Holger Rune upset world number one Novak Djokovic to reach the semi-finals of the Italian Open.

The 20-year-old Dane came through 6-2 4-6 6-2 against the defending champion in a rain-hit encounter in Rome.

Seventh seed Rune raced through the opening set in 39 minutes before Djokovic was seen to by the physio early in the second and given some medication before the weather forced play to be suspended.

Top seed Djokovic – who beat Britain’s Cameron Norrie in a feisty fourth-round match – levelled the match soon after the resumption, but it was Rune who pulled clear in the decider.

Rune, making his tournament debut, opened a 4-0 lead after a double break before closing out the match for successive victories in his matches against the Serbian.

“It’s really a big win for me,” Rune said in his on-court interview.

“Obviously I did it last year in Paris as well, but every match is a huge challenge for me when I play against Novak.

“He is one of the greatest that’s ever played the game. I knew I had to be at my best and I said it yesterday, and I was today.

“I am super proud of myself and I enjoyed every moment out there, but I stay humble of course. I have a lot to achieve.”

Cameron Norrie set up a last-16 clash with Novak Djokovic at the Italian Open thanks to a 6-2 7-6 (4) victory over Marton Fucsovics.

The British number one had looked on track for a straightforward triumph as he won the first set with minimal fuss and then stormed into a 5-1 lead in the second, only for his Hungarian opponent to fight back to 5-5.

Norrie edged the tie-break which followed, 7-4, however, and will next face Djokovic after the world number one continued his winning run by overcoming Grigor Dimitrov 6-3 4-6 6-1.

The Serbian was given a tough test by the Bulgarian, who – having been 3-1 down in the second set – broke twice to force the decider, but the top seed and defending champion rallied to see out the match convincingly.

“(I was) very solid. I think I could have won in straight sets,” 22-time grand slam winner Djokovic told the ATP website.

“I was a set and 4-2 up and had a pretty decent forehand in the middle of the court at deuce on his serve and missed that.

“He held his serve well, we had new balls the next game, I did a double fault, the crowd got into it and got behind him and of course the energy of the place and of the match changed.

“I dropped my level a bit, but luckily I managed find it right away in the first game (of the third set), made that crucial break and kind of shifted the momentum to my side, so I’m really pleased with the way I closed out the match.”

Russian world number three Daniil Medvedev earned his maiden win at the tournament with a 6-4 6-2 triumph over Finland’s Emil Ruusuvuori and expressed his relief at finally winning a match in Rome.

“We can talk about all of the matches I lost here, they were different,” Medvedev told the ATP website after reaching the third round.

“The first one, I feel like I should have won, but it is (what it is). Whenever I come to a tournament, I know that I can play well, so I’m happy to finally get the win here in Rome.”

Denmark’s Holger Rune continued his good run with a 6-4 6-2 success against Andy Murray’s conqueror Fabio Fognini, while Norway’s world number four Casper Ruud defeated Alexander Bublik 6-1 4-6 7-6 (0).

In the women’s event, defending champion Iga Swiatek eased into the last 16 with a comfortable victory over Lesia Tsurenko.

The world number one continued her strong start in the tournament, cruising to a 6-2 6-0 success, and was pleased with another solid performance.

“For sure, after a pretty rusty start, I was able to break back pretty quickly, so I’m happy that I played solid game,” she said in her post-match press conference.

“Just to have another experience playing on centre court… and I’m happy that it wasn’t raining!”

Czechia’s Marie Bouzkova’s upset Coco Gauff in their last-32 encounter, prevailing 4-6 6-2 6-2 to oust the American sixth seed, while Madison Keys advanced to the last 16 via walkover after her opponent Victoria Azarenka withdrew due to a leg injury.

Andy Murray was beaten by fellow veteran Fabio Fognini to suffer a disappointing first-round exit at the Italian Open.

Murray, fresh from claiming success at an ATP Challenger event in Aix-en-Provence on Sunday, had hoped to extend his five-match winning streak but instead saw his time in Rome end early to the 35-year-old home favourite.

A 6-4 4-6 6-4 defeat to the world number 130 halts the momentum of the Briton, who will now turn his attention to the French Open later this month.

Three-time grand slam winner Murray made the worst possible start in Italy with Fognini able to break him in his opening service game.

While the Scot did force a number of opportunities to break back at 3-2, he failed to seize the moment and his frustration boiled over later in the set with a debate occurring with umpire Mohamed Lahyani over a tight line call that saw Fognini go 5-3 up.

Fognini went on to clinch a 69-minute opener but quickly found himself 4-0 down in the second with Murray hitting his straps, albeit helped by a string of double-faults from his opponent.

A second-set wobble saw the veterans exchange breaks before Murray did force a decider with the encounter by that point edging past the two-hour mark.

Despite Fognini seemingly struggling physically during the second set, he found a new lease of life and took the initiative with an early break in the third.

Murray tried to keep pace with the Italian, who was mixing an array of baseline winners with unforced errors but a concern for the two-time Wimbledon winner occurred when he held his back during the seventh game of the third.

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It was not enough to stop the new world number 42 from continuing, and yet there would be no big fightback on this occasion with Fognini earning a fifth victory in nine meetings thanks to an ace after two hours and 55 minutes.

This latest first-round exit at an ATP 1000 event on clay, after similar losses in Madrid and Monto-Carlo, will give Murray around 10 days preparation before Roland Garros begins on May 22 where he is now unlikely to be seeded.

Elsewhere, fellow Briton Kyle Edmund was also knocked out in the Italian Open first round after he suffered a 6-1 6-3 defeat to Alexandre Muller.

World number 473 Edmund saw his struggles continue against a French player who broke into the top 100 last month.

Muller managed to wrap up the first set in 23 minutes in Rome and, while Edmund was able to push his opponent more in the second, the former Australian Open semi-finalist was consigned to a third consecutive loss.

Robert MacIntyre landed his second DP World Tour title by beating Matt Fitzpatrick in a play-off finish to the Italian Open.

The 26-year-old, whose only previous Tour triumph came at the Cyprus Showdown in 2020, started the final round three shots behind overnight leader Fitzpatrick.

However, a remarkable 10 birdies for MacIntyre at Marco Simone Golf and Country Club saw him finish seven-under par on Sunday and 14-under overall, level with Fitzpatrick.

US Open winner Fitzpatrick, who was seeking a second title of the season, birdied the 18th hole to force a play-off in Rome.

Just one hole was required as the Englishman could only manage a par after a poor tee shot, whereas MacIntyre birdied to seal a surprise victory.

"This means everything," MacIntyre said. "I was down and out about two or three months ago – I didn't know what I was doing and didn't know where to go.

"But we spoke to the right people and I started working with Simon Shanks. I mean, I've hit two perfect golf shots into the last there. There's so much hard work gone into this."

Rory McIlroy had been expected to rival Fitzpatrick for the title, the Northern Irishman starting the day one shot behind, but he ended up finishing fourth.

He started the final round with a double-bogey on the first hole, before recovering with five birdies over the next 14 holes.

McIlroy was back within one shot of the lead at that point, but a bogey on the par-four 16th, when finding the water off the tee, effectively ended his chances.

Victor Perez capitalised to finish third at 13 under, with his final round of 66 bettered only by MacIntyre's 64.

Matt Fitzpatrick is "not really too bothered" about the prospect of playing alongside LIV Golf rebels in Europe's Ryder Cup team.

Debate around the controversial Saudi-backed breakaway series has dominated this year and is only likely to ramp up further ahead of the Ryder Cup in 2023.

Rory McIlroy has been a fierce opponent of LIV Golf, and speaking on Wednesday, ahead of the Italian Open, he reiterated his stance on selection for the prestigious team event.

"If I have said it once, I've said it a hundred times: I don't think any of those guys should be on the Ryder Cup team," he said.

However, U.S. Open champion Fitzpatrick, McIlroy's European team-mate, does not agree.

McIlroy is set to play the Ryder Cup for the seventh time and already has four triumphs to his name. On the other hand, Fitzpatrick has only been on the losing team, in both 2016 and 2021. 

"I just want to win the Ryder Cup," Fitzpatrick said. "I want to be part of the team myself, but I want the 11 best guys we can get.

"I'm not really too bothered about where they are going to come from. I just want to make sure that we win, and I think that's what's most important.

"I know other guys might not necessarily agree with that, but I know the winning feeling is worth more than any sort of arguments you might have with other players.

"There's one that I had a conversation with last week – I told him I'd happily have him on the team. I'd have no issues."

Bernd Wiesberger, Paul Casey, Lee Westwood, Sergio Garcia and Ian Poulter were all team-mates of McIlroy and Fitzpatrick in Europe's 2021 team and have each since played LIV Golf events.

Rory McIlroy will get some early Ryder Cup preparation when he makes his Italian Open debut next month.

Just under a year before Europe attempt to wrestle the Ryder Cup back off the United States, McIlroy will get a first look at the Marco Simone Golf and Country Club venue where the biennial event will be staged.

McIlroy is riding on the crest of a wave after becoming the first player to win the FedExCup three times in dramatic fashion at East Lake.

The four-time major champion trailed Scottie Scheffler by six shots during his final round of the Tour Championship on Sunday, but a closing 66 sealed a hat-trick of FedExCup victories – and a whopping $18million in prize money.

DP World Tour Rankings leader McIlroy will be on his way to the outskirts of Rome eyeing another title in a tournament that starts on September 15.

The Northern Irishman said: "Not only is the city of Rome steeped in history but so too is their national open, so I am really looking forward to the Italian Open this year.

"It's the first time I have played in Italy, and I've heard the Italian fans are very passionate, so I'm excited to get out there and experience a new challenge."

McIlroy is third in the world rankings behind Scheffler and Cameron Smith.

Iga Swiatek continued her remarkable winning run to reach the Internazionali d'Italia final as she defeated Aryna Sabalenka 6-2 6-1.

Top seed Swiatek extended to 26 matches unbeaten, dating back to mid-February, with victory over Bianca Andreescu to set up the last-four meeting with Sabalenka, who battled past Amanda Anisimova.

The pair exchanged opening breaks in a tentative start to the clash in the Italian capital before Sabalenka again failed to hold her serve as Pole Swiatek took an early 3-1 lead.

World number eight Sabalenka, the third seed in the tournament, offered little response as the in-form Swiatek then claimed the first set with ease.

Sabalenka was again caught cold and had no answer as world number one Swiatek raced out the blocks in the second set, breaking twice via marathon rallies, to gain a 4-0 lead.

Swiatek swiftly wrapped victory up, despite a short medical time out for her opponent, and has now won all three of her WTA Tour encounters with Sabalenka in 2022, conceding just 12 games in the process.

Meanwhile, in the last 25 years only Serena Williams in 2013, Kim Clijsters in 2003 and Martina Hingis in 1998 have reached the final in Rome with fewer games dropped than Iga Swiatek this season (17).

The 20-year-old Swiatek continues on her quest for a fourth straight WTA 1000 crown and fifth consecutive title and in the final will face either Ons Jabeur or Daria Kasatkina, who face off later on Saturday.

Rafael Nadal conceded Spanish tennis fans have a new star to support after Carlos Alcaraz continued his remarkable season with success at the Madrid Open.

Alcaraz breezed past Alexander Zverev in just 62 minutes in the Madrid final on Sunday as he became the second-youngest player to win two ATP Masters 1000 titles, after also triumphing in Miami in March.

The 19-year-old is also the youngest five-time ATP Tour winner since Nadal won seven titles by the same age in 2004-05.

Alcaraz had already made more history en route to the final in the Spanish capital as he achieved a new feat, becoming the first player to defeat Nadal and Novak Djokovic in consecutive matches.

Record 21-time grand slam winner Nadal acknowledged that Alcaraz's meteoric rise to success has caused somewhat of a changing of the guard within Spanish tennis.

"First, I think he is young, he is new and all the new things are much more interesting than older things. Without a doubt, when you see a new car, it always looks better," Nadal told reporters.

"When you see a new phone, they always look better than the old ones. It's something that is normal in this life. I can't complain at all about that.

"At the same time, I am happy to have somebody like him from my country achieving all the things that he is achieving."

Alcaraz opted to sit out of the Internazionali d'Italia this week to recover from an ankle injury, with the upcoming French Open at Roland Garros his next target for more success.

Nadal has had his injury problems as well, only recently returning from a rib injury that kept him sidelined for six weeks, while he continues to struggle with foot issues.

"Of course, at my age, when you start having more problems than what you can manage, of course it is tough," 35-year-old Nadal added. 

"Body issues, pains, you can manage that. The problem is when you start to feel that with all the things that are going through your body, you can't be competitive enough to fight for the things that really keep exciting you."

For now, though, Nadal remains content with how he is competing as he seeks improvements in Rome, where he faces either John Isner or Francisco Cerundolo in his opening match.

"I like what I do, honestly. I am not playing anymore for things outside of my happiness and for things outside of my personal motivation," he continued.

"For the moment I am happy. It is true that I went through, again, a tough period of time. But I am here to enjoy and to give myself a chance to play well here in Rome.

"I need to keep improving. In terms of movement, in terms of being more fitter, in terms of reading again the game. In general terms, [it was] not a negative week in Madrid, even if the tournament is probably the most difficult for me."

Emma Raducanu is "managing" a back problem ahead of her first-round Internazionali d'Italia clash with Bianca Andreescu.

The reigning US Open champion exited the Madrid Open at the last-16 stage, going down in three sets to Anhelina Kalinina after struggling with an injury which she admitted had been "taking its toll".

Raducanu said in the aftermath of that 6-2 2-6 6-4 defeat that she would only have given herself a "five per cent chance" of advancing after suffering the injury, and expressed doubt over her ability to compete in Rome.

However, the 19-year-old now insists she will be able to cope on the clay in Italy, saying she needs to adapt to the intensity of top-level matches after suffering from several injury problems this year.

"I think it's just coming from a lot of intensity and overload" Raducanu said. "My back, I'm managing it.

"It's fine. But it's just trying to adapt again to the long matches, to the intensity. I think that all of the small sort of niggles I'm getting, they're all related and connected to each other, when something is overcompensating perhaps."

Raducanu's first assignment in Rome will see her face Canadian Andreescu, who also won the US Open as a teenager when she shocked Serena Williams with a straight-sets final victory in 2019.

That contest will mark the first head-to-head meeting between the two players, and Raducanu was looking forward to facing the former world number four as she highlighted the contrast between conditions in Rome and Madrid.

"Of course, we are both pretty good players," Raducanu said. "It's going to be a good match-up. She's a great athlete and obviously a champion. She's got a really good attitude. I think it's going to be interesting.

"I think here is completely opposite [to Madrid]. It's quite heavy and slow, so there's going to be a lot longer points. It will be interesting to see what the differences are. But I can already feel them on the court tennis-wise."

Matteo Berrettini could miss the French Open after the world number six was forced to withdraw from three tournaments as he continues to recover from minor hand surgery.

The Italian progressed to the Wimbledon final in 2021 and started the new season in encouraging fashion as he reached the Australian Open semi-finals, where he was well-beaten by eventual winner Rafael Nadal.

However, the 25-year-old has seemingly struggled from then on, with his next best performance coming in Rio – where he made the last eight – as he limped to a 9-6 record so far in 2022.

Further difficulties followed for Berrettini after he sustained an injury to his right hand late in March, forcing him to withdraw from the Miami Open before undergoing a "minor operation".

Berrettini provided another update on Instagram on Thursday, revealing he would not feature at the Monte-Carlo Masters, scheduled to start later this week, or the Madrid Open and Italian Open at the start of May.

The latter tournament in Rome begins just two weeks before the second grand slam of the year, leading to concerns that Berrettini may not feature at Roland Garros.

"UPDATE – following advice from the medical experts, my team and I have decided that it is crucial I do not put time pressure on my recovery process," he posted.

"We have therefore decided I should withdraw from the Monte-Carlo, Madrid and Rome tournaments to ensure I give myself the proper amount of time to return at my highest level.

"Withdrawing from these events, particularly Rome, was an extremely tough decision, however it is the right one to ensure many more years of competing at the highest level for the biggest trophies.

"Thanks very much for all the support. My recovery process is on track and I look forward to seeing you on-court soon."