Four-time Brazilian champions Cruzeiro have been relegated from the top flight for the first time in their 98-year history.

Cruzeiro have endured a torrid campaign and needed to beat Palmeiras on the final day of the Brasileirao season and hope Ceara fell to defeat at Botafogo, but neither result went their way.

Ze Rafael and Dudu scored for Palmeiras as they won 2-0 in Belo Horizonte, while Thiago Galhardo's penalty cancelled out Marcos Vinicius' opener to earn Ceara a 1-1 draw.

The referee ordered both sets off players off the field late on in Cruzeiro's clash due to unsavoury scenes in the Mineirao stands, with supporters ripping out seats and setting off smoke bombs in protest at their team's plight.

Cruzeiro, who won the Copa Libertadores in 1976 and 1997 and were Brazilian champions as recently as 2014, lost their last five games of the campaign to finish 17th, three points behind Ceara.

River Plate survived a scare to reach the Copa Libertadores quarter-finals, while Palmeiras also moved through on Tuesday.

Defending champions River needed penalties to overcome Cruzeiro after their round-of-16 tie finished locked at 0-0.

Franco Armani was the hero for River, saving penalties from Henrique and David in the shoot-out in Belo Horizonte.

The goalkeeper stepped up as the Argentine giants claimed a 4-2 shoot-out victory, moving into a last-eight tie against either San Lorenzo or Cerro Porteno.

In Sao Paulo, Palmeiras left it until the second half to claim a 4-0 win over Godoy Cruz, progressing 6-2 on aggregate.

The Brazilians needed a Raphael Veiga penalty to break the deadlock before further goals from Miguel Borja, Gustavo Scarpa and Dudu.

Godoy Cruz were reduced to 10 men when 18-year-old midfielder Agustin Manzur was sent off for a dreadful challenge in the 88th minute.

In Paraguay, Olimpia could only play out a 1-1 draw with LDU Quito, the result enough for the Ecuadorians to advance 4-2 on aggregate.

LDU Quito received two red cards, with goalscorer Jhojan Julio and unused substitute Edison Realpe sent off.

Palmeiras came from behind to salvage a draw with Godoy Cruz in the first leg of their Copa Libertadores last-16 tie, while River Plate were held on Tuesday.

Trailing to a Santiago Garcia brace, Palmeiras rallied to secure a 2-2 draw in Mendoza.

Garcia headed in the opener from close range in the sixth minute before doubling the lead just before the half-hour mark.

However, Felipe Melo brought Palmeiras back into the encounter with a 34th-minute header.

Incredibly, Garcia had a chance to complete his hat-trick before half-time, but the forward had a penalty saved by Palmeiras goalkeeper Weverton.

The hosts were punished for that miss just before the hour-mark, Miguel Borja taking a Luan pass before a brilliant turn and finish, putting the Brazilians in a decent position ahead of next week's second leg.

River Plate, defending their title, could be left to rue a late penalty miss after drawing 0-0 at home to Cruzeiro.

Awarded a spot-kick following a VAR review, River – who had the better of the chances throughout – saw Matias Suarez blaze the 99th-minute penalty over the crossbar.

In the day's other game, LDU Quito took a step towards the quarter-finals with a 3-1 win at home to Olimpia.

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