Arsenal have been hit by yet another long-term injury blow with defender Laura Wienroither confirmed as having ruptured her anterior cruciate ligament against Wolfsburg on Monday.

After coming off the bench midway through the second half of the Women’s Champions League semi-final leg at the Emirates Stadium, Wienroither then had to be substituted due to injury in the 82nd second minute.

A statement from Arsenal on Thursday said the Austria international had suffered a ruptured ACL, adding: “Laura will undergo surgery in due course and will be sidelined for an extended period.

“Everyone at the club will now be supporting Laura and working hard to support her recovery and return to action.”

It is Arsenal’s fourth ACL injury of the season – after Leah Williamson, Beth Mead and Vivianne Miedema – and skipper Kim Little in March was ruled out for the rest of the campaign by a hamstring issue.

Mikel Arteta insists Arsenal are still gunning for the Premier League title as he praised his squad for refusing to settle for Champions League qualification.

Having topped the table for much of the season, Arsenal slipped from the summit following Manchester City’s 2-1 win at Fulham on Sunday afternoon.

City have now won eight successive league games, including a 4-1 humbling of the Gunners last week which put a fifth title in six years in their own hands.

Conversely, Arsenal have taken just three points from their last four fixtures but their form over the course of the campaign has at least guaranteed a return to Champions League football after six seasons away from Europe’s top table.

While City are now favourites, Arteta will be aiming for a return to form when struggling Chelsea visit the Emirates Stadium on Tuesday night as he refused to rule Arsenal out of the hunt.

“We have achieved what it was difficult to achieve and we can still achieve the Premier league because there are five games to go and a lot of things are going to happen still,” he said.

“Now the title race is not in our hands anymore. What is in our hands is to try to win the games we have left and the rest is down to City.

“What we have to do is forget about what happened last week, learn from it and move on to the next game with a full tilt at home, with our people, London derby, and put things right.

“I know what we were trying to do, what the objective was what we’ve been doing and we still have the nicest part of the season to play with five games to go. But when I still look at it, this is not over.

“I am incredibly proud and thankful to everyone who has contributed to bringing Champions League football back to this club with five or six games to go, it is something that hasn’t happened in over a decade in this football club.

“So congratulations but also thank you for still being upset and not accepting that Champions League is not enough and we want more because this squad is going to demand to get what we want.”

Victory over Chelsea would take Arsenal back to the top of the table for at least 24 hours having led the pack for 247 nights so far this season.

The Blues, having spent a reported £600million on players in the last two transfer windows, are on a run of eight games without a win and have Frank Lampard as interim boss following the sacking of Graham Potter in April.

Arteta, though, believes Chelsea’s plight is proof a club needs more than just a huge transfer budget to be successful.

“In our model we have very important things,” he said.

“First of all, is to have the right people and I think we have the right people. Then we have the right players who can compete, they can challenge, they can understand their role within the team.

“You need quality, goal threat, physicality, you need a lot of things in this game and that is extremely difficult to find that thin balance with the players.

“Recruiting is just… you have the best intention but then the player has to come here, has to fit in, has to get that chemistry with the manager, the team-mates, the staff, the country. It is not easy at all so credit to everybody who makes those decisions as well.

“They have exceptional talent. If they make that work, they can do anything because they have the players, they have the infrastructure they have the history to do it.”

If a statement win was what Manchester City were after against Arsenal on Wednesday, then they got it.

City thrashed the Premier League leaders 4-1 at the Etihad Stadium to close the gap to the Gunners to two points, and Pep Guardiola's side still have two games in hand.

The reigning champions play again on Sunday, with a trip to Fulham on the cards. Arsenal, meanwhile, are next in action on Tuesday, when they host struggling Chelsea, who have lost every game under interim boss Frank Lampard.

At the other end of the table, Leicester City face Everton in a relegation six-pointer. In the race for Europe, Tottenham travel to Liverpool.

Fulham v Manchester City

City have won their last 13 meetings with Fulham in all competitions, only winning more consecutively against Watford (15 – 2013-2022) and West Brom (14 – 2012-2018) in their history.

Erling Haaland has scored 33 Premier League goals for Manchester City this season, a record in a 38-game season. He is one away from equalling the overall record for a single season, set by Andrew Cole in 1993-94 and matched by Alan Shearer in 1994-95 (34 goals) in 42-game campaigns. This will be his 30th appearance in the competition, with his 33 goals already more than 21 teams managed in total in their first 30 Premier League games.

Pep Guardiola has won 25 of his 38 Premier League away games against London sides, the highest win rate of any visiting manager to take charge of at least 10 such games (66 per cent). All eight of his defeats in the capital have come against either Tottenham (five) or Chelsea (three).

Best bet – City to avoid defeat: Fulham are winless in their last 15 Premier League meetings with City (D3 L12) since a 3-1 away win in April 2009. They have lost the last 10 in a row by an aggregate score of 28-4.

Long shot – Fulham to keep a clean sheet: Fulham have kept just one clean sheet in their 29 Premier League games against City, a goalless draw in March 2004. 

Opta prediction: City, as expected, are made big favourites (64.8 per cent). The draw is rated at 21.9 per cent, while Fulham are given a 13.3 per cent chance of victory.

Liverpool v Tottenham

Liverpool have lost just one of their last 20 Premier League games against Spurs (W13 D6) and are unbeaten in 10 since a 4-1 loss at Wembley Stadium in October 2017.

Tottenham are winless in five Premier League away games, losing as many games in this run (three) as they had in their previous 16 on the road beforehand (W8 D5). It is their longest run without an away league win since a run of 12 between February and November 2019.

Liverpool have won their last three Premier League matches, despite conceding in each match. The last time they won four games in a row was in November and December earlier this season, also conceding in all four victories.

Best bet – Mohamed Salah to score or assist: Salah has been involved in 11 goals in his last eight home games in all competitions (eight goals, three assists), scoring at least once in each of his last six. Since he joined Liverpool in 2017, no player has scored more Premier League goals against Tottenham than the Egyptian (seven).

Long shot – Liverpool under 1.5 goals: Tottenham have conceded 31 away goals in the Premier League this season, already their most in a single campaign since 2008-09 (35). They have only kept two league clean sheets outside of London this season, doing so in victories at Nottingham Forest (2-0) and Brighton and Hove Albion (1-0).

Opta prediction: The supercomputer hands Liverpool a 55.2 per cent probability of winning this one, while Spurs are given just a 20.0 per cent shot. The draw has a 24.8 per cent likelihood.

Leicester City v Everton

Following their 2-0 win at Goodison Park in November, Leicester are looking to complete a Premier League double over Everton for just the second time, previously doing so in their 2015-16 title winning campaign.

Everton have won their last two Premier League away games against Leicester – they have never won on three consecutive visits to the Foxes in their league history.

Dean Smith has won four and lost none of his six Premier League meetings with Everton, winning three of his four at home against the Toffees. Only Antonio Conte (seven) has faced Everton more without ever losing to them as a manager in the competition.

Best bet – Leicester to concede: Despite Everton's woeful form in front of goal this season, they should be confident of getting on the scoresheet, given Leicester have conceded in each of their last 18 Premier League games, their joint-longest run without a clean sheet in the competition. 

Long shot – Everton to win: Everton are winless in their last 12 Premier League away games (D5 L7). Since beating Brighton 2-0 in August 2021, they have won just two of their last 33 away league games (D10 L21).

Opta prediction: Everton won this fixture last season, but Opta does not give them much chance of repeating that feat on Monday. Their chances of victory are rated at only 21.8 per cent, while the draw is 26.3 per cent, making Leicester (51.9 per cent) the clear favourites.

Arsenal v Chelsea

Arsenal have won four of their last five Premier League games against Chelsea (L1), as many as they had in their previous 23 against the Blues (D6 L13).

The Gunners are looking to win three consecutive Premier League games against Chelsea for the first time since February 2004. Indeed, they could achieve their second league double in three seasons against the Blues, having done so just once in the previous 20 campaigns beforehand (2003-04).

Chelsea have lost all five matches in all competitions since Lampard's return to the club, their worst losing run since a six-game run in October and November 1993. The Blues have lost 19 games in total this season, last losing 20 in a single campaign in 1987-88.

Best bet – Bukayo Saka 2+ shots on target: Saka has been directly involved in 16 goals in his 16 Premier League home games this season (nine goals, seven assists). He has both scored and assisted a goal in three different games at Emirates Stadium in the competition this term.

Long shot – Arsenal to fail to score: Only Southampton have kept fewer home clean sheets than Arsenal (three) in the Premier League this season. However, the Gunners have only failed to score in one of their 16 at the Emirates so far this term (0-0 vs Newcastle United in January).

Opta prediction: Arsenal have had a wobble that might prove costly in the title race but will be determined to bounce back. Opta makes them the favourites (43.5 per cent), with Chelsea at 28.2 per cent. The draw is rated at 28.3 per cent.

The Premier League title race is "not over" for Manchester City and Arsenal, but ex-player Kolo Toure acknowledged the reigning champions hold the advantage.

Pep Guardiola's side ruthlessly dismantled Arsenal in a 4-1 win on Wednesday, to move two points off the Gunners at the summit with two games in hand.

After dropping points three games on the bounce before their loss to the champions, Arsenal's hopes of a first title since 2004 look to have slipped away.

But Toure, who won Premier League titles with both clubs across his career, feels it cannot be called until the final day of the season, despite City's ascendancy.

"It is not over yet," he told Stats Perform. "There are still some games. [It was a] big statement from City. They showed their qualities, they showed their mentality.

"They showed that they want to win the Premier League. From the start of the season, they have always been the favourite to win it, but [there are a] few games to go.

"Arsenal have been doing very well this season. Challenging City is always really, really hard because of the manager, because of the depth of the team they have.

"But Arsenal are surprising everybody and until the last game, you cannot say that league is done. As soon as you have one mistake, and you lose one game, everything changes in your mind.

"The pressure starts again. That's why, for Arsenal, it's very important that they stay on it. They have to make sure they don't make any mistakes to keep the pressure on City."

Arsenal had been considered rank outsiders for the title in pre-season, but until their recent dip, looked in a commanding position to push on and secure victory.

A slew of draws with Liverpool, West Ham and Southampton have cost them dearly however, with the defeat to City taking matters out of their hands.

Toure disagrees with the idea Arsenal have choked from the pressure however, and believes the Gunners have shown exceptional growth under Mikel Arteta to even be in the conversation.

"It's very harsh [to say so]," he added. "That's harsh because no one expected Arsenal to do what they are doing. Until the season is over, it's not over.

"I would say they're on the right road and the right track, because Arsenal have been suffering for a few years with some of their results. Arteta came, he did a great job.

He has put the club on the right path now. They just have to believe in him, they just have to carry on with what they're doing. I believe they are on the right track.

"[If they] stay calm, keep doing the process, keep putting pressure on those immense clubs like City, like Liverpool, then there is a moment where your time will come to shine."

Arsenal next face a London derby with struggling Chelsea on Tuesday before a clash with top-four rivals Newcastle United a week on Sunday.

Pep Guardiola has warned Arsenal will not give up on their bid to deny Manchester City a third successive Premier League title.

After a Kevin De Bruyne-inspired City thrashed Arsenal 4-1 on Wednesday, Guardiola's men sit two points behind the faltering leaders with two games in hand.

Arsenal are not in action again until they host Chelsea on Tuesday, meaning City have the opportunity to go top of the table when they visit Fulham on Sunday.

With Arsenal only taking three points from their last four league games and City winning their last seven, some have declared the title race to be over, despite the Gunners leading the way.

Guardiola, however, is adamant City still have work to do.

Asked about the importance of going top at Friday's pre-match press conference, Guardiola said: "Psychologically, it's important, but its more the fact it depends on us, we don't have to look at anything except performing as well as possible to win games.

"People start saying they have a feeling that it's over. It's not over. It will be over when it's over. In every single game, our opponents play for special things.

"I know what happened when we played at the Emirates, we won and everybody was happy, people saying we had already caught them. Then we went to Nottingham Forest and drew – it was a fantastic game, but we drew.

"If we do our job, we will be close. But we'll take nothing for granted. We're happy, of course, for the last few games, but that's all.

"I know it's not 20 games left, it's seven games. But seven games is seven games, it's a lot, considering we have the Champions League around the corner."

Arsenal's chastening defeat at the Etihad Stadium was the Gunners' 12th in succession against City in the top flight, with Guardiola's men winning those matches by an aggregate score of 33-5.

While that result has the potential to be a knockout blow after Mikel Arteta's team were held by Liverpool, West Ham and Southampton, Guardiola believes Arsenal could yet fight back.

"I know Mikel perfectly, I think our players know it – they will not give up," he said. "One of their real prizes – to be in the Champions League next season – is done. They will not give up.

"When you are 10 points in front you can say it's over, but the reality today is we are two points behind. 

"You say we have two games in hand, but we have to be respectful to the teams we have to play, West Ham and Brighton. We have to beat them. If we beat them, I will agree with you, but we still have to play.

"If the championship finished today, they are champions. It's normal, this tendency, because of what we have done in the past, and Arsenal have not been there for a long time. 

"What happened to Arsenal in the last four games can happen to us. People say it's impossible, no. It's possible."

Chelsea are reportedly investigating a potential transfer for Sadio Mane after the forward's highly publicised bust-up with Bayern Munich team-mate Leroy Sane.

Mane, 31, won the Premier League and Champions League with Liverpool before joining Bayern in a £27million (€32m) transfer in June.

His first season in Germany has resulted in 10 goals and five assists in his 30 combined appearances in the Bundesliga and Champions League, making 22 starts.

While he has been far from a disappointment, his future at the club is now up in the air after a widely reported incident where he punched his team-mate after a 3-0 Champions League defeat against Manchester City.

TOP STORY – CHELSEA TO OFFER MANE A RETURN TO THE PREMIER LEAGUE

According to Football Insider, Sadio Mane "is now believed to be on the radar of Chelsea", and the Stamford Bridge club are now "ready to consider a shock move".

The report states Bayern will only be looking to recoup the majority of the fee they paid for the Senegalese star, and would provide a far cheaper alternative to Napoli's 24-year-old sensation Victor Osimhen.

It also adds that Mane's former club Liverpool have no interest in bringing him back to Anfield.

ROUND-UP

– The Telegraph is reporting that West Ham's 24-year-old midfielder Declan Rice is Arsenal's top priority in the next transfer window.

– Aston Villa are planning a bid for 27-year-old Brentford striker Ivan Toney, who also has interest from Manchester United, per Football Insider.

– According to Gazzetta dello Sport, Milan would like to secure 30-year-old Atletico Madrid striker Alvaro Morata as a replacement for injury-prone veteran Zlatan Ibrahimovic.

– Former Chelsea boss Thomas Tuchel wants to reunite with 28-year-old midfielder Mateo Kovacic at Bayern Munich, per Sport1.

Bernardo Silva has described Kevin De Bruyne and Erling Haaland as “beasts” after the destructive duo ran riot in Manchester City’s vital win over Arsenal.

De Bruyne scored twice from Haaland assists and then made another for John Stones before the Norwegian got on the scoresheet in a 4-1 win at the Etihad Stadium on Wednesday.

The victory put the treble-chasing champions in firm control of the Premier League title race as they moved within two points of the leaders with two games in hand.

Haaland has now scored a stunning 33 goals in the competition this season – one short of the record – and laid on seven assists while De Bruyne’s figures are seven and 16 respectively.

City midfielder Silva said: “We knew that they could come doing man-to-man and we tried to stretch them as much as possible because, if they do man-to-man against us, they have to deal with Kevin and Erling up front. It’s never going to be easy in that spot.

“It was perfect for Kevin. They gave space for Kevin and to Erling to run. When you give them this kind of space, they are so difficult to defend.

“Two beasts running, their movements – Kevin with the passes, Erling with the scoring – this was the opposite.

“They did it perfectly, they created lots of chances. We could have scored even more.”

City now have a superb chance to emulate Manchester United’s 1999 achievement of winning all three of the remaining trophies on offer.

As well as being in command of their title destiny they are through to the FA Cup final, where they will face United, and they take on Real Madrid in the last four of the Champions League next month.

Manager Pep Guardiola has been reluctant to publicly discuss the prospect of winning the treble.

Silva insists the subject is not off-limits but the focus is very much on taking one game at a time.

The Portuguese said: “No, he hasn’t banned anything! We’re big men and we talk about whatever we want.

“But these players know that the best way to achieve good things is to think just about the next one. If we don’t beat Fulham on Sunday we put ourselves in a difficult position to win the Premier League.

“If we don’t win the Premier League we arrive in the final of the FA Cup and in the semi-finals of the Champions League not in a good momentum.

“We want to try and stay in this good momentum to try and go as far as possible. The team is doing very well at the moment and we’re going to try and keep it that way.”

Barcelona's determination to bring Lionel Messi back to Camp Nou is going to be a major storyline during the next transfer window.

But their pursuit of the 2022 World Cup winner is complicated given the Blaugrana's financial situation.

As a result, Barca's squad are on notice, with expectations that key players may need to be offloaded.

TOP STORY – PREMIER LEAGUE TRIO TO SWOOP FOR RAPHINHA

Raphinha is set to be sold by Barcelona in the off-season with three Premier League clubs circling for his signature, according to reports.

The Blaugrana will need to let Raphinha go to free up space for Messi to return given the club's financial issues, claims Fichajes. Messi is out of contract at Paris Saint-Germain at the end of this season.

Raphinha joined from Leeds United last year and his stay could be short. AS claims Arsenal, Tottenham and Newcastle United are all interested in the 26-year-old.

ROUND-UP

– Milan forward Rafael Leao has declined offers from both Real Madrid and Chelsea, claims La Gazzetta dello Sport.

– Dinamo Zagreb goalkeeper Dominik Livakovic is drawing interest from Manchester United , according to Croatian outlet Jutarnji, with the Red Devils uncertain on David de Gea 's future.

– Chelsea are tracking Brentford pair David Raya and Ivan Toney, reports Football London.

– Football 365 claims Aston Villa are circling for Emile Smith Rowe,  who is "disappointed" with his lack of game time at Arsenal.

– Leicester City defender Caglar Soyuncu's planned move to Atletico Madrid is signed and sealed, according to Fabrizio Romano. The Turkish defender's contract will run until 2027.

– Sky Germany's Florian Plettenberg claims Yann Sommer could leave Bayern Munich in the off-season, with new head coach Thomas Tuchel set to restore Manuel Neuer to the side when he returns to full fitness.

Pep Guardiola insisted there was nothing decisive about Manchester City’s 4-1 win over Premier League rivals Arsenal but acknowledged something big had shifted with the title now in his side’s hands.

City made light of a fixture long billed as a high-pressure title decider, with the dynamic play of Kevin De Bruyne and Erling Haaland ripping through the Arsenal defence time and again.

City scored four – Haaland netting the last after twice setting up De Bruyne, who in turn got the assist on a John Stones header – but could have exceeded that in the first half alone on a dominant night. Rob Holding’s late goal was slim consolation for the Gunners.

Arsenal still ended the night top of the table, but their two-point advantage looks particularly vulnerable with a City side who have won seven in a row in the league boasting two games in hand.

“It was an important game, not decisive but important,” Guardiola said.

“We played very good. I know the opponent we played. They’re still top, I know it sounds naive what I’m saying but we are still behind. We are still there.”

With the exception of a few days in February after City won 3-1 at the Emirates, Arsenal have topped the Premier League table since the third week of the season.

City have been playing catch up all along with Guardiola calling Arsenal the favourites for the title, but this result convinced the Catalan he and his side are finally in the stronger position.

“Absolutely (I prefer) my position because now it’s in our hands,” he said.

“I would love that these two games are six points but you have to win them, but I prefer it because it depends on us.

“Until today, I prefer the position in the Premier League of Arsenal because if Arsenal had beaten us it’s in their hands. But now it is in our hands.”

For Arsenal this was a fourth straight game without a win, with the Gunners appearing to wilt just as City turn up the heat.

Mikel Arteta admitted his side were second best on the night and might now end up second best in the league, but refused to admit defeat in a title race his side still lead, at least for now.

“The analysis is clear,” Arteta said. “The better team won the game. They were probably at their best, especially in the first half, and we were nowhere near our level. When that happens the gap becomes too big.

“The first 30 minutes all the basic things you have to do against an exceptional team in terms of competing, winning duels, understanding what the game requires, we didn’t do it and we were punished.

“The stats said Arsenal were going to finish sixth or seventh and we are where we are with five games to go. Those players deserve a lot of credit after nine-and-a-half months being here. And there are still five games to play.

“In 22 years in this country I’ve seen a lot of things and there are not two equal games in this league.”

Arsenal have five games remaining and Arteta admitted they would need to win them all – something that would put them on 90 points – to take the challenge to City.

“We first have to lift the players up tonight because they suffer and it was difficult to swallow,” he said.

“Do everything we have done so well in the next match to earn the right to win it. That’s where we have to start.”

Mikel Arteta will not go down without a fight despite seeing his Arsenal side carved apart by a rampant Manchester City.

Kevin De Bruyne, John Stones and Erling Haaland were on target as Pep Guardiola's side claimed a 4-1 win over the Gunners on Wednesday.

City are now just two points behind the Premier League leaders with two games in hand.

Following City's win, they now have a 92 per cent chance of winning the league, compared to just eight per cent for the Gunners, according to Opta.

Arteta, however, is not giving up hope.

"It's a very difficult night, obviously after the way we lost," he told BT Sport.

"But we have to stand up, look at the bigger picture and the way we are competing toe-to-toe with this team. It's incredible, to be fair, and we want to compete, we're not going to give up.

"There's five games to go, anything can happen and I've seen a lot of things happen over 20 years. You have to believe that, we have to look in the mirror and accept that we have lost against an exceptional team."

City were brilliant throughout.

De Bruyne put them ahead after just seven minutes, before teeing up Stones to add a second on the stroke of half-time.

De Bruyne's second wrapped matters up early in the second half, with Rob Holding striking a consolation before Haaland got in on the act, surpassing Mohamed Salah's record of 32 goals in a 38-game Premier League season in the process.

"We were beaten by the better team, that's for sure," said Arteta.

"They were exceptional and when that's the case, it's difficult to reach that level, and we were nowhere near our level, especially in the first half – when you open that gap, you get punished.

"When you have it in one corner and they kick it 60 yards, they win that duel, they run through you – you have to start competing, winning your duels and all the basic things. We didn't do them in the first half.

"The way we were in the first 20, 30 minutes, they were on top of us, we could not handle the situation. They were being extremely direct, we knew they had the capacity to do that because they can stretch the pitch. We had to compete but we lost it straight away."

Pep Guardiola was adamant that the next three games will dictate the title race after Manchester City's commanding 4-1 home victory against Arsenal saw them take charge of the Premier League. 

City remain in second place and two points behind Arsenal but, with two games in hand over their London rivals, have wrestled the momentum into their own hands with just seven games to go.

A brace from Kevin De Bruyne alongside goals from John Stones and Erling Haaland cemented a dominant home display from Guardiola's side, but the City manager was quick to turn the attention to the crucial fixtures ahead as City look to take advantage of their games in hand over their London rivals.

"I know the next three games are really important," he said speaking to BT Sport.

"Fulham on Sunday, what Marco Silva has done this season is incredible, and then after the two games at home against West Ham and Leeds, these games will dictate the season.

"The reality today is we are behind Arsenal, they are two points in front of us."

Guardiola went on to laud the dominant manner of his side's victory who have now won 12 consecutive league games against Arsenal. 

"From the first minute we were incredibly focused," Guardiola said. 

"The guys responded unbelievably in an important game – not decisive, but really important.

"We are back-to-back Premier League winners so in September, October, when you lose a game you say you have time, but Arsenal were not like that. When we arrive in the last two months, the players know it’s close and if we lose, we have no chance.

"As a player, playing with that mentality that there is no other option but to win, that is the best way to approach the games. In the last two months, the players showed that every game we try to win and move forward."

Stones', whose header provided City's crucial second goal on the stroke of half-time, suggested that the experience of City's squad was a key factor in the crucial victory.

He said: "We've been through tough moments and situations at this stage of the season in the past, and it's done us so well - we know how to cope and what to do in different scenarios.

"Everyone's been there and everyone has that hunger. Day's like today there is a lot of pressure from the outside, but we know our jobs and what is asked of us on the pitch and that experience helps in those big pressure moments."

Guardiola will now look to guide his side to their fifth league title in six years and heralded the support from the club's board as well as the quality of his players for his remarkable success at the Manchester club. 

"This club gave me everything, from the hierarchy," he said.

"I remember the first season when we didn’t win, they supported me unconditionally. We were lucky as a team with how the way Liverpool pushed us in the previous seasons and this season, Arsenal – they got 50 points in the first half of the season. We want to win, why should we stop, it’s not necessary.

"I’ve been at Barcelona, Bayern Munich and Manchester City. The incredible qualities of the players I have had at my disposal – it’s work ethic, the rest is quality."

Champions Manchester City produced a stunning performance to seize complete control of the Premier League title race with a devastating 4-1 win over leaders Arsenal.

Kevin De Bruyne struck twice with John Stones and Erling Haaland also on the scoresheet at the Etihad Stadium as City delivered a potentially decisive blow to the Gunners’ hopes of lifting the crown.

Arsenal claimed a late reply through Rob Holding but treble-chasing City had long since asserted their dominance and Haaland wrapped up the contest with his 49th goal of the season in stoppage time.

The result lifted Pep Guardiola’s men to within two points of the Londoners at the top of the table and, with two games in hand, they are now strong favourites to land their fifth title in six years.

Arsenal and their manager Mikel Arteta simply had no answer to the pace, strength and determination of the hosts, who were at their ruthless best and powered to their 12th win in their last 13 games in all competitions.

Manchester City took the Premier League title race into their own hands with a 4-1 demolition job of leaders Arsenal on Wednesday.

Three straight draws saw Arsenal hand City the initiative before the Gunners' trip to the Etihad Stadium, and Pep Guardiola's side showed little mercy in a stunning display of dominance.

Kevin De Bruyne came to the fore, scoring either side of John Stones' header, which City's playmaker teed up.

Rob Holding snatched a consolation late on, but Erling Haaland ensured he had the last word with a goal that saw him break the record for goals in a 38-game Premier League season, as City made their point.

City were convinced they should have had a penalty inside three minutes, yet De Bruyne was adjudged to have fouled Thomas Partey after Aaron Ramsdale fumbled Jack Grealish's cross.

De Bruyne was wheeling away in celebration soon after, though. Having latched onto Haaland's superb touch, the Belgian beat Ramsdale with a sublime finish into the bottom-right corner. 

White and Ramsdale denied De Bruyne and Haaland respectively as City hunted a second, before the latter drilled wide at the end of a menacing run.

Ramsdale thwarted Haaland again, but Arsenal's resolve was punctured for a second time on the stroke of the interval – Stones heading home from De Bruyne's pinpoint free-kick, with the goal awarded after a VAR check on the linesman's offside call.

Haaland's battle with Ramsdale continued after the break, and Arsenal's goalkeeper again came out on top with a superb one-on-one save.

But Haaland turned provider for City's third in the 54th minute, playing a slick one-two with De Bruyne, whose crisp finish flashed beyond Ramsdale.

Partey lashing out at Grealish's taunts was as close as Arsenal came to laying a glove on City before Holding curled home with four minutes remaining.

Haaland, though, got his goal with the final kick of the game, as City emphatically took matters into their own hands.

Pep Guardiola does not believe Wednesday's clash with Arsenal will decide the outcome of the Premier League title race but wants Manchester City to take destiny into their own hands.

City, who have booked their place in the last four of the Champions League and the FA Cup final, will move within two points of Arsenal, with two games in hand, should they beat the Gunners at the Etihad Stadium.

Arsenal have drawn their last three league games, while City have won 11 of their previous 12 outings across all competitions.

Asked if there was a reason behind City's menacing form, Guardiola told reporters: "When, early in the season, we lost games, people said it was physicality, that it was not good – that is, bulls***.

"Many things are involved in a game. We know now if we lose games, the situation will be over, so that's why when you are in October, November, you cannot have that feeling, especially after back-to-back championships.

"In the year when we won our first title [2017-18], when we got 100 points, we started the season like every game is a final.

"When we started this season after back-to-back Premier League titles, we did not have that feeling, every game was not a final. Now it is.

"Now we have arrived with the chance in our heads. If Arsenal win, the destiny is in their hands, but if we win, the destiny is in our hands."

On whether Wednesday's encounter was the decisive game in the title race, Guardiola said: "It's really important. Not decisive because still many tough games for both sides but we cannot deny how important it is.

"When you play these kind of teams, it is about everything. Arsenal have always had incredible details and care on the ball, all the players they select to play for the club have the biggest quality, biggest skills.

"Mikel [Arteta] has brought another dimension, they are big competitors, so aggressive. They control a lot of aspects. This isn't anything new. In the two games we've played this season, we felt it, and you have to challenge them or with the speed, intensity they have and quality they have in the build-up, it's difficult."

Arteta said his team will need to be "perfect" to beat City, though Guardiola does not see perfection as being attainable.

"Perfection doesn't exist in football, you cannot be perfect in the game," he said. "We know what happened against Bayern Munich and in the future against top teams, your standard has to be really high.

"They demand to be really good, so we have to do what we can to impose our game."

Mikel Arteta reminded Manchester City that Arsenal still hold top spot in the Premier League and will not let relinquish it without an almighty fight as the top two prepare for an Etihad Stadium battle.

The Arsenal manager explained how City old boys Oleksandr Zinchenko and Gabriel Jesus have been adamant the Gunners are title material since joining in the close season.

That has helped to feed positivity around the team, and it remains in place despite Arsenal drawing their last three games to allow second-placed City to narrow the gap.

Arsenal's lead stands at five points, with City having two games in hand, plus Pep Guardiola's team have home advantage on Wednesday.

Defender William Saliba misses out through injury, and Granit Xhaka is a doubt, and Arteta is wrestling to get the best out of a team who have been paying for errors in recent weeks.On the eve of the game, Arteta said his players should still believe.

"One hundred per cent," Arteta said. "But we knew from the beginning that City were the team to beat, probably with Liverpool because of what those teams have won in the last six, seven years.

"We were the ones that wanted to be closing that gap as much as we possibly could.

"We are toe-to-toe with them. We knew we had to go to the Etihad. We know that after that we have another five difficult games.

"That game is going to be really important, but is it going to define the season? The answer is no.

"If we win tomorrow night, we haven't won the league that's for sure. It will shift a little probably, the percentage, but five games in this league with the games we still have to play, very tricky still.

"The belief is there. We really want it, and we're going to show that again tomorrow night. But then you have to deliver in the right moment, the right performance, and it has to be perfection.

"It's going to be a tough night and challenge, but the opportunity is incredible for us. We knew from the beginning that if you want to win the Premier League you have to go to Spurs and you have to beat them. You have to go to Chelsea and beat them. This is what we've been doing, and that's why we are here.

"Now we go to City, and we have to beat them. If you want to be champions you have to win those matches, it's as simple as that."

It helps that Arsenal have title winners in Zinchenko and Jesus within their ranks.

"For sure. The experience is key when you've been in those moments, to handle those moments and understand the importance of certain things," Arteta said.

"When they came in, after two or three weeks they said we can win the league. It's been going on since August. This process has been coming for a long time."

Arteta, a former assistant coach at City, said he has not spoken to Guardiola recently, and it will be pure business between the former colleagues on Wednesday.

Arsenal need to stop Erling Haaland, but they will be aware threats come from all quarters with City, exemplified by Riyah Mahrez hitting an FA Cup semi-final hat-trick at the weekend.

"Obviously we are working on their threats as well as working on their weaknesses, and we know what they are," Arteta said. "You have to control every single one.

"Let's focus on us. We know what they want to do, what they're going to try to do. They can do so many things. You have to focus on certain principles to try to take the game where you want."

Reminding his players of their position, Arteta pointed to Arsenal still being firmly in the race for the title, even as the focus shifts to City's recent scorching form.

"They build up this incredible form and look where we are in the table still, so that means we've been as well in incredible form, and that's why we are where we are," the Arsenal boss added.

Looking at the challenge of handling Haaland, the Premier League's 32-goal top scorer, Arteta said: "When you look at the numbers, there's no comparison with anybody else. He's able to produce that because the set-up is done in the right way for him. Preventing the source is something that is probably the best recipe."