San Francisco 49ers starting quarterback Jimmy Garoppolo was carted off the field and ruled out of Sunday's game against the Miami Dolphins after only eight plays.

Garoppolo was sacked by Dolphins duo Jaelan Phillips and Jerome Baker on the 49ers' first drive, staying down and eventually needing the cart to carry him back down the tunnel.

He was swiftly ruled out of the remainder of the contest due to the foot injury he sustained, with rookie Brock Purdy brought in as the 49ers' new signal-caller. Purdy was the very last pick in this year's NFL Draft, earning him the title of 'Mr Irrelevant'.

Nevertheless, Purdy closed the first half in style, delivering short-range touchdown passes to Christian McCaffrey and Kyle Juszczyk to head into the break with the 49ers leading 17-10.

At 7-4 while boasting arguably the best defense in the NFL, the 49ers' Super Bowl dreams will take a massive hit if Garoppolo's injury keeps him on the sideline for an extended period.

With just six weeks left of the regular season schedule, the drama in the NFL continues to ramp up.

The playoff picture is wide open and Week 13 action presents clashes between a number of sides who each boast a winning record this season.

Victories this week would provide a considerable boost for those teams' hopes of continuing beyond the regular campaign.

A huge divisional rivalry between the Washington Commanders and New York Giants is the pick of the action, while there is also a rematch from last season's AFC Championship game with the Kansas City Chiefs seeking redemption against the Cincinnati Bengals.

Stats Perform has delved into the numbers for those matchups along with some of Sunday's other big games.

New York Jets (7-4) @ Minnesota Vikings (9-2)

The Jets head to Minnesota with an 8-3 record against the Vikings, though have lost the last two meetings – including a 37-17 loss in the last meeting in 2018, which marked the most ever points scored by the Vikings in this series.

Defensive strength has been key for the Jets this season, with last week's 31-10 victory over the Chicago Bears being the fourth time this year where they have held their opponents to 10 or fewer points – the last time they had such a sequence was five games in 2010, which was also their last season with a trip to the playoffs.

The Jets defense will be tested against the Vikings' aerial threat, however, with Justin Jefferson and Adam Thielen each catching touchdown passes in the Thanksgiving win over the New England Patriots – the ninth time each player has had a receiving TD in the same game, which marks the most of any NFL teammates since Jefferson's 2020 debut.

A win against the Jets would see head coach Kevin O'Connell join Jim Caldwell and Jim Harbaugh as the only men this century to earn 10 wins in 12 or fewer games to start their career as an NFL head coach.

Washington Commanders (7-5) @ New York Giants (7-4)

A series sweep for Washington last season was the franchise's first against the Giants since 2011, leaving the Commanders looking for their first win streak of at least three games against New York since a four-game streak that ended in 2000.

Four consecutive wins on the road have seen Washington hold their opponents to 54 points total in those contests, marking the first time they have won four straight road games while allowing fewer than 60 points since 2001.

The Giants head into the contest having lost their last five against divisional opponents, standing just 1-7 in that regard over the past two seasons. That makes them just one of two teams without multiple wins in divisional games over that span (also Denver Broncos, 1-8).

Saquon Barkley remains the biggest threat for the Giants and sits just eight rushing yards short of his third 1000-yard season, where he would join Tiki Barber (6), Rodney Hampton (5) and Joe Morris (3) as the only Giants with at least three such seasons for the team.

Tennessee Titans (7-4) @ Philadelphia Eagles (10-1)

Philadelphia host the Titans on the back of a six-game winning run against AFC opponents dating back to last season, matching the Eagles' longest such streak in franchise history.

Last time out against the Green Bay Packers, the Eagles scored a touchdown in four of their five trips to the red zone – with Philadelphia leading the NFL in touchdown efficiency in the red zone this season, scoring in 29 of 40 trips (72.5 per cent).

Tennessee, meanwhile, have rushed for fewer than 100 yards in each of their last three games, matching their longest streak since Mike Vrabel became head coach in 2018.

In the 20-16 loss to the Bengals last time out, Derrick Henry fumbled but was it was recovered. Of the 39 players with at least 200 offensive touches since the beginning of last season, Henry, Leonard Fournette and Christian McCaffrey are the only three to have not lost a fumble.

Kansas City Chiefs (9-2) @ Cincinnati Bengals (7-4)

Two meetings last season saw the Bengals win by three points in both contests, including in the AFC Championship game in Kansas City, with the Chiefs' last road win against the Bengals coming in 1984 – losing six straight since.

A 26-10 home victory against the Los Angeles Rams last week saw Travis Kelce catch his 12th touchdown pass of the season, with no other tight end having more than five this term. The largest all-time gap between a league leader and second place stands at six (Rob Gronkowski in 2011 and Antonio Gates in 2004).

The Bengals overcame the Titans 20-16 on the road last week, giving Cincinnati their first three-game winning streak of the season. Since 2018, they stand 3-34 when scoring 20 or fewer points in a game, but two of those wins have come against Tennessee.

Cincinnati have converted 78.1 per cent (25-for-32) of their third downs this season when needing fewer than four yards, the best mark in the league. However, they've also allowed opponents to convert such third downs at a 76.5 per cent rate (26-for-34), the worst record in the league.

Elsewhere…

The Miami Dolphins head to San Francisco with a 4-3 record on the road against the 49ers, the second-best such record by any team behind the Carolina Panthers (7-4).

The Los Angeles Rams host the Seattle Seahawks having won eight of the last 10 clashes between the two divisional rivals, with Seattle's last victory on the road in this matchup coming in Week 5, 2017.

An overtime victory over the Seahawks last week was the second in a row for the Las Vegas Raiders, having beaten the Denver Broncos in OT in Week 11. No NFL team has ever won three consecutive games in overtime going into the Raiders' latest battle with the Los Angeles Chargers.

The Dallas Cowboys host the Indianapolis Colts on the back of a four-game spell with at least 400 net yards, with only one longer streak in team history – running eight games in that regard in 2016.

No journey to the Super Bowl is ever linear. Ever since the Miami Dolphins achieved football perfection in 1972, every team that has climbed the mountain has had to experience some kind of bump in the road, and any team that harbours ambitions of adding their name to the list must show an ability to win in different ways and prevail when one side of the ball misfires.

The 2022 San Francisco 49ers have hit several bumps in the road. From a Week 1 loss to the Chicago Bears in a monsoon, to losing the anointed quarterback of the future, Trey Lance, to a season-ending ankle injury in Week 2 and suffering back-to-back losses to the Atlanta Falcons and the Kansas City Chiefs, the latter of which saw them ship 44 points, there have been plenty of points this season where belief in the 49ers as the Super Bowl contenders has been tested.

But San Francisco's response to the blowout Week 7 loss to the Chiefs has been emphatic and has reaffirmed the 49ers' status as a heavyweight in the NFC.

The 49ers have reeled off four successive victories to surge to 7-4 and, if the season ended today, would win the NFC West and enter the playoffs as an extremely dangerous third seed.

Two of those four wins have been blowouts, San Francisco marrying devastating offense from a group overflowing with playmakers following the October trade for Christian McCaffrey with tremendous defensive fortitude to destroy a pair of NFC West rivals in the Los Angeles Rams and Arizona Cardinals on the road.

Even with the level of star talent they have at their disposal, the 49ers' offense has not been consistent. A continuing theme of their recent dominance has been DeMeco Ryans' defense, which reached its 2022 zenith to this point on Sunday with a shutout 13-0 win over the New Orleans Saints.

It was a performance that served as an encapsulation of why Ryans is likely to be the premier head coaching candidate this offseason and one that should serve to raise the question of whether his defense is one that could be among the select few that carries its team to Super Bowl glory.

The numbers point heavily to the 49er defense being of that standard.

San Francisco's shutout was the Niners' first since they beat Washington 9-0 in the 2019 season, and it was the first suffered by the Saints since Week 17 of the 2001 season. The 49ers were the team to dole out the shutout on that occasion in a 38-0 win.

While it was a 20-year low point for the Saints on offense, for the 49ers it was a continuation of an eye-opening run of defensive obduracy. The Niners have now pitched four consecutive shutouts in the second half, also keeping the Rams, Los Angeles Chargers and Cardinals off the board in the final two quarters. Achieving the feat for four quarters against the Saints, they have now not conceded a point in over 94 minutes of game action.

The 49ers' refusal to let the Saints avoid drawing a blank was made more amazing by the fact New Orleans had six plays from inside San Francisco's five-yard line, and the season-long defensive numbers for the Niners paint the picture of the defiance shown by Ryans' group that could well come to define their season.

San Francisco's defense ranks first in points per game allowed, yards per game allowed, rush yards per game allowed, yards per rush allowed, first downs per game allowed and passing touchdowns allowed.

Simply put, this is a defense that can shut down anything an opposing offense does well, and it has multiple means by which it can do so.

The 49ers have the sixth-highest sack rate in the NFL at 7.9 per cent but have a blitz rate of 28.7 per cent that is below the league average of 30.8 per cent, those numbers speaking to San Francisco's long-established ability to get home by only sending four pass rushers from their exceptionally deep defensive line.

Nick Bosa, the star of that front, recorded the fourth-down sack that essentially ensured the Saints would not score in Week 12, taking his tally for the year to 11.5.

Bosa is the fifth player since 2000 to record at least one sack in nine of his first 10 games of a season, joining Hugh Douglas (2000), Everson Griffen (2017), Robert Mathis (2005) and Demarcus Ware (2008).

Yet the Niners have also made a habit of sending successful blitzes at the right time, with linebacker Fred Warner and safety Talanoa Hufanga – who each forced fumbles on Sunday – proving adept at generating pressure when rushing from the second level of the defense.

Hufanga's physicality jarred a fumble from Alvin Kamara at the one-yard line in the first of two fourth-quarter red zone stops against New Orleans, the former fifth-round pick emerging as a star in a secondary that has duplicity to frustrate teams with precise and disciplined zone coverage and facilitate blitzes by succeeding when it pivots to man coverage, with cornerback Charvarius Ward, the 49ers' headline free agency acquisition, excelling in both areas.

As with many defenses around the NFL, the 49ers rely heavily on two-high safety zone coverages; however, they have used Cover 1 man on 13.35 per cent of defensive snaps, well above the league average of 10.64 per cent. When using that coverage, they have given up 5.22 yards per play, over a yard fewer than the league average of 6.58.

In essence, the personnel Ryans has at his disposal allows him to easily switch between the staple of a four-man rush with zone coverage behind it and a more aggressive approach at any point and still have complete confidence his defense will deliver.

Though blitzes are not an overly common feature of the game plan, San Francisco's underpinning defensive philosophy is all about aggression, which is evident throughout when Ryans' players are on the field, their relentless pursuit of the football critical to the 49ers' incredible success against the run – opponents have gained only 3.1 yards per play on the ground versus San Francisco – and game-sealing turnovers such as Kamara's goal-line fumble.

That defensive violence ensured San Francisco did not follow the 49ers' offensive fireshow against the Cardinals in Mexico City with a letdown even as that attack sputtered in comparison to its efforts at Estadio Azteca.

Fast, physical, disciplined and diverse with the players at every level to consistently dominate, the 2022 49ers defense has all the ingredients of a championship unit and proved it can carry the load in ensuring San Francisco won in a very different way in Week 12 following the blowout of Week 11.

With Jimmy Garoppolo playing some of the best football of his career, after sticking around to back up Lance in a prescient move by both player and franchise, and blessed with a skill-position group that features McCaffrey, Deebo Samuel, Brandon Aiyuk and George Kittle, the hope will be the defense will not have to shoulder the burden on a regular basis. But this four-game stretch has proven unequivocally that it can do so, and that is an excellent insurance policy for the 49ers as they plot a path to a second Super Bowl appearance in four seasons.

San Francisco 49ers running back Elijah Mitchell will spend at least the next six weeks on the sidelines after suffering his second MCL sprain of the season in Sunday's win against the New Orleans Saints.

It is the same injury he suffered in Week 1, and in that instance he did not return until Week 10, proceeding to contribute in three consecutive wins before bad luck struck again.

A sixth-round pick in last year's NFL Draft, Mitchell burst onto the scene with 1,100 yards from scrimmage as a rookie, but following his injury to begin this season, the 49ers made the decision to invest further in the running back position.

Their trade for former Carolina Panthers superstar Christian McCaffrey insulates the 49ers from the crushing blow of this injury, as it will result in an increased workload for the two-time All-Pro.

Niners head coach Kyle Shanahan said he felt for the 24-year-old after the news of his impending stint on the sidelines.

"It wasn't the news we were looking for," he told reporters. "He's pretty disappointed. 

"Everyone knows how good Elijah has been, how hard he worked to get back from his last one, how good he's been playing since he came back, and to kind of be right back there, I know he was real down on it. 

"It's unfortunate for him. He's just had some real bad luck."

He added: "He knows what's ahead of him. He's just going to have about six weeks of frustration, but hopefully we can do our job here so when he comes back, we're still playing."

There are six weeks remaining in the regular season, and with a 7-4 record, the 49ers are a strong contender for a deep playoff run.

This Thursday marks Thanksgiving in the United States.

That means several things. Food, family and lots and lots of football, with the traditional three games on the schedule for the holiday.

With the Buffalo Bills, Dallas Cowboys and Minnesota Vikings all playing, there will be plenty of fantasy relevant players in action, meaning there's no time to waste in terms of getting a winning line-up set.

Thanksgiving is, as the name makes obvious, a time to say what you're grateful for, and Stats Perform hopes you will be appreciative of the fantasy help we're here to provide with our picks of four offensive players and a defense for Week 12.
 

Quarterback: Justin Herbert, Los Angeles Chargers @ Arizona Cardinals

The Chargers may not be feeling too grateful after having their heart broken again by Patrick Mahomes and the Kansas City Chiefs on Sunday.

But they must be appreciative of getting to face the Cardinals' defense in Week 12, especially with Herbert's top receiver, Keenan Allen, back in the fold.

The Cardinals have allowed 118 pass plays of 10 yards or more, the fourth-most in the NFL. Coming off a game in which he averaged 9.3 yards per attempt, Herbert is well-positioned to get the Chargers' playoff push back on track against opposition that should facilitate one of his best performances of the season.

Running Back: Jeff Wilson Jr, Miami Dolphins vs. Houston Texans

When Dolphins head coach Mike McDaniel sits down to eat his turkey on Thursday, he may express thanks for the trade with his former employers, the San Francisco 49ers, that landed Wilson's services for Miami.

Wilson has quickly established himself as the top runner in a Dolphins backfield that was not firing on all cylinders prior to his arrival.

He averaged seven yards per carry against the Cleveland Browns' dreadful run defense last time out and now gets to face a Houston defense that has allowed 57 runs of at least 10 yards, which is 12 more than anyone else in the league.

Wide Receiver: Amon-Ra St. Brown, Detroit Lions vs. Buffalo Bills

Detroit's leading receiver may not be happy to go against the Buffalo defense in Week 12, but Jameson Williams' debut is likely to bring a smile to his face.

Williams, Detroit's second first-round pick in 2022, is practising after recovering from a torn ACL he suffered in his final college game, and will give the Lions a tremendous deep threat who can stretch the field and open underneath areas for St. Brown to exploit.

In a game where the chances of the Lions falling behind and being forced to throw the ball consistently are high, that is a recipe for St. Brown racking up completions and yardage in the Thanksgiving opener.

Tight End: T.J. Hockenson, Minnesota Vikings vs. New England Patriots

There is likely to be gratitude in Vikings circles that they get the chance to quickly wash the stink off from their blowout loss to the Dallas Cowboys in Week 11.

Having been shellacked by the Cowboy defense, the Minnesota offense will face a different challenge in the form of the Patriots, who consistently drop eight players into coverage.

New England will almost certainly look to take Justin Jefferson away with double teams, meaning quarterback Kirk Cousins will likely have to frequently look to Hockenson over the middle of the field.

Targeted 28 times in three games since his arrival in a trade with Detroit, Hockenson appears primed for massive fantasy performance in the Thanksgiving nightcap, especially in points per reception leagues.

Defense/Special Teams: San Francisco 49ers vs. New Orleans Saints

The Saints' coaching staff may have a stressful Thanksgiving game planning for the 49ers, who appear to be rounding into form on both sides of the ball.

San Francisco's defense has not allowed a second-half point in any of the Niners' last three games and is giving up just 4.67 yards per play this season, the second-fewest in the NFL.

Facing a Saints offense that has committed the most giveaways (19) in the NFL, the San Francisco defense should dominate once more and deliver a crucial contribution for its fantasy owners.

San Francisco 49ers cornerback Charvarius Ward did not gain any respect for star Arizona Cardinals receiver DeAndre Hopkins when they matched up on Monday.

The 49ers won the contest convincingly 38-10 as the Cardinals were without starting quarterback Kyler Murray, missing his second consecutive game through injury.

Despite the Cardinals' struggles, Hopkins managed a productive outing, catching nine passes for 91 yards from his 12 targets. Since his return from a six-week suspension for traces of performance enhancing drugs in his system, Hopkins leads the NFL in both targets and catches.

However, speaking to the 49ers' radio broadcast after the win, Ward took the opportunity to trash the five-time All-Pro, calling him "steroid boy".

"D-Hop, he think he a tough guy," he said. "He think he still one of the best receivers in the league, and he really not.

"He was getting locked up. He was doing some dirty things. He tried to clip me, he grabbed me by the throat. He grabbed my facemask on one play, so I don’t respect his game. That’s steroid boy."

Ward, who arrived as a key free agent signing in the offseason from the Kansas City Chiefs, led the 49ers in total tackles in the game, tying his season-high with 10.

It was the third consecutive week the 49ers' defense have not allowed a single point in the second half, leading to three wins on the trot to climb atop the NFC West with a 6-4 record.

San Francisco 49ers quarterback Jimmy Garoppolo was full of praise for his teammates after he threw a season-high four touchdown passes in a strong 38-10 win against the Arizona Cardinals on Monday in Mexico City.

Garoppolo had not thrown more than two touchdowns in a game since October 2020, but gave two scores to tight end George Kittle and two to wide receiver Brandon Aiyuk to run up the score.

It was also the third consecutive game the 49ers' defense have not allowed a single point in the second half, with the Cardinals' last score coming with five minutes to go in the second quarter as they struggled to move the ball without starting quarterback Kyler Murray.

Speaking to ESPN on the field immediately after the final whistle, Garoppolo made sure to spread the credit around for the offense's success.

"It was just guys making plays today," he said. "All the receivers stepped up, the offensive line played great, it was a clean pocket all night. 

"When it's like that, it makes for a fun night. It was an electric atmosphere, so we were feeding off that.

"We've got some playmakers, and we get the ball in their hands. You see George [Kittle] at the end there, [Aiyuk] breaking some tackles and scoring – it made for a good night."

The 49ers led 14-10 at half-time, before winning the second half 24-0. When asked what impressed him about his side's defense after the break, Garoppolo said he can sense when they're switched on.

"Everything [impressed me]," he said. "I don't get to enjoy all of it, but you can feel from the sideline that they're hitting, they're making plays and having fun out there. That's what it's all about."

Star linebacker Fred Warner was also asked about San Francisco's suffocating defense, and he said he felt they could have been even better.

"It's crazy, because I think back at all the plays we could've made," he said. "But I look at that 10 on the scoreboard and I can't be too mad about it."

Their third consecutive win leaves the 49ers atop the NFC West, owning the tiebreaker against the division's other 6-4 team, the Seattle Seahawks.

The San Francisco 49ers did not allow the Arizona Cardinals to score a single point in the second half of Monday's 38-10 blowout in Mexico City.

Despite the lop-sided final result, the Cardinals scored the first points of the game with an early field goal, and after two short-range touchdown passes from the 49ers' Jimmy Garoppolo to Brandon Aiyuk and George Kittle, Arizona pulled it back to 14-10 with a James Conner goal-line touchdown run.

Unfortunately for the Cardinals, that touchdown in the second quarter would be their last points of the game, with the 49ers' defense figuring things out at halftime and producing a shut-out the rest of the way.

San Francisco put the game to bed with two more touchdowns in the third period – a second to Aiyuk, and a 39-yard end-around score for receiver Deebo Samuel – before adding the finishing touches with a second touchdown for Kittle in the last.

Having not thrown more than two touchdown passes in any game since October 2020, Garoppolo finished off completing 20 of his 29 passes for 228 yards and four scores, tying a career-high as his offense committed no turnovers.

Kittle caught four passes for 84 yards and two scores, doubling his touchdown tally for the season, while Aiyuk's two touchdowns came from his only two catches, giving him a six overall to lead the 49ers' pass-catchers this campaign.

At 6-4, the 49ers sit atop the NFC West, owning the tiebreaker with fellow 6-4 side the Seattle Seahawks, while the Cardinals fell to 4-7.

The NFL season has reached the point where the playoff picture truly starts to take shape.

Many players have proven themselves in an unpredictable 2022 campaign while others have fallen below expectations.

Stats Perform has focused on the former, selecting a pick for every position in Week 11, including the defense/special teams slot, for players that deserve to be in your consideration.

If you have any of these rostered, or they are somehow available on the waiver wire, now is the time to make your move!

Quarterback – Josh Allen, Buffalo Bills vs Cleveland Browns

Questionable for the entire week leading up to Week 10 against the Minnesota Vikings, Allen was not at his best as he threw two interceptions and had a critical late fumble in the fourth quarter, but still racked up the points.

A tally of 29 completions was Allen's highest since Week 2 against the Tennessee Titans (42), with a total of 330 yards his third-highest of the season. Cause for concern, however, is the fact Allen has thrown more interceptions (six) than touchdowns (three) over the past three weeks.

The Browns' defense has struggled to defend the pass, though, conceding 11.91 yards per completion on average, the sixth-worst in the NFL. Look for Allen to bounce back here.

Running back – Saquon Barkley, New York Giants vs Detroit Lions

No player has more rushing yards in the NFL this season than Barkley (931), who had 152 against the Houston Texans in Week 10, his highest return since 164 yards in Week 1 against the Titans.

With rushing touchdowns in seven of his nine games this season, including four in his last five, Barkley is almost guaranteed to yield a strong return of fantasy points – especially against a vulnerable Lions defense.

Only the Texans (1,636) have allowed more rushing yards this season than the Lions (1,448), while an average of 5.34 yards allowed per carry is third worst in the league – both numbers that will encourage Barkley to run riot.

Wide receiver – CeeDee Lamb, Dallas Cowboys @ Minnesota Vikings

The Cowboys' trip to Minnesota is a matchup where elite receivers will be the focus, with Justin Jefferson of the Vikings and the Cowboys' CeeDee Lamb top of the agenda – the latter being our pick for the week.

In the Week 10 loss to the Green Bay Packers, Lamb caught 11 of 15 targets and racked up 150 yards, reaching three figures for the first time this season, with two receiving plays of 25 or more yards.

Opponents against the Vikings have racked up a total of 2,537 yards, giving the Minnesota defense the sixth-worst record in that regard. The Vikings are also allowing 32 plays of at least 20 yards – with only five teams in the NFL conceding more.

Tight end – George Kittle, San Francisco 49ers @ Arizona Cardinals

Utilised predominantly as a blocker in Week 10, George Kittle should see more of the ball against a Cardinals defense that has allowed a total of 2,619 passing yards this season, behind only the Atlanta Falcons and the Titans, and 17 passing touchdowns, the fourth-most across the NFL.

When targeted, Kittle is a reliable option to get the ball moving downfield, catching 29 of 41 targets and securing a first down on over half of them (15). A total of 340 yards this season has seen 165 yards after catch, illustrating his power when he gets moving.

Kittle boasts a burn rate, which is when a receiver wins his matchup against a defender on a play where he is targeted, of 65.9 per cent – ranking seventh among tight ends who have been targeted at least 30 times.

Defense/Special teams – Philadelphia Eagles @ Indianapolis Colts

Defeat to the Washington Commanders in Week 10 brought an end to the Eagles' eight-game winning streak but the 4-5 Colts should be an easier proposition for the NFC favourites to deal with.

The Eagles defense has allowed just 1,813 passing yards overall, the second-best record behind the Denver Broncos (1,769). Philadelphia's 13 interceptions is the joint-best tally in the NFL along with the Bills – intercepting 4.1 per cent of passing attempts they have faced.

Only three teams have recorded more sacks than the Eagles (29) this season, with opponents losing a total of 214 yards in the process – only the Tampa Bay Buccaneers (217) and Cowboys (225) have seen opponents lose more yards on sacks.

Elijah Mitchell believes he and Christian McCaffrey could form the best running back tandem in the NFL after he returned in style in the San Francisco 49ers' 22-16 win over the Los Angeles Chargers.

Mitchell, the 49ers' leading rusher as a rookie in 2021, had been sidelined since Week 1 with a knee sprain.

His position as San Francisco's leading back looked to have been taken by McCaffrey last month when the 49ers traded four draft picks to acquire the former All-Pro in a deal with the Carolina Panthers.

However, the pair split carries as the 49ers prevailed in primetime despite an uneven offensive performance. Mitchell carried the ball 18 times for 81 yards and McCaffrey 14 times for 38 yards and a touchdown, the latter also had four catches for 39 yards.

The 49ers finished with 157 yards on the ground but at an average of just 3.8 yards per carry, however, Mitchell is confident he and McCaffrey can take their rushing attack to great heights.

"At the end of the day, it helps both of us and like I said, year six and he's an unbelievable back," Mitchell said of McCaffrey's arrival. "I get to learn from him so I'm excited for it.

"We could be the best duo of backs in the league, in my opinion."

The 49ers' victory moved them to 5-4, trailing the Seattle Seahawks (6-4) by just half a game in the race for the NFC West title.

That record is identical to that of the Chargers, who could not overcome critical injuries on the offensive side of the ball to the likes of Keenan Allen and Mike Williams.

San Francisco's vaunted defense dominated and shut out the Chargers in the second half, and running back Austin Ekeler refused to blame the Chargers' injuries for their struggles.

"We got some of our guys who are down," Ekeler said. "I get it. That doesn’t matter. . . . No one really created today.

"We need more playmaking. We didn't have that in the second half. We can't just go out there and play hard. That doesn't win in the NFL."

The San Francisco 49ers had a dominant second half to end the Los Angeles Chargers' dominance over them with a 22-16 victory at Levi's Stadium on Sunday.

The Niners' running game came to the fore in the second half, taking the lead for the first time with 7:54 remaining in the fourth quarter after Christian McCaffrey's touchdown.

San Francisco went 12-0 in the second half, turning around a 16-10 half-time deficit, ending the Chargers' five-game streak against them. The win means San Francisco claimed back-to-back victories to improve to 5-4, while the Chargers dip to 5-4 having lost two of their past three games.

The Niners enjoyed more possession, rushing for 157 yards compared to the Chargers' 51, with Elijah Mitchell (89 yards on 18 carries) and Deebo Samuel (27 yards on four carries) contributing well on their returns from injury.

Niners quarterback Jimmy Garoppolo completed 15 of 23 passes for 197 yards with no touchdowns or interceptions, although he ran in a TD late in the first half.

Garoppolo linked up with Brandon Aiyuk, who had six receptions for 84 yards, on a 24-yard pass leading to McCaffrey's decisive rushing two-yard TD.

The Chargers scored on the opening drive of the game when QB Justin Herbert pinpointed DeAndre Carter on a 32-yard deep left pass.

In the final two minutes, a one-handed Josh Palmer could not reel in a desperate fourth-down pass from Herbert, who finished the game on 21-of-35 passing for 196 yards with one TD and one interception, before Robbie Gould made it a six-point game with a 20-yard field goal.

The San Francisco 49ers are getting healthy at the right time as they bid to kick-start a second-half surge towards the postseason and get a rare win over the Los Angeles Chargers on Sunday.

San Francisco had their bye in Week 9, having got to 4-4 in emphatic fashion a week earlier, routing the Los Angeles Rams 31-14 at SoFi Stadium.

They return home to Levi's Stadium to face the Chargers in primetime and, while they have beaten the Rams eight times in a row in the regular season, they have not had such fortune against the other Los Angeles team in the NFL.

Indeed, the Chargers are looking to win their sixth straight game against the 49ers, which would make them the first team to do so since the Seattle Seahawks (who nine games from 2014 to 2018).

However, the two teams have not met since Los Angeles' home win in Week 4 of the 2018 season.

The 49ers, who have once again battled the injury bug in a recurring theme of head coach Kyle Shanahan's tenure, are set to get eight players back from absences.

Versatile star wide receiver Deebo Samuel (hamstring), Jauan Jennings (hamstring), fullback Kyle Juszczyk (finger) and linebacker Dre Greenlaw (calf) are all set to return after missing the win over the Rams.

Running back Elijah Mitchell, linebacker Azeez Al-Shaair, backup tackle Colton McKivitz and defensive end Jordan Willis will also make their comebacks from injuries that saw them placed on the injured reserve list.

Mitchell has not played since injuring his knee in Week 1, and it is his and Samuel's infusion back into the lineup that will be most intriguing to watch from an offensive standpoint for San Francisco.

Neither Samuel nor Mitchell has had the chance to play with 49ers running back Christian McCaffrey, whom San Francisco acquired in a blockbuster trade with the Carolina Panthers last month.

In his second game against the Rams, McCaffrey threw for, rushed for and caught a touchdown. He was the first player to do so in the same game since the Chargers' LaDainian Tomlinson completed the feat in Week 6 of the 2005 season and only the fourth since the 1970 merger.

Adding Samuel, whose ability to excel as a receiver and a running back propelled the Niners to the NFC Championship Game last season, and 2021 leading rusher Mitchell into the mix alongside another dual running and receiving threat in McCaffrey opens an array of options for Shanahan, especially against a Charger run defense allowing the most yards play (5.7) on the ground in the NFL.

In contrast to the 49ers' improving injury report, the Chargers will again be without top wide receivers Keenan Allen and Mike Williams, while right tackle Trey Pipkins is out with a knee injury. Practice squad lineman Foster Sarell could get the nod in his stead ahead of much-maligned backup Storm Norton.

Despite losing left tackle Rashawn Slater to a torn ACL earlier in the season, the Chargers' offensive line has held up well. Quarterback Justin Herbert was not sacked in the win over the Atlanta Falcons in Week 9, and the Chargers have allowed the fewest sacks in the league this season (10). They have not given up 10 or fewer sacks through eight games since the 2008 season (also 10).

That could change against a fearsome 49ers defensive front. The Niners are third in the NFL with a sack rate of 8.9 per cent, though they are once again missing their best interior pass rusher, Arik Armstead, with a foot injury.

The lack of receiving weapons and injuries up front would appear to put Herbert and the 5-3 Chargers in a tough spot. However, the 49ers will be wary of Herbert's ability to overcome adversity, as he has continued to thrive even as the Chargers have failed to deliver since he entered the league in 2020.

Through 40 career starts, Herbert has accounted for 90 touchdowns (82 passing, 8 rushing). Only Patrick Mahomes (107), Dan Marino (95) and Kurt Warner (91) accounted for more scores in their first 40 starts.

We are somehow already at Week 10 in the NFL season, all wondering where the time actually does go.

Two of the shining lights of the campaign face off in Buffalo as the Bills host the Minnesota Vikings.

History will be made in Munich as the Tampa Bay Buccaneers face the Seattle Seahawks in the first-ever regular season NFL game played in Germany, while the San Francisco 49ers will look to continue their return to winning ways against the Los Angeles Chargers.

Stats Perform takes a closer look at the numbers behind some of Sunday's NFL clashes.

Minnesota Vikings (7-1) @ Buffalo Bills (6-2)

The Vikings have played eight games at Highmark Stadium and have held the Bills to 23 points or fewer in each one, which is the longest streak of allowing 23 points or fewer by a visiting team in the stadium's history.

Minnesota have won six straight games, all by eight points or fewer, tied for the second-longest streak of one-possession wins in NFL history, behind a seven-game streak by the Kansas City Chiefs in 2020.

T.J. Hockenson boasted nine catches on his Vikings debut last week, tying the Bills' Keith McKeller (October 18, 1987) for the most receptions by a tight end on debut with a team in the Super Bowl era.

The Bills have allowed 21 points or fewer in 12 straight regular-season games, the longest streak in franchise history and the second longest by any NFL team over the last 15 seasons (Baltimore Ravens, 13 straight from 2019-20).

Buffalo are allowing just 4.6 points per game in the second half this year. No NFL team has allowed fewer than 5.0 points per game in the second half over a full season since the Carolina Panthers in 1996 (3.5).

Seattle Seahawks (6-3) @ Tampa Bay Buccaneers (4-5)

It should be a great experience in Bavaria, but the Bucs are 0-3 in games played outside the United States (all in London), having been outscored 96-51 in those games. The Seahawks, meanwhile, are 2-0 outside the U.S. (one in Toronto, one in London), outscoring their opponents, 77-20.

Pete Carroll is in his 17th season as an NFL head coach and has had at least six wins in each campaign. The only other coach to have six or more wins in each of his first 17 seasons was Don Shula, who did so in all 33 seasons of his career.

Kenneth Walker III is the first NFL rookie to rush for a touchdown and have his team win in each of his first four career starts since Robert Edwards for the New England Patriots in 1998.

Tom Brady has thrown at least 40 passes with no interceptions in seven consecutive starts. No other QB in NFL history has done that in more than four straight starts.

The Bucs have rushed for 75 or fewer yards in eight straight games, the second-longest streak in the Super Bowl wera behind a nine-game streak by the Cardinals from 1991-92.

Los Angeles Chargers (5-3) @ San Francisco 49ers (4-4)

The Chargers are looking to win their sixth-straight game against the 49ers, which would make them the first team to do so since the Seahawks (nine games from 2014 to 2018).

Justin Herbert was not sacked in the Chargers' recent win against the Atlanta Falcons. The Chargers have allowed the fewest sacks in the league this season (10), and have not allowed 10 or fewer sacks through eight games since the 2008 season (also 10).

Through 40 career starts, Herbert has played a part in 90 touchdowns (82 passing, eight rushing). Only Patrick Mahomes (107), Dan Marino (95) and Kurt Warner (91) accounted for more scores in their first 40 starts.

San Francisco's last five games have all been decided by at least 14 points (3-2 record). They have not had six consecutive such games since an eight-game streak in 1999.

Christian McCaffrey threw for, rushed for and caught a touchdown in San Francisco's win over the Rams. He was the first player to do so since the Chargers' LaDainian Tomlinson completed the feat in Week 6 of the 2005 season.

Elsewhere...

The Jacksonville Jaguars (3-6) will need a plan to deal with Chiefs (6-2) QB Mahomes, who attempted 68 passes (completing 43) in last week's win over the Tennessee Titans, both of which set single-game team records. The only player to attempt more passes in a win in the NFL since 1950 was Drew Bledsoe with 70 in Week 11 of the 1994 season.

Former Chief Tyreek Hill has 1104 receiving yards this season for the Miami Dolphins (6-3), the most by any player through his team's first nine games in the Super Bowl era. Prior to this year, there had only been 11 times a Dolphins receiver recorded 1100 yards in an entire season, and Hill will look to add to those against the Cleveland Browns (3-5).

Last week was Cooper Kupp's 20th career game with at least 100 receiving yards and a touchdown, the most in the NFL since he entered the league in 2017. The only other players with more than 15 such games in that span are Davante Adams (19) and Hill (18), and the Los Angeles Rams (3-5) will need their star to step up again against the Arizona Cardinals (3-6).

Aaron Rodgers' passer rating is at 89.0 this season after posting 111.9 in 2021. The decrease of 22.9 is the largest by a Green Bay Packers quarterback (min. five games played) since Bart Starr from 1966 to 1967 (105.0 to 64.4). With a record of 3-6, the Packers will hope he can improve that against the Dallas Cowboys (6-2).

John McVay, an executive with the San Francisco 49ers who played a key role in building the franchise’s dynasty four decades ago, died Tuesday at age 91.

McVay joined the 49ers in 1979 and spent 22 seasons with the franchise, holding various jobs including general manager and director of football operations.

Under his direction, the 49ers won five Super Bowl titles in a 14-season span and McVay was named The Sporting News NFL Executive of the Year in 1989 after the team’s fourth Super Bowl championship.

The 49ers inducted McVay into the team Hall of Fame in 2013 and dedicated the draft room at the team’s headquarters in his honour in 2016.

''This is a very sad day for our organization and the entire football community,'' the team said in a statement. ''John McVay was a driving force in constructing teams for our five Super Bowl titles.

"Most importantly, John was a Hall of Fame person who built genuine and sincere relationships with front office staff, coaches and players. John's commitment and contributions to the 49ers created the standard and tradition we strive to carry on today. Our thoughts and prayers are with the McVay family.''

McVay is the grandfather of current Rams coach Sean McVay.

The Miami Dolphins have acquired edge rusher Bradley Chubb from the Denver Broncos, sending a package that includes a first-round pick in a blockbuster trade.

According to ESPN's Adam Schefter, Miami parted with the 2023 first-round pick they received from the San Francisco 49ers in the trade that facilitated the Niners moving up in the 2021 draft to select quarterback Trey Lance third overall.

In addition, the Dolphins sent a 2024 fourth-round pick and running back Chase Edmonds in exchange for Chubb and a 2025 fifth-round pick.

The Dolphins will hope Chubb can provide a significant boost to a defense that has allowed 5.89 yards per play, the seventh-most in the NFL, and tallied 14 sacks for negative yardage, only good enough for a five-way tie for 20th.

Their pressure rate of 39.6 per cent is above the NFL average, but Chubb will be tasked with improving Miami's ability to convert those pressures.

This season the 2018 first-round pick has registered 5.5 sacks, eight quarterback hits, four tackles for loss and two forced fumbles for a stellar Denver defense, the efforts of which have been wasted by continued poor performances on offense.

Denver beat the Jacksonville Jaguars in London last Sunday to improve to 3-5, still a hugely disappointing record for a team that had hoped to make the leap after sending five picks, including two first-rounders, and three players to the Seattle Seahawks for nine-time Pro Bowl quarterback Russell Wilson.

But the struggles of the Wilson-led attack created talk of them being sellers at the trade deadline. No team will be able to make trades after 16:00 EST on Tuesday.

Such speculation proved accurate, with the 5-3 Dolphins landing a pass rusher who is tied 10th in adjusted sack rate among players with at least 50 edge snaps, according to Stats Perform data.

Chubb figures to form an imposing duo with second-year edge rusher Jaelan Phillips, whose pressure rate of 27.6 per cent is the fifth-best in the NFL for edge rushers (minimum 50 snaps).

The Dolphins face the Chicago Bears in Week 9 at Soldier Field, where Chubb could make his debut.

Following the move for Chubb, the Dolphins also struck a deal with the 49ers for running back Jeff Wilson Jr, sending a fifth-round pick to San Francisco.