Mako Vunipola will start for Saracens in their Premiership clash with Leicester Tigers on Saturday after being omitted from England's Six Nations squad to face Wales on "medical grounds".

England stood Vunipola down on the advice of their medical team amid concerns over the spread of the coronavirus, the prop having briefly travelled through Hong Kong en route home from a trip to visit family in Tonga.

Though Vunipola was not placed in self-isolation and had not reported any illness, England felt it was best to leave him away from their "camp-based environment" ahead of Saturday's encounter at Twickenham.

Saracens took a different view, though, explaining that they followed guidance from the health authorities and that neither Mako Vunipola nor his injured brother Billy had "displayed symptoms of the coronavirus" following assessments.

Mako Vunipola will therefore take his place in Saracens' starting XV for the visit of Leicester.

Saracens are bottom of the table due to their 105-point deduction over salary cap breaches while the Tigers are directly above them in 11th, having won just four of their 12 fixtures to date.

Montpellier outside back Nemani Nadolo has agreed to join Leicester Tigers, while brothers Ben and Tom Youngs have signed new deals with the Premiership club.

A powerful runner, clinical finisher and accurate goal-kicker, former Fiji powerhouse Nadolo will move to Welford Road ahead of the 2020-21 season.

The prolific Nadolo, who can play on the wing or as a centre, has racked up over 1,000 points in domestic rugby and scored in excess of 150 professional tries.

Tigers head coach Geordan Murphy said after landing the 32-year-old: "It's certainly one to get excited about, no matter who you are.

"He's a star of the international game and a player that crowds all over the world have been able to enjoy see play.

"Now, the Tigers faithful get that chance and the playing squad, as well as coaching staff, get the opportunity to work alongside and with Nemani from next season."

England scrum-half Ben Youngs and his older sibling, Tigers captain Tom, will line up with Nadolo next season after committing their futures to the club.

Murphy said: "Ben is Tigers through and through and, for more than a decade, has given everything for the badge.

"To have him recommit is sensational for everyone in Leicester; players, coaches, staff and fans."

He added of the skipper: "Tom is everything you can ask for and more in a club captain.

"His leadership and experience are imperative to what we are building here in Leicester and passion for Tigers is unrivalled."

Sale Sharks moved up to second in the Premiership with an easy 36-3 win over Leicester Tigers.

Second-bottom Leicester took the lead through Noel Reid's penalty but it was all downhill thereafter.

Marland Yarde's try was sandwiched between efforts from Bryn Evans and Coenie Oosthuizen as Sale took command and the wing scored each of the Sharks' second-half tries to complete his hat-trick.

Wasps routed already-relegated Saracens 60-10 in Friday's other game to go seventh.

Zack Kibirige and Brad Shields crossed for doubles while Jimmy Gopperth tallied 20 points with the boot as Wasps went level with Gloucester on 23 points in the fight for the European Challenge Cup places.

Curtis Rona scored a pair of tries as London Irish secured a 29-15 derby win at Harlequins, while Premiership high-flyers Sale Sharks were brought back down to earth by beleaguered Saracens.

Irish stunned title contenders Northampton Saints last time out and followed that up with a convincing bonus-point victory at The Stoop on Saturday.

Rona laid on the opening try for Matt Rogerson in treacherous conditions and the all-action wing grabbed his first of the afternoon after brilliant work from Ben Meehan.

A Marcus Smith penalty was Quins' only score of the first half and they were 17-3 down at the break after Stephen Myler was on the target from the tee at the other end, having converted both tries.

Alex Dombrandt powered his way over to reduce the deficit, but Rona dotted down again and Ollie Hoskins bagged the bonus point after Cadan Murley helped himself to Quins' second try in west London.

Sale missed the chance to move ahead of Northampton into second spot, going down 36-22 to champions Saracens at Allianz Park after beating leaders Exeter Chiefs in their previous match.

Rhys Carre, Rotimi Segun, Nick Isiekwe and Richard Barrington touched down for Saracens, while fit-again full-back Alex Goode shone in his first Premiership match of the season.

Wasps were beaten 18-9 by fellow strugglers Leicester Tigers at the end of a week that saw director of rugby Dai Young step back from first-team duties, while Bath edged out Worcester Warriors 22-21.

Sale Sharks survived a second-half fightback from Exeter Chiefs to secure a hard-earned 22-19 victory over the Premiership leaders.

Having headed into Saturday's encounter on the south coast without a defeat in all competitions since November, Exeter found themselves trailing 22-5 at the interval after a blistering first-half display from the visitors.

With Tom O'Flaherty sent to the sin bin early on Exeter, Sale ran in three tries in the first half – Chris Ashton, Daniel du Preez and Byron McGuigan getting on the scoresheet.

Rob du Preez added a further seven points, though Phil Dollman's try had handed the Chiefs some hope and Exeter gained 14 points in the space of seven minutes to set up a grandstand finale.

But Sale held firm, clinching a victory that lifted them into third, four points behind Exeter.

Elsewhere, Wasps ran in three tries in the second half to come from behind and edge out Worcester Warriors 30-26, with Dan Robson's late try proving decisive in a bonus-point win.

Wasps are eighth, level on points with the Warriors and three shy of Bath, who just got the better of Leicester Tigers – Tom Homer's double ultimately securing a 13-10 victory.

Meanwhile, Bristol Bears snapped a three-match losing streak with a convincing 34-16 triumph over west country rivals Gloucester, who slipped into fourth.

Callum Sheedy kicked 19 of the Bears' points, converting five penalties in the first half, with Bristol going over three times after the break.

Steve Borthwick is to take over as head coach of Leicester Tigers with Geordan Murphy appointed as director of rugby.

Murphy was appointed as full-time coach in December 2018 after an interim stint but the Tigers have struggled badly this season and are second bottom of the Premiership table with just two wins from 11 matches.

The Tigers have consequently opted for a reshuffle which will see Borthwick move to Welford Road at the end of his commitment to England.

Borthwick was forwards coach for an England side who reached the Rugby World Cup final and is working as skills coach under Eddie Jones for the upcoming Six Nations.

"The last four-and-a-half years working with the England team has been an incredible journey. I have worked with some brilliant players and staff," Borthwick told Leicester's official website. 

"In particular I would like thank Eddie Jones. To have worked with one of the greatest head coaches in the world for so long has been an unbelievable experience.

"I am delighted to be joining Leicester Tigers as head coach. The Tigers have such a long and successful history and are one of the greatest rugby clubs in the game. 

"Welford Road, with the special atmosphere created by the club's incredible supporters roaring their team forward, is a very special place to be.

"We must now work to build upon that great history and create our future to get this club to the top of European rugby. It is a brilliant challenge and I am excited to start working with the players and everybody associated with the team.

"Geordan provides a link with the club's greatest teams and we will be working together to ensure that there are many successful days ahead for this club, and for our supporters to enjoy."

Murphy enjoyed a legendary playing with the Tigers, winning eight Premiership titles and back-to-back Heineken Cups and the Irishman welcomed the addition of Borthwick.

"The players and staff have all been working incredibly hard to get the club back on a pathway to where we all want to be, at the top of the professional game," Murphy said.

"We have been building a lot of the foundations around recruitment and retention of the playing squad and the success of our academy structure, and we look forward to Steve's arrival to drive the playing squad onwards.

"Steve is a world-class coach with the skills and determination to get the best out of everyone around him."

Relegation-threatened Saracens bounced back from a defeat to Premiership leaders Exeter Chiefs with a 62-5 thrashing of Worcester Warriors, while there were also wins for Leicester Tigers and Gloucester on Saturday.

Champions Sarries have now collected more points this season than Exeter, but a 35-point deduction for breaching salary-cap regulations means they remain bottom of the pile and in the red.

However, the beleaguered the London club are making swift progress in their survival bid and scored 10 tries in rout of Worcester at Allianz Park in a week that saw Nigel Wray resign as chairman.

It was one-way traffic from the outset as Ben Earl opened the scoring after six minutes, with the first of Rotimi Segun's first-half double quickly following.

Brad Barritt and Mako Vunipola also went over before the break, and Sarries matched their haul from the first 40 minutes in the second period.

Richard Barrington, Maro Itoje, Duncan Taylor, Jackson Wray and, finally, in the 81st minute, Elliot Daly got on the scoresheet, with Owen Farrell nailing six conversion attempts.

There was a derby win for Gloucester as they put on a late show to beat Bath 29-15 at Kingsholm.

Rhys Priestland's five penalties had visitors Bath in front until just before the hour-mark, but tries from Gerbrandt Grobler and Ruan Ackermann in quick succession set up an ultimately comfortable victory.

Leicester got a much-needed win as they saw off Bristol Bears 31-18, led by England pair George Ford and Jonny May.

Tigers are only kept off the bottom of the table by Sarries, but a strong start set up a precious second victory of the season in the early kick-off.

Bristol-born Ellis Genge England prop went over with just three minutes played, and May and Ford crossed later in a first half that saw two Bears men sent to the sin bin.

Although Bristol battled back early in the second period, May had his second try with six minutes remaining, while Ford dispatched all four conversions and a penalty to leave Leicester 18 points better off than European Champions Sarries.

Leinster maintained their phenomenal 100 per cent Pro14 record by grinding out a 13-6 derby victory at Munster and Edinburgh beat Glasgow Warriors on Saturday.

The defending champions put on a defensive masterclass at Thomond Park to make it nine wins from nine in the competition.

Leinster held off a bright start from Munster to score through Ed Byrne from their first real attack of note.

Ross Byrne added the extras and split the posts again to make it 10-0 after 22 minutes, with JJ Hanrahan getting Munster on the board shortly before the break.

Hanrahan nailed another penalty early in the second half, but for all their endeavour, Munster could not find a way through a stoic Leinster defence.

Edinburgh - second in Conference B - overcame Glasgow 29-19 to keep alive their hopes of winning the 1872 Cup – contested annually between the Scottish rivals – for a third straight year, having lost to the same opponents a week ago.

Darcy Graham scored twice for Edinburgh, who were twice behind after the break due to tries from Scott Cummings and George Horne.

Benetton Treviso made it two wins over Italian rivals Zebre in the space of a week, hooker Hame Faiva scored a hat-trick in a 36-25 win despite the early sending off of Juan Ignacio Brex.

Louis Rees-Zammit scored a first Gloucester hat-trick but Northampton Saints ran out 33-26 winners in a seven-try thriller that sees them return to the top of the Premiership table.

In a match of high quality at Franklin's Gardens, it was fledging Welsh winger Rees-Zammit – who has five tries over his past two matches – who touched down first, racing free after picking up Mark Atkinson's grubber kick.

Saints took control through scores from Mike Haywood and Cobus Reinach and the respective boots of Dan Biggar and Piers Francis, before Chris Harris's converted try reduced the arrears.

Reinach's second, after a loose pass from Danny Cipriani, left Gloucester with an uphill task but Freddie Clarke released Rees-Zammit for his second of the match.

A yellow card for Josh Hohneck for a high tackle left Gloucester a man light, during which time Francis added three points from the tee and, although Rees-Zammit completed his treble when Gloucester worked the ball wide, he nailed another penalty to leave Saints out of sight.

Struggling Leicester Tigers dramatically fought back from a 14-point deficit to earn a thrilling 30-30 draw with Harlequins at Twickenham.

Quins were in complete command against a Leicester side with just a solitary win to their name this season, with tries from Paul Lasike, Marcus Smith and Chris Robshaw helping the hosts to a 27-13 lead.

But Jordan Taufua started the comeback on the hour, before Smith and Leicester fly-half George Ford exchanged penalties.

Will Collier's yellow then left Quins at a temporary numerical disadvantage, which Leicester made the most of when Telusa Veainu latched onto a kick from Ford, who added the extras to tie up the game.

Sale Sharks made it back-to-back wins to move seventh in the table as Rhys Priestland kicked 11 points in a 16-14 beating of Bath, for whom Akker van Der Merwe and Byron McGuigan went over in quickfire scores after the break.

Worcester Warriors, hammered 36-3 by Gloucester last time out, bounced back with a 20-6 beating of London Irish – the visitors having Motu Matu'u sent off seven minutes before the break, shortly after Allan Dell was also sin-binned for the away team. 

Saracens made it five Premiership victories on the bounce as they shrugged off conceding an early try to defeat Bristol Bears 47-13.

The defending champions – who still sit bottom thanks to their 35-point deduction for breaching salary cap rules – fell behind to Luke Morahan's ninth-minute try on Saturday.

But Saracens responded quickly through Mako Vunipola and swiftly wrested control thanks to Max Malins' try.

Malins helped himself to another after the restart, with Nick Tompkins also at the double as the home side went over five times in the second half.

However, Sarries are still 17 points behind Leicester Tigers, whose second-half capitulation at Welford Road enabled Exeter Chiefs to go top.

Exeter were 22-14 down at half-time, yet rallied after the interval to score 17 unanswered points and capitalise on Northampton Saints' 22-10 defeat at Sale Sharks.

Chris Ashton, Rohan Janse van Rensburg and Akker van der Merwe went over for Sale as the Sharks moved into the top four.

Meanwhile, Wasps suffered a third successive Premiership loss as they went down 28-22 at home to Harlequins, who held on for a bonus-point win despite having Joe Marler sin-binned late on.

Wasps took the lead at the Ricoh Arena, though Harlequins dominated for 40 minutes up to the hour mark, running in four tries without reply.

Thomas Young's effort eventually pulled the hosts back into contention, but the TMO denied them a late try and they were left with a losing bonus point as consolation.

A pair of tries from Matt Proctor helped Northampton Saints move top of the Premiership as they made it four wins from five with a 36-13 triumph over Leicester Tigers.

New Zealander Proctor, whose sole appearance for the All Blacks came a year ago, was making his Premiership debut and soon endeared himself to the Franklin's Garden crowd with an early brace in the derby.

Saints were without international trio Courtney Lawes, Dan Biggar and Owen Franks due to injury, yet they were 24-10 up at the interval, Proctor crossing twice and then producing the break that led to Api Ratuniyarawa going over.

There was no way back for Leicester, despite Guy Thompson's first-half score, as Tom Collins and Fraser Dingwall added further tries for Northampton after the interval.

Exeter Chiefs moved up to second, four points adrift of Saints, with a comfortable 38-3 success over Wasps.

Having lost to Bristol Bears last time out in the Premiership, Exeter bounced back in style in a five-try display, with England international Luke Cowan-Dickie among those to go over.

Fourteen-man Sale Sharks were beaten 20-13 by Worcester Warriors as the visitors were left to rue Jean-Luc du Preez's red card for a shoulder-led tackle on the stroke of half-time.

Sale led at the break, Faf de Klerk and Chris Ashton having gone over, but Perry Humphreys and Ashley Beck both crossed in the space of two minutes after the Sharks went down to 14 men, with the boot of Duncan Weir - who kicked two conversions and a pair of penalties - proving pivotal.

Bristol Bears pulled off a stunning fightback to beat Exeter Chiefs 20-17 and go top of the Premiership, while Waisake Naholo scored a debut try in London Irish's thrashing of bottom side Leicester Tigers on Sunday.

The Chiefs looked to be cruising to victory when they scored 17 unanswered points in the first half of a Sandy Park thriller.

Bristol had other ideas and snatched an unlikely win right at the end when Dan Thomas crashed over with Exeter unable to stop a driving maul.

Tries from Sam Simmonds and Nic White along with seven points from the boot of Joe Simmonds put Exeter in command at the interval, but Bristol scored 17 points in the last 20 minutes to stun Rob Baxter's side.

Callum Sheedy was on target with two penalties and Piers O'Conor dotted down with White in the sin bin before Thomas was awarded a decisive score following consultation with the TMO.

Sheedy added the extras as Bristol moved level with Northampton Saints on 14 points and replaced them at the summit.

Former New Zealand wing Naholo, one of a host of high-profile signings for the Exiles following their promotion from the Championship, was among five try-scorers in a bonus-point victory at the Madejski Stadium.

Nick Phipps picked out fellow debutant Naholo with a brilliant cross-field kick and the powerful flyer finished clinically, while Ruan Botha was another new recruit to touch down to keep the Tigers at the foot of the table.

Manu Vunipola kicked a last-gasp penalty to secure a dramatic 16-13 win for Saracens over London Irish at Allianz Park in the Premiership on Saturday.

On a day when cousins Billy and Mako suffered Rugby World Cup final heartache with England, Vunipola was the hero for the reigning champions – but only after he flirted with playing the role of villain.

Mark McCall's side were 8-6 ahead at the break, Alex Lozowski's penalty and a try from Titi Lamositele coming between a pair of three-pointers from the boot of Stephen Myler.

Irish initially turned the tables after the break as Albert Tuisue dotted down at the end of a driving maul and Myler added the extras. 

But, with time running out, Ben Earl forced his way over to tie it up and, though Vunipola was wayward with a twice-taken conversion, he split the posts with a penalty that proved to be the last action of the game.

In the other two games, both Leicester Tigers and Wasps picked up their first wins of the season.

The Tigers dished out a first defeat of the campaign to Gloucester, triumphing 16-13, while Wasps overcame Bath 30-22.

Ben Earl scored a second-half double as Saracens responded to their opening-day defeat with a 24-10 Premiership win at Leicester Tigers on Sunday.

Sarries started the defence of their title by losing at home to Northampton Saints last weekend, but they tamed the Tigers at Welford Road.

The Premiership and European champions were without Ben Spencer after the scrum-half was called up to the England squad ahead of the Rugby World Cup final as a replacement for the injured Willi Heinz.

The London club also lost full-back Alex Goode for up to four months with a pectoral tear this week but showed their strength in depth by outscoring Leicester by three tries to one.

Nick Tompkins rounded off a well-worked move to score the only try of a first half that ended with Mark McCall's men leading 10-3 and Earl ran 30 metres to go under the posts seven minutes after the interval.

Adam Thompstone's intercept try midway through the second half reduced the deficit to seven points, but Earl grabbed his second late on to seal it for Sarries.

James Grayson's late penalty snatched a 27-25 win for Northampton Saints at champions Saracens as Exeter Chiefs started the Premiership season with a narrow win over Harlequins.

Saints led 21-16 at half-time following tries from David Ribbans, Rory Hutchinson and Henry Taylor.

The European Champions Cup holders looked set to edge it when Ben Spencer slotted over his sixth penalty of the match with four minutes remaining, but there was a final twist to the tale.

Grayson stepped up for a shot at goal in the closing stages and made no mistake, sealing Northampton's first away win over Saracens in three years.

Exeter, runners-up last season, got their league campaign under way with a 22-19 success over Quins at Sandy Park.

Jonny Hill scored the Chiefs' only try in the first half and Joe Simmonds booted 17 points as Gabriel Ibitoye's double proved to be in vain.

Worcester Warriors were 24-16 winners over Leicester Tigers, while Gloucester came out on top 18-16 at Sale Sharks.

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