Flamengo and Boca Juniors reached the Copa Libertadores semi-finals as Internacional and LDU Quito bowed out on Wednesday.

Gabriel 'Gabigol' Barbosa scored to earn Flamengo a 1-1 draw away to Brazilian rivals Internacional and a 3-1 victory on aggregate.

Flamengo – led by Jorge Jesus and boasting former Atletico Madrid star Filipe Luis – carried a 2-0 lead into the return leg in Porto Alegre.

Internacional gave themselves hope just past the hour-mark when Rodrigo Lindoso glanced a header beyond Flamengo goalkeeper Diego Alves.

Gabigol – tipped to make his loan deal from Serie A giants Inter permanent – extinguished Internacional's chances with five minutes remaining after side-footing into an empty net, having received a simple pass from first-leg hero Bruno Henrique.

Flamengo, who claimed their one and only Libertadores title in 1981, will meet Gremio in the final four as they return to the semis for the first time in 35 years.

Meanwhile, Boca reached the semi-finals for the second successive year following their 0-0 draw at home to Antonio Valencia's LDU Quito midweek.

There were no goals scored in Buenos Aires but Boca still progressed 3-0 on aggregate after their comprehensive victory last week.

Daniele De Rossi came off the bench with 10 minutes remaining as six-time champions and last season's runners-up Boca await holders River Plate or Cerro Porteno in the semis.

Boca Juniors took a giant step towards the Copa Libertadores semi-finals, while Flamengo beat Internacional on Wednesday.

Runners-up last year, Boca comfortably beat a 10-man LDU Quito 3-0 in the first leg of their quarter-final in Ecuador.

Boca, with Daniele De Rossi watching from the bench, opened the scoring in the 11th minute, Ramon Abila getting on the end of an Alexis Mac Allister pass to make it 1-0.

LDU Quito were dealt a huge blow just before half-time as Jefferson Orejuela was sent off for a rash challenge.

Emanuel Reynoso doubled Boca's lead with a brilliant 25-yard free-kick, and Kevin Minda was sent off while on the bench for the hosts.

Boca sealed a fine win with nine minutes remaining, Luis Caicedo's poor defending eventually leading to the defender scoring an own goal.

If Boca and rivals River Plate, who play Cerro Porteno on Thursday, advance, they will meet in the semi-finals in a rematch of last year's controversial decider.

In the day's other game, Bruno Henrique's late brace saw Flamengo beat Internacional 2-0 at the Maracana.

Henrique tapped in a Gerson pass for the 75th-minute opener before producing a fine finish soon after to seal Flamengo's first-leg victory.

River Plate survived a scare to reach the Copa Libertadores quarter-finals, while Palmeiras also moved through on Tuesday.

Defending champions River needed penalties to overcome Cruzeiro after their round-of-16 tie finished locked at 0-0.

Franco Armani was the hero for River, saving penalties from Henrique and David in the shoot-out in Belo Horizonte.

The goalkeeper stepped up as the Argentine giants claimed a 4-2 shoot-out victory, moving into a last-eight tie against either San Lorenzo or Cerro Porteno.

In Sao Paulo, Palmeiras left it until the second half to claim a 4-0 win over Godoy Cruz, progressing 6-2 on aggregate.

The Brazilians needed a Raphael Veiga penalty to break the deadlock before further goals from Miguel Borja, Gustavo Scarpa and Dudu.

Godoy Cruz were reduced to 10 men when 18-year-old midfielder Agustin Manzur was sent off for a dreadful challenge in the 88th minute.

In Paraguay, Olimpia could only play out a 1-1 draw with LDU Quito, the result enough for the Ecuadorians to advance 4-2 on aggregate.

LDU Quito received two red cards, with goalscorer Jhojan Julio and unused substitute Edison Realpe sent off.

Palmeiras came from behind to salvage a draw with Godoy Cruz in the first leg of their Copa Libertadores last-16 tie, while River Plate were held on Tuesday.

Trailing to a Santiago Garcia brace, Palmeiras rallied to secure a 2-2 draw in Mendoza.

Garcia headed in the opener from close range in the sixth minute before doubling the lead just before the half-hour mark.

However, Felipe Melo brought Palmeiras back into the encounter with a 34th-minute header.

Incredibly, Garcia had a chance to complete his hat-trick before half-time, but the forward had a penalty saved by Palmeiras goalkeeper Weverton.

The hosts were punished for that miss just before the hour-mark, Miguel Borja taking a Luan pass before a brilliant turn and finish, putting the Brazilians in a decent position ahead of next week's second leg.

River Plate, defending their title, could be left to rue a late penalty miss after drawing 0-0 at home to Cruzeiro.

Awarded a spot-kick following a VAR review, River – who had the better of the chances throughout – saw Matias Suarez blaze the 99th-minute penalty over the crossbar.

In the day's other game, LDU Quito took a step towards the quarter-finals with a 3-1 win at home to Olimpia.

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