The Los Angeles Chargers survived a late scare to defeat the Cleveland Browns 30-28 on Sunday afternoon thanks to a massive performance from running back Austin Ekeler.

Ekeler finished with two of the Chargers' three touchdowns, rushing for 173 yards and a score from 16 carries, and adding 26 yards and a touchdown from four catches.

Both times Ekeler scored he put the Chargers back into the lead in a rollercoaster of a game, where the Browns jumped out to a 14-0 lead in the first quarter through touchdowns to focal points Amari Cooper and Nick Chubb.

Chubb's second rushing touchdown gave the Browns a 17-14 lead at half-time, and they were up 28-27 going into the fourth quarter after Kareem Hunt converted a goal-line carry for a touchdown of his own.

Taylor Bertolet's field goal put the Chargers back in front with nine minutes to play, finishing three-for-three with his kicks for the day, and the game looked to be sealed when Browns quarterback Jacoby Brissett threw an interception with under three minutes on the clock.

Needing a couple of first downs to put on the finishing touches, the Chargers were presented with a fourth-and-one at their own 46-yard line, and instead of punting and playing it safe, they went for it and failed.

A short completion gave the Browns a 54-yard field goal opportunity to win the game in the final seconds, but it drifted wide right, with kicker Cade York missing both of his attempts for the game.

Chargers quarterback Justin Herbert completed 22 of his 34 passes for 228 yards and a touchdown with no turnovers, with his top receiver Mike Williams catching 10 for 134 yards.

Chubb was the offensive star for the Browns, carrying 17 times for 134 yards and two touchdowns.

Bills blow away the Steelers

The Buffalo Bills took their foot off the gas in the second half to coast to a dominant 38-3 victory against the Pittsburgh Steelers.

Wide receiver Gabriel Davis was the star of the show along with quarterback Josh Allen, combining on a 98-yard passing touchdown just 64 seconds into the game. It was the longest touchdown in the NFL this season.

They were not finished there, linking up again to begin the second quarter with a 62-yard touchdown.

Allen added two more touchdown passes in the first half – one to Stefon Diggs and one to Khalil Shakir – to open up a 31-3 lead at the long break, and from there they were never tested.

Another Dolphins quarterback leaves with concussion

Making his first start of the season after Tua Tagovailoa was sidelined with his concussion last week, Miami Dolphins quarterback Teddy Bridgewater was pulled after the first play in a 40-17 loss to the New York Jets.

Bridgewater was evaluated for a concussion and could not return, handing rookie Skylar Thompson his first snaps as a professional. 

Neither team threw for a touchdown in the game, with the Jets rushing for five scores as exciting rookie Breece Hall finished with 18 carries for 97 yards and a touchdown, adding two catches for 100 yards, and goal-line back Michael Carter pushed his way in for two touchdowns.

Adding to the great day for Jets fans was the fourth overall pick from this year's NFL Draft, cornerback Sauce Gardner, recording his first career interception.

Brian Robinson Jr. made his NFL bow on Sunday, as the Washington Commanders rookie played his first game just six weeks after he was shot twice.

The running back survived an attempted robbery in the capital on August 28 and has not played since, but was activated from the non-football injury list ahead of this weekend's game with the Tennessee Titans.

Brought on to a hero's welcome at FedExField, the third-round pick was unable to prevent another loss, which leaves the Commanders' record at 1-4 after a 21-17 defeat.

But Robinson nevertheless notched solid numbers for the NFC East outfit, posting 22 yards from nine carries with an average 2.4 gain.

The 23-year-old will hope his performance earns him further game-time over the coming weeks, with Washington set to travel to the Chicago Bears on Thursday night.

Matt LaFleur conceded he did not call a good enough game as a head coach after the Green Bay Packers' collapse in their shock 27-22 defeat to the New York Giants.

Playing in their first game in the United Kingdom, the Packers looked in command at Tottenham Hotspur Stadium after building a 20-10 half-time lead.

From there, however, the Packers scored just two points, which came on an intentional safety given up by the Giants at the end of the game, as New York produced a remarkable comeback.

A 15-play, 91-yard drive capped by a two-yard rush for Gary Brightwell saw the Giants tie the game at 20-20 before Saquon Barkley, who finished with 106 yards from scrimmage, averaging over six yards per touch, gave New York the lead with a two-yard run on a direct snap.

Green Bay responded with a drive to the Giants' six-yard line but failed to punch in the tying score, Aaron Rodgers seeing a fourth-down throw to Allen Lazard batted down before he was sacked on a failed Hail Mary attempt in the final seconds.

The Packers had dictated matters in the first half through the ground attack and the short passing game, but the run was a non-factor in the second, as Green Bay was forced to punt after gaining only 46 yards on their first two drives before the failed effort to tie the game.

While LaFleur credited the Giants' defense and their coordinator Wink Martindale for forcing the Packers away from the run, he did take responsibility for an anaemic second-half showing.

Asked if he anticipated going pass-heavy, LaFleur told his post-game press conference: "Just depended upon what they were giving us. Like I said, we had a lot of run-pass cans [options].

"They played a lot of single high [safety coverages], manned us up. Do you want to run into a loaded box or try to get it through the air?

"Unfortunately that didn't work for us. Like I said, give credit. Wink is a guy I got a lot of respect for. He out-coached us in the second half, and they outplayed us.

"Give New York all the credit. They out-coached us, they outplayed us. They definitely wanted it more. It was the tale of two halves. They kicked our butt in the second half. You can't do that in this league.  

"Obviously the plan and the play calls that I gave weren't good enough. 

"We just got to regroup. Everybody's got to look in the mirror and ask themselves what they can do better because it was a collective effort right there in terms of not being able to come out on top. 

"They kept playing. Give New York a ton of credit. I don't think the mindset for our guys was ever to let up. Certainly you look at the results out there. There was too many mistakes. It wasn't just one person; it was a collective effort like I talked about.  

"It starts with myself. I got to be better. I got to be better for this team. We got to demand that we get better in certain areas. It's just disappointing."

The New York Giants produced a stunning comeback to upset the Green Bay Packers 27-22 and move to an improbable 4-1 with victory at Tottenham Hotspur Stadium.

Green Bay, playing in the United Kingdom for the first time in front of a raucous crowd dominated by Packer fans, dominated the first half and led 20-10 at half-time.

Two touchdown throws from Aaron Rodgers to Allen Lazard and Marcedes Lewis along with a pair of Mason Crosby field goals seemingly had Green Bay in command.

The second of those three-pointers came after the Giants' first touchdown drive, capped by a double reverse touchdown by tight end Daniel Bellinger, which served as a harbinger of what was to come in the second half.

A field goal from Graham Gano cut the deficit to seven points and, after a Dexter Lawrence sack stopped a promising Packers drive, the Giants drove 91 yards on 15 plays with star running back Saquon Barkley back in the locker room nursing a shoulder injury, Gary Brightwell's two-yard rushing touchdown tying the game. 

Barkley returned for the next drive after a quick Packers three-and-out and, having set up the Giants' first score with a 40-yard scamper, he gave New York the lead, getting them into the red zone with a 41-yard catch-and run before taking a direct snap two yards to complete the turnaround.

Green Bay responded with a drive deep into Giants' territory but, on fourth-and-one from the New York six, Rodgers saw his pass to Allen Lazard batted into the air, sealing a remarkable win to drop the Packers to 3-2, an intentional late safety taken by Brian Daboll's men proving immaterial.

The NFL and NFL Players Association have agreed to modify concussion protocols following an investigation of Tua Tagovailoa's recent injury, saying his return to a game against the Buffalo Bills was "not what was intended when the protocols were drafted".

Although the investigation found the Miami Dolphins to have followed existing protocols "as written", NFLPA president J.C. Tretter believes Tagovailoa's treatment was not a "meaningful application" of the rules.

The Dolphins came under heavy scrutiny for their decision to field Tagovailoa against the Cincinnati Bengals in Week 4, a game in which he sustained a concussion.

In Tagovailoa's previous outing against the Bills, he appeared unsteady on his feet after his head slammed against the turf following a heavy collision. 

The NFL and NFLPA launched an investigation into the handling of that injury after he returned to the field shortly thereafter, with head coach Mike McDaniel saying he suffered a back injury.

A joint NFL-NFLPA statement released on Saturday read: "The parties have completed their joint review of the application of the NFL's concussion protocol following the injury to Miami Dolphins Quarterback Tua Tagovailoa during their game on September 25, 2022.

"While the investigation determined that the team medical staff and unaffiliated medical professionals followed the steps of the protocol as written, the NFL and NFLPA agree that the outcome in this case is not what was intended when the protocols were drafted.

"As such, as has been done in previous cases, based on the advice of the parties' respective medical experts, the protocol will be modified to enhance the safety of the players.

"Specifically, the term 'ataxia' has been added to the mandatory 'no-go' symptoms. If a player is diagnosed with 'ataxia' by any club or neutral physician involved in the application of the concussion protocol, he will be prohibited from returning to the game.

"The parties remain committed to continuing to evaluate our protocol to ensure it reflects the intended conservative approach to evaluating player-patients for potential head injuries."

Tretter, however, has since taken to social media to criticise the Dolphins' handling of the incident, tweeting: "We do not believe this was a meaningful application of the protocols. 

"Nobody, including the NFL, believes he should have been put back in the game. It is problematic that he was cleared for a back injury for which the lead doctors never took the time to examine."

Tagovailoa has been ruled out of the Dolphins' Week 5 fixture against the New York Jets on Sunday.

London could be home to two NFL teams if a European division of American football's premier league gets off the ground.

The NFL first started playing international games in 2007 with the goal of turning the league into a truly worldwide brand. Fifteen years later, commissioner Roger Goodell continues to field questions about the final goal of that effort.  

Could the NFL become a trans-Atlantic league with franchises in Europe? It appears the answer is that yes, it could, if not quite yet.

Speaking to fans on a panel with former players Osi Umenyiora, Victor Cruz and Maurice Jones-Drew, Goodell spoke positively about the possibility of an NFL franchise – or two – calling the UK home.

"I think there's no question that London could support not just one franchise, I think two franchises, I really believe that," Goodell said. "That's from a fan perspective, a commercial standpoint, from a media standpoint, I think you [the UK fans] have all proven that."

The Green Bay Packers will become the last of the NFL teams to have played a game in the UK when they face the New York Giants on Sunday at Tottenham Hotspur Stadium, the second of three games this year in London.

On October 30, the Denver Broncos and Jacksonville Jaguars will play at Wembley Stadium.

The NFL will also play its first ever game in Germany next month when Tom Brady and the Tampa Bay Buccaneers face the Seattle Seahawks at Allianz Arena in Munich.

The panel's host, Neil Reynolds of Sky Sports, joked that the NFL should have an entire division based in Europe, an idea well received by Goodell.

"That's part of what we're doing, right?" Goodell said. "We're trying to see 'could you have multiple locations in Europe where you could have an NFL franchise?', because it would be easier as a division."

Despite the success of the NFL's International Series, the primary concern with its expansion remains competitive balance.

"The question I think is going to come down to, not so much the logistics about travel, that's clearly a challenge, it really comes down to whether you can do it competitively, where the team here or the teams in the States coming over can continue to be competitive, and that was the challenge when we did the regular-season games," Goodell said.

"There was a lot of concern with ownership when we first introduced it, and frankly it took the guts of the Giants and Dolphins that came out here the first time, they had to prove we could do it competitively.

"This is where it turned around [for the 2007 Giants] and they went and won the Super Bowl that year. That sent a message to everybody in the league – it's not going to damage your ability to make it to the postseason. Competitiveness is the key."

The Los Angeles Rams did not give Sean McVay much reason to be confident they can find their Super Bowl-winning form during their Monday defeat to the San Francisco 49ers.

San Francisco rode a dominant defensive performance to knock off the Rams 24-9, extending the 49ers' regular-season winning streak against their NFC West rivals to seven games.

Matthew Stafford failed to throw a touchdown pass having also drawn a blank in the Week 3 win over the Arizona Cardinals. It marked the fourth time in his career that Stafford had gone without a scoring throw in successive games.

Yet even with their offense misfiring, the Rams and head coach McVay have reason for hope heading into Sunday's clash with the Dallas Cowboys.

Since McVay took over in 2017, the Rams have gone 3-1 against the Cowboys, including a win in the Divisional Round of the playoffs at the end of the 2018 season.

Los Angeles' average margin of victory in those successes has been 16 points and, going against a backup quarterback in Cooper Rush, the Rams would appear to be a strong bet for a two-touchdown win in this matchup.

Yet Rush is proving himself a top-tier backup as Dak Prescott recovers from a thumb injury.

He has helped the Cowboys to three successive victories after they lost the season opener to the Tampa Bay Buccaneers. Having won his first start against the Minnesota Vikings last year, Rush is the first quarterback in Cowboys history to win his first four starts. The only other NFL players to do so since 2005 are Kyle Allen (5), Patrick Mahomes (6), Jimmy Garoppolo (7) and Trevor Siemian (4).

And Rush and the Cowboys may have a formula for making it five wins for their number two signal-caller.

The Rams' nine-point effort against the 49ers marked the second time they had failed to score more than 10 this season. They were held to 10 by the Buffalo Bills in the season curtain-raiser.

Los Angeles had only failed to surpass 10 points seven times in McVay's first five seasons as head coach and have not done so more than twice in one season since doing so nine times in 2016, the Rams' first year back in their Southern California home following the return from St. Louis.

In the Cowboys, however, the Rams are facing a defense that has the talent to match the destruction the 49ers produced against a banged-up offensive line that allowed Stafford to be sacked seven times and pressured on 21 dropbacks.

Heading into Week 5, the Cowboys ranked second in pass rush win rate and boast three pass rushers in Micah Parsons (4), Demarcus Lawrence (4) and Dorance Armstrong (3) who have combined for 10 sacks so far this season.

With the Rams proving incapable of protecting Stafford as they fell to 2-2 on the season in the loss to San Francisco, that trio has a chance to consistently disrupt the Rams' passing game and allow a Dallas offense that has committed just two giveaways this season to control the ball and the clock.

Should that happen at SoFi Stadium, the Cowboys will be in an excellent position to reduce the Rams' reasons for positivity by dealing another blow to their hopes of retaining the Lombardi Trophy.

The Green Bay Packers have been one of the most consistent teams in the NFL under the leadership of Matt LaFleur.

As a head coach, LaFleur has compiled a 42-11 regular-season record, winning three NFC North titles and guiding the Packers to the NFC Championship Game in two of his three campaigns in charges.

Yet the failure that has contributed to their inability to get to the Super Bowl during LaFleur's tenure has also been consistent.

In the NFC Championship Game at the end of the 2019 season, the Packers were gashed on the ground by Raheem Mostert and the San Francisco 49ers in a 37-20 blowout.

Mostert racked up 220 rushing yards and four touchdowns in a remarkable display, and a year later as the Packers hosted the Tampa Bay Buccaneers at Lambeau Field at the same stage, they suffered a similar if less statistically dramatic downfall.

Leonard Fournette only had 55 yards rushing in the Buccaneers' 31-26 win, but he had a 20-yard score in the second quarter that gave Tampa Bay a lead they never relinquished, and he averaged four yards after contact, again illustrating the Packers' struggles to stop the run.

The offense and special teams were more at fault last season as the 49ers beat the Packers at Lambeau in the Divisional Round, but a nine-yard run from Deebo Samuel gave the Niners a key third-down conversion on their game-winning drive.

When the Packers have needed to stop the run in critical games, they have come up short, and the signs of that problem being fixed in 2022 are not good.

The Packers are allowing at least four yards on 57.8 per cent of carries by their opponents, the highest rate in the NFL, and giving up 4.91 yards per rush on first down. Green Bay's rush average allowed of 4.97 yards per carry is the 11th-worst in the NFL.

Three of the Packers' first four games have seen them surrender over 100 yards rushing, conceding 167 in allowing a poor New England Patriots team to take them to overtime.

Green Bay's issue is not getting into the backfield, as the Packers rank eighth in run disruption rate, according to Stats Perform data.

So why are the Packers still having issues stopping the run? The short answer is tackling.

Their tackle success rate of 73.6 per cent is tied for the fifth-worst in the NFL, with their problems coming chiefly on the left side of their defense. Left inside linebacker De'Vondre Campbell has missed four tackles and seen a further two broken, while edge rusher Preston Smith – listed as the starting outside backer on the left side – has also had a pair of tackles broken.

It is certainly not fair to pin all the Packers' run defense struggles on Campbell, but it is clear they are not doing enough as a collective to bring ball-carriers down if they evade the disruption Green Bay creates in the backfield.

This week the Packers face the New York Giants in London and meet a running back in Saquon Barkley who is doing an excellent job of racking up yardage on plays where the defense generates a run disruption.

Indeed, Barkley, the NFL's rushing leader through four weeks, is averaging 3.54 yards per carry when faced with a run disruption, above the average of 3.02.

However, his yards after contact per attempt average of 1.96 yards is below the average of 2.01. So while he might be able to evade defenders who get behind the line of scrimmage, tackle-breaking runs from the 2018 second overall pick should be at a premium.

In that sense, he is something of a test case for the Packers. Green Bay has poured plenty of resources into the problems stopping the run but, if Barkley enjoys significant success fighting through contact at Tottenham Hotspur Stadium, it could be a sign that run defense and, more specifically, tackling is an issue that could doom a Super Bowl-ready team once more and require more targeted attention next offseason.

The Washington Commanders are set to hand rookie running back Brian Robinson Jr. his first reps against the Tennessee Titans, completing a remarkable recovery.

The third-rounder was shot twice in an attempted robbery in Washington, D.C. on August 28, where he was fortunate as the bullets passed clean through his lower body.

Robinson has undergone his first week in training after being activated from the team's non-football injury list and will immediately be elevated into the team, Ian Rapoport states.

The rookie will play back-up to starter Antonio Gibson and the plan is for Robinson to receive about 20 snaps in the Week 5 contest.

Offensive coordinator Scott Turner has been impressed by Robinson's displays and said the team is excited for him to take to the field.

"He looked great at practice. He's not going to come in and just carry the ball 30 times," Turner told reporters.

"It's his first time ever playing in the NFL too. He's a rookie, so there's going to be a period of kind of getting him going. But I think we're all excited.

"He's going to give us some juice and that physical presence and just a good all-around back."

The Commanders hold a 1-3 record in 2022 and stand as the only side in the NFC East without a winning record.

A new NFL policy on the handling of concussions is expected to go into effect any day now after the Players Association approved proposed protocol changes Friday.

The NFL and NFLPA had previously agreed to a revised protocol that would prohibit players returning to the field if they displayed signs of instability in their motor skills. The union issued a statement Friday requesting that the changes be put in place for this weekend’s games.

"Our union has agreed to change the concussion protocols to protect players from returning to play in the case of any similar incident to what we saw on September 25," the statement read. "We would like these changes to go into effect before this weekend’s game to immediately protect the players and hope the NFL accepts the change before then as well."

The September 25 incident the union referred to occurred in a game between the Miami Dolphins and Buffalo Bills, in which Dolphins quarterback Tua Tagovailoa briefly left the contest with what the team initially termed a head injury.

Tagovailoa later returned to the game after passing concussion tests, with Miami head coach Mike McDaniel saying afterward that the injury was to the quarterback’s lower back.

The Dolphins later cleared Tagovailoa to play at Cincinnati four days after the Buffalo game, and the former Alabama star was injured again on a hit from Bengals defensive tackle Josh Tupou that caused his head to hit the ground hard.

Tagovailoa was stretchered off the field and taken to hospital, and the Dolphins have since ruled him out for Sunday’s game against the New York Jets while confirming a concussion diagnosis.

The NFL later issued a statement saying it intends to also sign off on protocol changes, though it’s unclear when they will begin to be enforced.

"As we have discussed with the NFLPA, we agree that changes to the joint NFL-NFLPA protocols are necessary to further enhance player safety," the league said. "We have already spoken to members of the NFL Head, Neck and Spine Committee and the leadership of the Unaffiliated Neurotrauma Consultants and Independent Certified Athletic Trainers who serve as spotters to discuss these likely changes."

The NFL and the union remain in the process of investigating the Dolphins’ handling of Tagovailoa’s September 25 injury and have yet to determine whether the team erred in judgement or violated protocols.

Garett Bolles has added to the Denver Broncos' offensive injury woes, suffering a broken leg in the 12-9 overtime defeat to the Indianapolis Colts.

The sixth-year left tackle was forced off with just under four minutes remaining of the fourth quarter on Thursday and was seen on crutches after the game.

Initial tests revealed a broken leg, but the team were awaiting further evaluation on Friday and it was then confirmed by head coach Nathaniel Hackett that he would be out for the remainder of the season.

"Garett Bolles will need surgery. He'll be out for the season." he said.

The Broncos' offense had already lost starting running back Javonte Williams to a season-ending knee injury in a Week 4 defeat to the Las Vegas Raiders, with the injuries coming amid on-field woes for the side.

Cornerback Ronald Darby has also been ruled out for the season after suffering an ACL injury and Hackett confirmed he is set for surgery.

Defeat to the Colts left the Broncos 2-3 for the season and are they yet to find their feet under Russell Wilson, following his seismic trade from the Seattle Seahawks.

The Broncos have plenty of time to improve before they take to the field in Week 6 against division rivals the Los Angeles Chargers, the game coming on Monday October 18.

Daniel Jones is expected to be the starting quarterback for the New York Giants against the Green Bay Packers, having recovered from injury.

The fourth-year QB suffered an ankle injury in the win against the Chicago Bears in Week 4 and was briefly taken out of the game, though he made his return to training on Friday.

Jones did not receive an injury status in London on Friday, leaving him set to lead the offense at Tottenham Hotspur Stadium on Sunday.

"Early in the week I started feeling better pretty quickly and realised that I was recovering quickly," he said after practice.

While Jones should be passed fit, the Giants' offensive options have been ravaged by injuries, particularly in the wide receiver area with Wan'Dale Robinson (knee), Kadarius Toney (hamstring) and Kenny Golladay (knee) all unavailable.

Despite the Giants' aerial presence taking a hit, Jones remains optimistic, saying: "We've had guys step up throughout the year."

New York are likely to rely heavily on their rushing game again, where Jones and Saquon Barkley have offered a dual threat – the latter standing as the NFL's rushing leader in 2022.

Jones is similarly effective on the ground, having at least six rush attempts in all four contests so far this season and accumulating 193 rushing yards, plus two touchdowns, with Barkley praising the character of his QB.

"He's a gritty guy, he's a tough guy. It does speak volumes when your quarterback has that mindset." he said.

The Giants stand 3-1 heading into the matchup against the Packers, tied with the Dallas Cowboys and behind the Philadelphia Eagles (4-0) in the competitive NFC East.

The Atlanta Falcons will be without second-year tight end Kyle Pitts when they play the Tampa Bay Buccaneers for the NFC South lead on Sunday.  

The Falcons ruled Pitts out with a hamstring injury after he was held out of practice all week.  

Parker Hesse and Anthony Firkser could see more snaps at tight end, but neither option provides the vertical threat of Pitts, who was drafted fourth overall out of Florida in 2021.  

Pitts' absence is another blow for an Atlanta offense that is already missing starting running back Cordarrelle Patterson, who is out at least four games after undergoing a minor knee procedure.  

Pitts' role in the offense so far this season has been a point of contention for some Falcons fans. The 6ft 6in tight end has just 10 catches for 150 yards through four games, although he has been targeted 22 times.  

The Falcons dropped the first two games of the season but bounced back by beating the Seattle Seahawks and Cleveland Browns the past two weeks. The Buccaneers are also 2-2, coming off losses to the Green Bay Packers and Kansas City Chiefs.  

Standing as the only undefeated team across the NFL, the 4-0 Philadelphia Eagles will need to bring an end to a poor record in Arizona, having lost four consecutive matchups against the Cardinals.

The Eagles have not won in Arizona since Week 8 of the 2001 season, a 21-7 win highlighted by Brian Mitchell's 94-yard touchdown return of the opening kick-off, and will hope for similar magic on Sunday.

Miles Sanders enters the contest in fine form, setting a new career high in rushing yards last week against the Jacksonville Jaguars with 134 and scoring two rushing touchdowns for only the third time in his career (Week 5 & 14, 2020).

That saw him become the first Eagles player with 130+ rushing yards and two TDs in a single game since LeSean McCoy in Week 16, 2013, and only the sixth player to do so in the franchise's history.

This season, Sanders boasts 356 rushing yards to rank third among the league's rushing leaders behind only Saquon Barkley (463) and Nick Chubb (459) – the trio the only three players across the NFL to have 350+ rushing yards in the opening four games of the season.

However, the Cardinals have been strong against the rush this season with their opponents averaging just 87 yards per game, ranking fifth in the NFL, though only two teams have faced less rushing plays than Arizona (81).

For the Cardinals' offense, the onus will be firmly on Kyler Murray, who has attempted 173 passes this season, behind only Matt Ryan (195), whose 128 completions make him the sole quarterback to tally more than Murray (113, tied with Josh Allen).

However, a pass completion percentage of 65.3 is only enough to rank 14th in the NFL, with Murray's 991 yards leaving him 16th in the league and indicative of his bizarre lack of downfield threat. Murray's air yards per attempt average of 5.47 is the worst in the league among quarterbacks with at least 10 attempts.

The Eagles have allowed their opponents a gross passing yards total of 821, the seventh-lowest total in the NFL, so Murray will face a stern test if he is to lead the Cardinals to a fifth win in a row against their NFC rivals.

After a scintillating game between the Minnesota Vikings and New Orleans Saints last week, Tottenham Hotspur Stadium plays host to NFL action again as the New York Giants and Green Bay Packers lock horns.

The Giants travelled across the pond for Sunday's London game beset by injuries at wide receiver in their stuttering offense.

No receiver had 20 or more yards in their 20-12 victory over the Chicago Bears last week.

It was the second time in six games that has happened for New York, the team having had just one such instance over their previous 231 outings, but they still improved to a surprise 3-1 record.

Victory against the Bears came with just 71 passing yards, with the Giants yet to have over 200 passing yards in a game so far this season.

Their gross passing yards total this term stands at 642, the second-lowest tally across the NFL behind only the struggling Bears (471).

Rushing has been the name of the game for the Giants offensively.

They boast the NFL's most net rushing yards (770), the fourth-most average carries per game (33.5) and the second-highest average gain per carry (5.75).

While the Packers are heavy favourites to slow New York’s fast start to the season, the odds of them halting running back Saquon Barkley's renaissance look slim.

No player in the NFL is averaging more yards per game than Barkley's 115.8, while a Packers defense that has traditionally struggled against the run is surrendering 4.97 yards per rush, the 11th-most in the league.

Packers linebacker Rashan Gary will be part of a defense hoping to prevent the Giants' charge after recording two sacks in the 27-24 overtime win against the New England Patriots.

He has at least one sack in all four of Green Bay's contests this season and no Packers player has ever registered a sack in each of the opening five games of a campaign.

In total, the Packers, who also hold a 3-1 record, have 11 sacks this season, five of which have come from Gary himself.

Only six teams have more than Green Bay's sack total and just three NFL players have more than Gary so far in 2022.

Offensively, Aaron Rodgers has already racked up some big gains with the Packers recording 17 passes of 20 or more yards this season, only behind the Detroit Lions (18) and Denver Broncos (21).

The veteran QB had two passing TDs in each of his last three contests, all of which have been victories for Green Bay as they bounced back well from a disappointing opening loss to the Vikings.