Pablo Carreno Busta saw his title defence at the Hamburg European Open come to an early end as he crashed out on Wednesday, while Andrey Rublev progressed with ease.

Carreno Busta fell to a 6-3 1-6 7-6 (7-5) second-round defeat against Slovakian Alex Molcan, who progressed to a fourth ATP Tour quarter-final this season.

World number 48 Molcan will next meet Borna Coric after the Croatian eased past Tallon Griekspoor 6-3 6-4, registering back-to-back tour-levels wins for the first time in 17 months.

Second seed Rublev coasted through his first-round clash with Ricardas Berankis, triumphing 6-3 6-4 as he improved his record at the ATP 500 clay-court event in Germany to 10-2.

"I am happy with my performance. Ricardas is a really tough player," said world number eight Rublev, who is aiming for his fourth title of the season after success in Marseille, Dubai and Belgrade.

"He hits the ball really hard and plays fast, so I had to bring intensity from the first game. I am really happy with how I was serving today and I hit some great shots from the baseline.

"The game he broke me in the second set he played really well. He returned really aggressively and I don’t think I made one first serve. But then I kept [my] focus and broke him straight away again."

Alejandro Davidovich Fokina was another comfortable winner, easing past Jozef Kovalik 6-2 6-2 to set up a quarter-final contest with Lorenzo Musetti, who beat Emil Ruusuvuori 6-4 7-5.

Play was suspended early at the Swiss Open due to bad weather, with Spaniard Jaume Munar downing Alexander Ritschard 6-3 6-3 in the only match of the day to reach the last eight.

That meant top seed Casper Ruud will have to wait until Thursday to face Jiri Lehecka in Gstaad, with third favourite Roberto Bautista Agut also seeing his match with Juan Pablo Varillas pushed back a day.

Carlos Alcaraz insisted he is not feeling any pressure to be among the Wimbledon favourites after coming through a marathon four-hour clash with Jan-Lennard Struff to reach the second round.

Alcaraz, whose four Tour-level titles in 2022 are more than any other player on the ATP Tour, has been tipped for a deep run at Wimbledon after surging to seventh in the world rankings.

But the 19-year-old was on the brink of a stunning first-round exit when he was taken to a fourth-set tie-break at 2-1 down on Monday, eventually recovering to post a gruelling 4-6 7-5 4-6 7-6 (7-3) 6-4 win on No. 1 Court.

In his post-match media conference, the Spaniard reiterated last week's claim that he is not one of the favourites to triumph in London, although he said he could win the tournament if he plays to the best of his ability.

"I don't feel the pressure because I don't rank myself as one of the favourites to win this tournament," Alcaraz said.

"Obviously if I play well, I have [the] level to win the tournament, but there are a lot more experienced players on grass. I don't feel the pressure."

Alcaraz also conceded his grass-court game can still improve as he hailed his tremendous serving display – which brought him 30 aces, as the reason for his victory.

"I enjoyed [the match] a lot," he added. "Great battle over four hours. For me, [to] play on grass is so beautiful. I like to play on grass. 

"I would say my level on grass has to improve a little bit, but I'm happy with my level.

"I didn't expect to move as well as I did. I mean, I played really well, I felt really well playing on grass and I still don't know how I served [so well].

"This is probably my best match serving. This was a weapon that I used [and] that's why I won – the serve, for sure."

Alcaraz will face Tallon Griekspoor in the second round after the Dutch player overcame Fabio Fognini in four sets on day one.

World number one Daniil Medvedev is through to the quarter-finals of the Halle Open after beating Ilya Ivashka in a routine straight-sets win.   Medvedev only played and defeated the Belarusian six days ago at the Rosmalen Grass Court Championships, and triumphed again as he came through in Germany 7-6 (7-4) 6-3.   After saving three set points to stay in the opening set, Medvedev sealed it on a tie-break, before easing through in the second.   "He is a great player," Medvedev said of Ivashka after the win. "He had a lot of bad luck with injuries at the beginning of the season. At the end of last season he was playing really great tennis.   "I've known him since I was very young, we actually played in Futures, Challengers, and on the ATP Tour. He beat me once in the Davis Cup, which is a really important tournament. So he knows how to play tennis, he knows how to play well on grass, so I'm really happy that two times in a row I managed to pass a tough test."   He will now play seventh seed Roberto Bautista Agut in the last eight after the Spaniard beat Tallon Griekspoor 6-7 (6-8) 6-4 6-2.   Eighth seed Karen Khachanov is also through after defeating Serbian Laslo Djere 7-6 (7-4) 6-4, and will face Oscar Otte after the German overcame Nikoloz Basilashvili 4-6 6-0 7-6 (7-3).

At the Queen's Club Championships, second seed Matteo Berrettini came from a set down to finally see off Denis Kudla, winning 3-6 7-6 (7-5) 6-4.

Defending champion Berrettini was troubled by the world number 82, and was just a tie-break away from suffering an upset, but the Italian came through as he belted down 22 aces in the match.

Berrettini faces Tommy Paul in the quarter-finals after the American beat Stanislas Wawrinka in straight sets, 6-4 6-1.

Ryan Peniston carried on from knocking out number one seed Casper Ruud by beating Francisco Cerundolo 6-0 4-6 6-4, setting up a last eight clash with Filip Krajinovic after he came from behind to defeat Sam Querrey 4-6 6-3 6-4.