The neutral has plenty to be thankful for in this thrilling 2021 NFL season.
But all that drama, driven by a series of stunning against-the-odds upsets, can make life miserable for fantasy players, even at this celebratory time of year.
Want to maintain your cheer through another seemingly unpredictable slate of games this Thanksgiving week? Turn to Stats Perform for the below data-powered picks.
Quarterback: Jalen Hurts, Philadelphia Eagles @ New York Giants
The Eagles head into Week 12 rejuvenated, having won three of their past four games to improve to 5-6 ahead of a big NFC East matchup. Those three wins have all had one thing in common: Philadelphia have exceeded 200 yards rushing.
This run-heavy approach – with a league-high 49.6 rush percentage – wisely plays to the strengths of quarterback Hurts, who had three rushing scores last week against the New Orleans Saints as he surpassed 50 yards on the ground for the fifth straight game.
That was Hurts' 15th QB start. He ranks second through 15 QB starts since 1950 for rushing touchdowns (11 – behind Cam Newton, 14) and second through 15 QB starts since 1960 for rushing yards (890 – behind Lamar Jackson, 1,193).
The Giants – reeling from a bad defeat to the Tampa Bay Buccaneers – have given up 4.38 yards per rush play, ranking a mediocre 19th, and have not yet played any of the six best offenses in that regard. The Eagles' offense (4.99 yards per rush), led by Hurts, sits third and will be eyeing further big gains.
Running back: Joe Mixon, Cincinnati Bengals vs. Pittsburgh Steelers
Mixon is already enjoying a career year with nine rushing TDs, and the 2021 season might be about to get a whole lot better for the running back – and any fantasy players who can count on him – as the Bengals face an injury-ravaged Steelers defense.
Pittsburgh have now given up the most yards per rush play (4.76) after a tough two weeks in which their roster was hit by absences and it showed on the field. The winless Detroit Lions tallied 229 rushing yards and two TDs in their Week 10 tie, before the Los Angeles Chargers averaged 6.12 yards per rush as Austin Ekeler's two scores headlined a Week 11 win.
Mixon, who has rushing TDs in four straight games and last week ran for over 100 yards for the first time since Week 1, should get free rein against a Steelers defense that successfully disrupts the run on just 24.62 per cent of attempts.
Even if Pittsburgh can fix a problem that has persisted throughout the season and got worse of late, Mixon ranks 12th among running backs (min. 10 carries) with 3.74 yards per carry on disrupted runs.
Wide receiver: Deebo Samuel, San Francisco 49ers vs. Minnesota Vikings
A significant shift towards a run-heavy approach – the 49ers averaged 25.6 rushes per game through Week 9 but 43.0 per game since – would be an issue for most wide receivers, but Samuel is not most wide receivers.
It is his versatility that has helped accommodate a change that has potentially brought San Francisco back into contention.
Samuel caught only one pass against the Jacksonville Jaguars last week but rushed for 79 yards and a TD in the absence of injured rookie Elijah Mitchell. The previous week, with Mitchell involved against the Los Angeles Rams, Samuel had rushing and receiving scores in the same game for the first time in his career.
With the Vikings' rush defense matching the Steelers' in giving up 4.76 yards per rush, expect Samuel and the Niners to run the ball again and do it well.
Tight end: Kyle Pitts, Atlanta Falcons @ Jacksonville Jaguars
Pitts is the sixth-most targeted tight end this season (69) but has the third-most receiving yards (635), boosted massively by 100-yard games against the New York Jets and the Miami Dolphins either side of the Falcons' Week 6 bye.
The schedule slowed that momentum somewhat – Atlanta were held to three points across defeats to the Dallas Cowboys and the New England Patriots – but a trip to Jacksonville gives Pitts the opportunity to put his name up in lights once again.
The Jaguars have given up 7.20 yards per pass play in 2021, meaning this is unlikely to be the defense to keep Pitts in check. He has got open on 34.41 per cent of his 93 matchups, up on the tight end average of 18.10 per cent.
Defense: New England Patriots vs. Tennessee Titans
The Titans head into this week as the top seed in the AFC, but the Patriots may well take that spot from them over the next two weeks, hosting Tennessee before going to the Buffalo Bills in Monday Night Football.
While Mac Jones is enjoying a fine rookie year at QB, it will be New England's defense that puts them in contention, having given up only 5.07 yards per play while securing 21 total takeaways – ranking third in both regards.
And the Pats will expect to dominate the Titans, whose injury list has only grown since Derrick Henry went down. A.J. Brown is the latest offensive weapon to be unhealthy, while Julio Jones is not expected back for another two weeks.
These problems contributed to a woeful defeat to the Houston Texans last time out, when Ryan Tannehill threw four picks. Elsewhere in Week 10, New England caught four interceptions against the Falcons.
Milan 3-1 Hellas Verona: Leao double condemns visitors to Serie A relegation play-off
Milan signed off the Serie A season with a 3-1 victory as Rafael Leao's double condemned Hellas Verona to a relegation play-off with Spezia.
The Rossoneri wrapped up a frustrating campaign on a winning note at San Siro, with a late Leao brace enough to seal three points.
Milan had already secured Champions League football for another term but struggled at times against the visitors, who cancelled out Olivier Giroud's first-half penalty through Marco Faraoni's 72nd-minute strike.
Yet Leao struck in the 85th minute and again seven minutes later, leaving Verona to face a relegation decider with Spezia, who succumbed to a late 2-1 loss at Roma.
Udinese 0-1 Juventus: Chiesa strikes but Bianconeri miss out on top-six Serie A finish
Juventus missed the chance to finish sixth in Serie A despite Federico Chiesa's strike sealing a 1-0 victory over Udinese at Dacia Arena.
After Paulo Dybala's late penalty helped Roma to a 2-1 victory over Spezia, Massimiliano Allegri's side were unable to leapfrog the Giallorossi and were forced to settle for a seventh-place finish in the league.
Chiesa's second-half strike was the difference for Juve, who were deducted 10 points for violating financial rules earlier in a rollercoaster campaign, but they suffered their lowest finish in Serie A for 12 years.
Meanwhile, Udinese finished 12th in Serie A following their 10th defeat in 12 meetings with the Old Lady.
Udinese had lost their last three but went close after just four minutes when Beto somehow headed Florian Thauvin's cross over from inside the six-yard box.
Federico Chiesa’s deflected effort hit the side-netting before Juve saw a headed opportunity go begging as Leonardo Bonucci nodded against the crossbar from seven yards out following Arkadiusz Milik's flick-on.
Chiesa continued to cause Udinese problems down the left flank, yet the sides headed into half-time goalless after a profligate showing from both teams.
Juve squandered a great chance to break the deadlock just after the hour mark, Adrien Rabiot firing wide despite being found by Milik in acres of space inside the box.
But the visitors eventually opened the scoring in the 68th minute, Chiesa receiving the ball from Manuel Locatelli before bending a brilliant shot into the bottom-right corner.
Locatelli and Angel Di Maria went close to extending the advantage and though the single goal was enough, former Juve forward Dybala was to snatch sixth place for Roma from under his old club's nose.
Celta Vigo 2-1 Barcelona: Veiga double secures safety as Celestes stun champions
Gabri Veiga scored twice as Celta Vigo clinched survival with a surprise 2-1 win over champions Barcelona on a dramatic final day of the season in LaLiga.
Starting the game in 17th, Celta knew a victory would preserve their top-flight status, and Carlos Carvalhal's men took charge as Veiga struck either side of the break.
The 21-year-old drilled into the bottom-left corner to spark wild scenes at the Balaidos shortly before half-time, then saw a fortuitous 65th-minute cross sail in off the far post.
Celta clung on after Barca substitute Ansu Fati nodded home, clinching a 13th-placed finish as Real Valladolid went down, while Barca ended the campaign 10 points clear of runners-up Real Madrid.
Barca thought they had an 11th-minute lead when Franck Kessie latched onto a rebound to beat Ivan Villar, only for a VAR review to show the midfielder was offside.
Oscar Rodriguez skewed a first-time shot just wide as Celta went close, while Robert Lewandowski saw a curling effort clip the outside of Villar's left post.
The offside flag thwarted Rodriguez as he capitalised on Marc-Andre ter Stegen's error to flick home, but Celta did go ahead on the stroke of half-time when Veiga raced onto Haris Seferovic's pass to finish across goal.
With Barca struggling for momentum, Veiga put Celta 2-0 up when his mishit cross from the right swerved over substitute goalkeeper Inaki Pena, clipping the woodwork before nestling in the back of the net.
Fati ensured a nervous finish by heading in Ousmane Dembele's cross 11 minutes from time, but Celta clung on to ensure another season of top-flight football.
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