have conceded in 10 successive games in all competitions for the first time since October 2021.
The Red Devils' 82 goals they have conceded this season is their most since 1970-71 (also 82), too, as United continue to disappoint in the 2023-23 campaign.
United have also lost 19 games in all competitions this season, their most since 1977-78 (also 19), while their nine defeats at Old Trafford this term are their joint-most at home in a single campaign.
Keane says the concerns over players not racing back to fitness is not unusual, though it does little to aid Ten Hag's plight.
"It's always a worry but I have to say, it goes on at lots of football clubs," the United great said.
"There are lots of players out there when they have an injury, they're not in the hurry to get back in the team. I think that's obvious and happens at lots of football clubs."
'I don't stop' – Simeone focused after bringing up 400 Atletico wins with Celta triumph
Diego Simeone is refusing to relent in his pursuit with Atletico Madrid after bringing up 400 wins during his managerial tenure at the club.
Atletico needed a late stunner from Rodrigo De Paul to edge past Celta Vigo on Sunday, keeping them on course for Champions League qualification.
Simeone's side would secure a top-four spot in LaLiga if they beat Getafe on Wednesday.
That remains Simeone's firm focus, rather than celebrating personal achievements.
The Atletico boss told reporters: "I don't stop. I know what I want, I know what I'm looking for, I know where the path is.
"I will continue pushing until the last day I am here.
"We will continue game by game until the end, and then we will analyse well what needs to be assessed."
Though not accepting any personal praise, Simeone lauded the support of Atletico's fans after another positive season in the Spanish capital.
"The unconditional support we have with our people," he added. "What is happening this season, our strength at home that is repeated and repeated, and repeated…
"It is not only because of what we can give. There is a passion that is extraordinary, unbeatable in that sense.
"It makes us play with a plus. It exists, it is seen, I hope we can continue repeating it for a long time"
Rooney slams Man Utd players' attitude after Arsenal defeat
Wayne Rooney slammed Manchester United's players after Erik ten Hag made reference to the Red Devils' questionable attitudes following Sunday's defeat to Arsenal.
Ten Hag's side were hammered 4-0 on Monday away to Crystal Palace and followed that up with a 1-0 defeat to Arsenal, leaving them eighth in the league table and three points adrift of the top six.
The United manager was quizzed on the difference between the two performances, suggesting the differing showings had been down to players' "attitude".
Rooney, speaking on Sky Sports, echoed Ten Hag's sentiments as he questioned the application of United's underwhelming performers.
"I've said this a few weeks ago, the players need to look at themselves," the United and England great said.
"When you've got your manager during an interview and he's talking about attitude and attitudes not being right, that is a massive insult.
"If I saw my manager saying that, there is no way I'd let that ride until the end of the season. I feel some players are just trying to get to the end of the season so I feel for him in that way.
"Ultimately, it's his job to make sure the players are right."
Ten Hag has failed to get a tune out of United, dropping out of the Champions League in the group stage and suffering in the Premier League, with their only hope the upcoming FA Cup final with Manchester City.
The Red Devils have lost 19 games in all competitions this season, their most since 1977-78 (also 19), while their nine defeats at Old Trafford this term is their joint-most at home in a single campaign.
United have also conceded in 10 successive games in all competitions for the first time since October 2021, while the 82 goals they have conceded this season is their most since 1970-71 (also 82).
Ten Hag has had to deal with injuries to the likes of Lisandro Martinez, Harry Maguire and Marcus Rashford among others, with Rooney doubling down on his criticism of United's players.
"As we look at the injuries, some of them players can play," the former Everton and Derby County boss continued, with Bruno Fernandes also absent for the Arsenal clash.
"It's easy, you've got a European Championship coming up, an FA Cup final coming up. It's easy for the players, because they're getting a bit of stick now, to stay out for a little bit and come back for the FA Cup final and get ready for the European Championships.
"I've seen it myself over the years, I just think the players who are injured are not filling themselves with any credit at the minute and the manager is going to take all the stick for that."
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