Early Eastern Conference leaders Philadelphia Union made a statement with a 2-0 win away to reigning MLS Cup champions New York City on Saturday.

Union scored first-half goals from Alejandro Bedoya and Daniel Gazdag, while Sergio Santos had a goal disallowed on the stroke of half-time, as Philadelphia got some revenge after last season's Eastern Conference final defeat to City.

Bedoya put Philadelphia ahead in the 12th minute, but City thought they had an avenue back into the game when referee Ted Unkel awarded them a penalty and sent off Jack Elliott for a 28th-minute last-man push on Santiago Rodriguez.

However, VAR intervened and determined that Rodriguez had illegally used his hand in the lead-up, meaning the penalty and red card were overturned.

The win was Philadephia's first at Yankee Stadium and came despite City bossing the possession count with 74 percent.

Former Liverpool and Bayern Munich attacker Xherdan Shaqiri netted his first MLS goal as Chicago Fire won 3-1 over Sporting KC.

Shaqiri scored from the spot in the 50th minute to make it 2-0 as Chicago extended its unbeaten start to the new season with Kacper Przybylko hitting a double.

Jesus Ferreira scored a first-half hat-trick as Dallas defeated Portland Timbers 4-1 in a sign of intent for the forward ahead of USA's upcoming World Cup qualifiers.

All three of Ferreira's goals came in a 10-minute span, marking his first-ever MLS hat-trick.

Gonzalo Higuain scored, but Inter Miami remain winless this term after a 3-1 loss away to last season's strugglers Cincinnati.

The result leaves Phil Neville's side with an MLS-worst record of one point from four games, having conceded 10 goals and only scored two.

Karol Swiderski netted a double as Charlotte upset New England Revolution 3-1, while Luis Amarilla's 32nd-minute strike lifted Western Conference leaders Minnesota United past San Jose Earthquakes 1-0.

Tyler Pasher's 90th minute goal salvaged a 1-1 home draw for Houston Dynamo against Colorado Rapids, while 10-man Atlanta United scored twice in the final five minutes to rescue a 3-3 draw with Montreal.

Facundo Torres' early goal got Orlando City past LA Galaxy 1-0, Bob Bradley's Toronto knocked off DC United 2-1 and Real Salt Lake edge 10-man Nashville 2-1.

Gonzalo Higuain is hopeful his former Argentina team-mate Lionel Messi will one day join him in Major League Soccer.

Higuain is preparing for his second full season in MLS with Inter Miami, having joined from Juventus in September 2020.

Although the striker's goalscoring exploits had regressed slightly towards the end of his time in Europe, Higuain was still regarded as a major coup for both Inter and MLS, where his older brother Federico has plied his trade since 2012.

MLS has previously been considered a competition where fading stars from Europe went to see out the remainder of their careers, with the likes of Thierry Henry, Andrea Pirlo, David Villa and Steven Gerrard all doing just that.

But the perception is changing slightly – it is becoming a proving ground for young talent, a viable stepping stone to Europe for South American players and even a place for established European stars who are still at the height of their powers.

Napoli forward Lorenzo Insigne highlighted the shift last month by agreeing an end-of-season move to Toronto despite being virtually in his prime. While any MLS switch for Messi, already 34, would look a little more like a final pre-retirement move, Higuain reckons he would enjoy himself.

"It is a very important league and it is growing a lot," Higuain told Stats Perform.

"Important players are coming and I think that in the future it will continue to grow much more.

"I hope [Messi goes to MLS] because it would be a benefit for MLS and for the country, and if he so wishes he would have fun and be happy here."

Inter begin their 2022 MLS campaign at home to Chicago Fire on Saturday, with the David Beckham-backed franchise hoping to enjoy a major improvement from last season.

Phil Neville's side finished 11th in the 14-team Eastern Conference in 2021, a place above Saturday's opponents, while their points total of 41 was better than only six teams across the two MLS divisions.

It would seem Inter may have struggled even more were it not for Higuain, who scored 12 times. His haul of nine non-penalty (np) goals matched up well with his np-xG (expected goals) of 8.7, suggesting the team could really profit from dependable finishing if the service to him improves.

And bettering that return in front of goal is high on Higuain's list of priorities.

"We are fine, looking forward to [the start of the season] and very excited," he said. "It's so close now, let's hope it goes better than last year and we learn from the mistakes made so that this year it doesn't happen again. We are excited to have a good year.

"I want to improve my numbers, which I did my whole career, improve year after year. I hope that this year I can do better to help the team qualify [for the playoffs] and be able to compete for MLS.

"I hope I can improve my numbers, that's my goal and that's what I've prepared this pre-season."

Lionel Messi is wanted by MLS side Inter Miami, according to former Argentina team-mate Gonzalo Higuain.

Messi completed a momentous free transfer to Paris Saint-Germain in August, with Barcelona being unable to afford a new deal for the Blaugrana great amid financial difficulties.

The Argentina captain enjoyed a cameo against Reims before making his full debut away at Club Brugge in the Champions League on Wednesday, hitting the crossbar in a 1-1 draw.

However, Miami forward Higuain hinted that the door is already open for Messi's potential next move – the second time he has done so after advocating a potential transfer in March.

"Don't get me into trouble… I have no idea about Leo [Lionel Messi] in Miami," Higuain told ESPN Argentina.

"I have one year left on my contract and Leo I think he signed 2 or 3 years in Paris, I don't think we agreed. The club wants it, let's see."

Higuain also made his standpoint on his future very clear and explained admiration for Miami's joint-owner David Beckham.

Having joined Beckham's franchise in September last year, the ex-Real Madrid, Napoli and Juventus striker has netted 10 times in 30 MLS outings, though he believes next season will be his last for the time being.

"Honestly, you are very far from the competition in Europe, it is a league that takes a lot of affection but now that there are people the truth is that I am enjoying it a lot," Higuain added.

"There are many players who want to come and play here. The league is very nice, I like to play it. Good teams, good players.

"After that year [left on his contract] I take a sabbatical, away from football and everything."

Gonzalo Higuain scored the winner as resurgent Inter Miami continued their excellent run of form with a fifth straight home win beating Columbus Crew 1-0 in the MLS on Saturday.

Higuain struck the winner in the 16th minute for Inter who have claimed 13 points from their past five matches to surge up to ninth in the Eastern Conference.

Inter had endured a six-game losing span in May and June but Phil Neville's side have bounced back, losing only once in their past 10.

The former Real Madrid forward swooped on a wayward back pass from Josh Williams, taking a touch inside the box and dinking a shot over Crew keeper Eloy Room, with Vito Wormgoor unable to clear it on the line.

New England maintained their stronghold on the lead at the top of the table with a come-from-behind 2-1 win over 10-man New York City.

Santiago Rodriguez had put City ahead with an 11th-minute volley before Revolution midfielder Emmanuel Boateng drive in a low leveller 10 minutes later. Tom McNamara may have put New England ahead when he hit the post late in the half.

Alfredo Morales was sent off for a second bookable offence, an heavy tackle on McNamara, early in the second half.

New England capitalized with in-form Tajon Buchanan coming up with a 65th minute winner from Carles Gil's assist.

Nashville maintained their strong season with a 1-0 victory on the road over Montreal after Walker Zimmerman's glancing 66th-minute header, keeping them second in the Eastern Conference behind New England.

Sporting KC struck twice inside the first 10 minutes from Jose Mauri and Johnny Russell as they won 2-0 over Chicago Fire to stay in touch with Western Conference leaders Seattle Sounders.

Colorado Rapids squandered an opportunity to temporarily go top in the west after Samuel Grandsir's late equalizer for LA Galaxy in a 1-1 draw. The Rapids instead slip to third below KC.

Seattle Sounders remained first in the west with a 1-0 home win over Minnesota United thanks to Joao Paulo's 22nd-minute strike.

Teenage sensation Ricardo Pepi scored his 12th goal of the season as Dallas drew 1-1 with San Jose Earthquakes, while lowly Houston Dynamo won 3-0 over fellow Texas outfit Austin.

New York Red Bulls continue to struggle for wins, only managing a 1-1 home draw with DC United after a controversial penalty award for a Sean Nealis handball.

Cincinnati snapped their three-game losing run with a 2-0 home win over struggling Toronto, who have lost five in a row.

Gonzalo Higuain netted the equalizer as Inter Miami continued their recent upturn in form with a 2-1 home win over Nashville in the MLS on Sunday.

Phil Neville's Inter have now claimed eight points from their past four games, having been rooted to the bottom of the Eastern Conference after six defeats in a row.

Nashville had taken the lead early in the second half from Charles Sapong but Miami responded on the hour mark.

Ex-France international Blaise Matuidi played in former Real Madrid forward Higuain who calmly collected the ball and slotted home for 1-1.

Inter dramatically claimed all three points in the 95th minute when Gonzalo's brother Federico Higuain whipped in a well-weighted cross for Indiana Vassilev to head home.

The win moves Miami out of last spot in the east and up to 12th.

At the other end of the conference table, New England Revolution moved 10 points clear with a 2-1 home win over Philadelphia Union.

Matthew Polster and Gustavo Bou netted first-half goals, sandwiching Paxten Aaronson's strike to extend New England's unbeaten run to six games.

Bou's goal came after his 39th-minute penalty was saved by Union goalkeeper Andre Blake, only for the Argentine to convert the rebound.

New York Red Bulls are winless in six after going down 2-1 to lowly Chicago Fire following Serbian midfielder Luka Stojanovic's early double strike.

DC United came from behind to win 2-1 over Montreal, while San Jose Earthquakes beat LAFC 2-1 in the Western Conference.

LA Galaxy were held to a 1-1 home draw by Vancouver Whitecaps with Kevin Cabral's 32nd-minute goal cancelled out by Ranko Veselinovic's 50th-minute reply.

San Jose Earthquakes snapped a pair of skids in stunning fashion on Saturday with a 1-0 road defeat of Seattle Sounders.

The victory was San Jose's first since May 7, ending an 11-match winless streak, and their first win over Seattle since September 2015, halting a 14-game drought.

Cristian Espinoza's goal in first-half stoppage time, a left-footed strike from just outside the 18-yard box, made the difference for San Jose.

San Jose thought they had another in the 89th minute but Chris Wondolowski's goal was disallowed after a video review.

New England Revolution extended their lead atop the Eastern Conference with some late magic in a 3-2 win away to New York Red Bulls.

Brandon Bye netted in the 84th minute to equalise for New England and Adam Buksa's goal in stoppage time gave the Revs their fourth straight win, leaving them eight points clear of second-placed Orlando City.

Sporting Kansas City lost a chance to move past Seattle for the top spot in the Western Conference, suffering a 2-1 defeat to Dallas as Paxton Pomykal and Jesus Ferreira netted for the visitors.

Gonzalo Higuain's second-half brace sent Inter Miami past Montreal 2-1 to end a seven-game winless streak for head coach Phil Neville's side.

DC United held on to earn a point in a 0-0 draw with Cincinnati despite having Moses Nyeman sent off in the 52nd minute and Joseph Mora in the 90th to finish with nine men.

Real Salt Lake also managed a 0-0 draw with Houston even after Justen Glad's 87th-minute red card.

Andre Shinyashiki's 29th-minute goal gave Colorado a 1-0 road win over Austin.

Cristian Dajome drew and converted a penalty four minutes into second-half stoppage time to give Vancouver a 2-2 draw with Minnesota United. Dajome had opened the scoring in the 36th minute before Ethan Finlay equalised in the 45th and Robin Lod gave Minnesota the lead after 75 minutes.

Nani scored a stunning late goal to lead high-flying Orlando City to a 2-1 win at MLS rivals Inter Miami.

Orlando rallied away to David Beckham's Inter Miami on Friday, Nani's memorable 80th-minute effort completing the comeback.

After a scoreless opening half, former Juventus and Real Madrid forward Gonzalo Higuain had come off the bench to give Inter Miami a 67th-minute lead.

Higuain scored within seven minutes of his introduction, a low shot from distance putting the hosts ahead at DRV PNK Stadium in Fort Lauderdale.

But Orlando hit back within six minutes – Chris Mueller teed up by Nani for the equaliser before the latter decided the contest.

Former Manchester United star Nani cut onto his right foot and hit a powerful strike from the edge of the penalty area with 10 minutes remaining.

After three wins in six days, Orlando are now second in the Eastern Conference and just two points behind New England Revolution, while Inter Miami are 11th.

Seattle Sounders preserved their unbeaten record after seeing off Los Angeles FC 2-0 in MLS action on Sunday, while Gonzalo Higuain's double inspired Inter Miami.

The Sounders remain undefeated through six matches this season thanks to a two-goal second half at Lumen Field in Seattle.

Entering the contest, Seattle had 13 points from their first five matches for the second time in the last three seasons – the only team in the last 20 seasons to have at least 13 points after five games more than once.

The Sounders stayed hot courtesy of Xavier Arreaga and Brad Smith – the former opening the scoring in the 57th minute.

Smith doubled the lead with 17 minutes remaining when the Australian full-back pounced for his third goal of the season.

The Sounders are four points clear of LA Galaxy in the Western Conference, while Sporting Kansas City are a point further back in third following their 3-0 win over Vancouver Whitecaps.

LAFC are bottom of the west with five points from five matches in 2021.

Former Juventus and Real Madrid forward Higuain was the hero for Inter Miami, who prevailed 3-2 in a thriller at Cincinnati.

Higuain scored the winning goal five minutes from the end after Cincinnati's Nick Hagglund has restored parity three minutes earlier.

David Beckham's Inter Miami – led by former Manchester United team-mate and head coach Phil Neville – raced out to a 2-0 half-time lead via Brek Shea and Higuain before Cincinnati rallied with goals from Alvaro Barreal and Hagglund.

Former Argentina international Higuain, though, had the final say with his fourth goal of the season.

Elsewhere, New England Revolution topped defending champions Columbus Crew 1-0 and Orlando City beat DC United by the same scoreline.

Orlando have opened the season unbeaten in their first five games (W2 D3). The Lions have lost just three regular-season matches since the end of the MLS is Back Tournament, fewer than any other team that was in MLS both last season and this.

Raul Ruidiaz scored a brace as Seattle Sounders continued their strong start to the MLS season with a 3-0 home win over previously unbeaten LA Galaxy on Sunday.

Australian full-back Brad Smith provided an assist for Ruidiaz's 20th-minute opener, before scoring a goal himself three minutes later, forcing home a rebound.

Ruidiaz settled the contest in second-half stoppage time when he fired home on his left foot from substitute Jimmy Medranda's low cross.

The Sounders dulled the threat of Galaxy forward Javier 'Chicharito' Hernandez – who had scored five goals in his opening two games – in a strong display, where they marginally lost possession but had nine to two shots on target.

The win moves Seattle to seven points from three games to start the new campaign, while the Galaxy suffered their first blemish of the campaign after scoring six goals in their opening two games.

Inter Miami drew a blank in the absence of the Higuain brothers with a 0-0 draw away to Nashville.

Former Juventus and Real Madrid forward Gonzalo Higuain and brother Federico were unavailable for the match after flying back to their native Argentina following the death of their mother to cancer.

The Higuain brothers' team-mates offered a wonderful sign of support ahead of the game.

Inter Miami – co-owned by former Manchester United, Madrid and England star David Beckham – have four points from three games, while Nashville are still winless but have drawn all three matches this season.

Diego Rubio's incredible free-kick helped Colorado Rapids to a 1-0 victory away to Vancouver Whitecaps.

Rubio struck in the 26th minute with a curling right-foot shot that found the top corner, going in off the post and crossbar.

The spectacular strike earned the Rapids their first three points of the season, while condemning the Whitecaps to their first defeat.

Gonzalo Higuain made it two goals in two games as Inter Miami came from behind to 2-1 win away to Philadelphia Union in Saturday's Major League Soccer.

Former Juventus and Real Madrid forward Higuain along with brother Federico made history as the first time two brothers scored in the same game.

Last season's Supporters' Shield winners Philadelphia had taken a 54th minute lead through Jamiro Monteiro.

But Federico Higuain came off the bench 10 minutes later to devastating effect, getting the assist for Gonzalo's 73rd minute leveler from a set-piece.

Federico proceeded to head home the winner on 83 minutes and lift Inter Miami to their first win of the 2021 season, while Philadelphia are winless after two games.

Barco launches Atlanta rocket

Ezequiel Barco netted a spectacular goal as Atlanta United made a statement with a 3-1 home win over the Chicago Fire.

Barco's initial free-kick set-piece cannoned into the wall but he fired home the rebound emphatically to give his side the lead.

Chicago leveled through Serbian midfielder Luka Stojanovic straight after the break, but Atlanta re-claimed the lead after a 66th minute Johan Kappelhof own goal and Emerson Hyndman's 85th minute strike.

Last season's beaten MLS Cup finalists Seattle Sounders managed a tie away to LAFC with Australian full-back Brad Smith scoring a 54th minute equaliser.

Colombian midfielder Eduard Atuesta had given the hosts a second minute lead.

Christhian Paredes went from zero to hero after scoring an own goal before netting the winner as the Portland Timbers edged Houston Dynamo 2-1.

Paredes' 73rd minute winner came from a superb long ball by Bill Tuiloma which was headed into the Paraguayan's path by Felipe Mora.

Ochoa sparks fracas

Real Salt Lake goalkeeper David Ochoa, 20, sparked a post-match fracas after punting the ball into the Minnesota United home fans area, the Wonderwall, upon the final whistle after his side's 2-1 away win. He drew the ire of United coach Adrian Heath who said: "It's a no-no. He's got some edge on him for a kid who's not that good."

History-making Austin victory

Austin FC made history with their first-ever franchise goal in the MLS and their maiden MLS win, coming from behind to triumph 3-1 away to the Colorado Rapids.

Saturday's results:

New York City 5-0 FC Cincinnati
Nashville SC 2-2 CF Montreal
Toronto FC 2-2 Vancouver Whitecaps
San Jose Earthquakes 3-1 FC Dallas
Los Angeles FC 1-1 Seattle Sounders
New England Revolution 1-0 D.C. United
Real Salt Lake 2-1 Minnesota United 
Atlanta United 3-1 Chicago Fire
Inter Miami 2-1 Philadelphia Union
Austin FC 3-1 Colorado Rapids
Portland Timbers 2-1 Houston Dynamo

Red Bulls at LA

The Los Angeles Galaxy host the New York Red Bulls, who lost on the opening weekend, in Sunday's only match.

Javier 'Chicharito' Hernandez started the MLS season with a bang, scoring twice as LA Galaxy spoiled Phil Neville's Inter Miami debut in a 3-2 victory.

Former Manchester United and Real Madrid striker Chicharito endured a difficult and injury-plagued 2020 season, Mexico's all-time leading goalscorer netting just twice after joining the Galaxy.

But Chicharito kicked off his redemption season in style – his two-goal second half sinking David Beckham's Inter Miami in Sunday's season opener.

"I'm holding [back] my tears. I suffered the loss of my grandfather, I would love him to keep watching [me] scoring goals," Chicharito said. "I'm very touched because, like I told you, last year was very difficult.

"I miss him so much and these goals are for him, my kids, my whole family, my friends, everyone. I maintain patience, I keep grinding and thankfully things are coming around and hopefully, like I say, I just want to be a part of an unbelievable season and lift the trophy."

Trailing to Robbie Robinson's opening goal in first-half stoppage time, Chicharito equalised just past the hour mark in front of a sell-out crowd in Miami.

Former Juventus and Real Madrid striker Gonzalo Higuain restored Inter Miami's lead in the 68th minute – just his second goal for the club since arriving in the United States.

It had ex-United utility and former England women's boss Neville dreaming of a dream start in Miami, where he replaced Diego Alonso as head coach ahead of the 2021 season.

But Chicharito levelled proceedings again with a trademark header 17 minutes from the end before Sacha Kljestan put the Galaxy in front in the 81st minute.

Elsewhere, reigning champions Columbus Crew drew 0-0 against Supporters' Shield holders Philadelphia Union, while Vancouver Whitecaps edged Portland Timbers 1-0.