The first week of the 2022 NFL season is here, with all the possibilities a new campaign brings.

Things kicked off on Thursday with the Buffalo Bills beating the Los Angeles Rams 31-10 thanks to a starring role from quarterback Josh Allen, who threw three touchdowns against the defending champions.

There are even more enticing games to look forward to over the weekend, with last season's Super Bowl runners up the Cincinnati Bengals hosting the Pittsburgh Steelers, Patrick Mahomes and the much-fancied Kansas City Chiefs facing Kyler Murray and the Arizona Cardinals, and it will be Aaron Rodgers v Kirk Cousins as the Green Bay Packers go to the Minnesota Vikings.

Stats Perform dives head first into Opta data to preview those games and more of the opening weekend of NFL action.

Pittsburgh Steelers @ Cincinnati Bengals

The Bengals have won their last three games against the Steelers (27-17 in December 2020, 24-10 and 41-10 last season). It is the Bengals' longest winning streak versus the Steelers since they won six consecutive games from 1988 through 1990.

Mitch Trubisky will be the first quarterback other than Ben Roethlisberger to start a season opener for the Steelers since Dennis Dixon in 2010 (Roethlisberger was suspended). Trubisky is 1-2 in season openers, losing to the Packers twice and beating the Detroit Lions (all when he was with the Chicago Bears).

The Bengals played a league-high seven games decided by exactly three points during the 2021 regular season (won three, lost four), the highest single-season total by an NFL team since the 2012 Steelers (seven). Three of Cincinnati's four postseason games were also decided by exactly three points, including the 23-20 Super Bowl loss to the Rams.

Bengals quarterback Joe Burrow completed 67 of 85 passes for 971 yards, eight touchdowns and no interceptions over his final two games in the 2021 regular season (Week 16 against the Ravens, Week 17 against the Chiefs). Burrow's passing yardage is the second-highest two-game total by one player in NFL history, trailing only Dak Prescott's 974 passing yards over a two-game span in 2020.

Kansas City Chiefs @ Arizona Cardinals

The Chiefs have won their division in six consecutive seasons, which is three more than the next longest active streak (Green Bay). Only two teams in NFL history have had longer streaks (New England - 11, 2009-2019 and LA Rams - seven, 1973-1979).

Patrick Mahomes has won 50 of his 63 career starts as Kansas City's quarterback. The only QB in the Super Bowl era to reach 50 wins in fewer career starts than Mahomes was Kenny Stabler, who earned his 50th win in his 62nd start.

Arizona scored 30 or more points in nine different games in 2022, tied for the most in a single season in team history. Since a 56-14 win over the Vikings in Week 4 of 1963, the Cardinals have gone 903 games without scoring 50 points, which is the longest streak in NFL history (Broncos, 761 straight games from 1963-2013).

Cardinals QB Kyler Murray will not want to be upstaged by Mahomes, and is the only player in NFL history to have at least 70 passing touchdowns and 20 rushing touchdowns in the first three seasons of his NFL career.

Green Bay Packers @ Minnesota Vikings

In their 22 road games against the Vikings this century, Green Bay has scored 30 or more points in 10 of them. That is tied for most 30-point games by an NFL team at a single opponent in that time with the Patriots at the Bills.

No NFL head coach has won more games over his first three NFL seasons than Matt LaFleur (39; George Seifert had 38). A win Sunday would make LaFleur the third coach in NFL history with 40 wins through 50 career games as head coach, joining Paul Brown (41) and Chuck Knox (40).

Kirk Cousins has thrown for at least 3500 yards and 25 TDs in seven consecutive seasons, the longest active streak in the NFL. He is the fifth QB in NFL history to have more than five straight, joining Peyton Manning, Drew Brees, Philip Rivers and Tom Brady.

Since becoming Green Bay's starter in 2008, Aaron Rodgers has thrown 169 TDs against division opponents, compared to 25 interceptions. The Vikings have a total of 121 passing touchdowns and 73 interceptions against the NFC North in that span.

Elsewhere...

When Carolina host Cleveland, with Baker Mayfield starting for the Panthers and Myles Garrett starting for the Browns, they will become the second pair of number one overall draft picks for the same team to go on to play against one another. The others were Jeff George and Steve Emtman in 1995.

The Eagles head to the Lions, with no team targeting their receivers less frequently than Philadelphia last season (239 targets), which led to the acquisition of A.J. Brown. The fourth-year WR has scored a TD on 13.0 percent of his career catches, third-highest rate among active players (min. 150 receptions).

The New Orleans Saints will need to beware of Foye Oluokun, who led the NFL last season with 192 total tackles, becoming the first Atlanta Falcon to lead the league in that category since Jessie Tuggle in 1995 (152). Oluokun's 192 total tackles were the most in a season by an NFL player since Chris Spielman had 195 in 1994 for the Lions.

Tom Brady is back for Tampa Bay Buccaneers after a very brief retirement as they travel to the Dallas Cowboys. The 45-year-old's last two seasons mark the first time in NFL history a QB has had 40 or more TD passes and a passer rating of 100.0 or better in back-to-back seasons.

Los Angeles Rams coach Sean McVay admitted it was a "humbling experience" to lose 31-10 to the Buffalo Bills in the opening game of the new NFL season.

The Bills looked strong throughout at SoFi Stadium, with quarterback Josh Allen putting in a sensational performance as he threw three touchdowns, rushed for one of his own, and completed 26 of 31 passes for a total of 297 yards.

After unveiling their Super Bowl LVI banner, the Rams struggled in front of their own fans as all 10 of their points came in the second quarter, with Buffalo shutting them out in the second half.

"When you look at a lot of the ways that this game unfolded, [I] feel a huge sense of responsibility to this team," McVay said after the loss.

"We weren't ready to go. I take a lot of pride in that, and that's on me. I've got to do better. There were a lot of decisions that I made that I felt didn't put our players in good enough spots.

"So it was a humbling experience, but we're going to stay connected. We're going to all look inward. We're going to do a better job moving forward."

Allen became the first QB in NFL history to record 250+ passing yards, 50+ rushing yards, three or more passing TDs, a rushing TD, 80 per cent completions and a win in the same game.

Speaking to NBC after the victory, Allen said: "We knew if we came out and tried to execute the way we know we can execute, we were going to move the ball the ball and score. Our defense played a hell of a game.

"Defense's job is to get the ball back, but the offense can help and let them go and pin their ears back by getting up and putting them in legit passing situations and letting them go. 

"We got a bunch of dawgs up front. [Former Ram Von Miller] is the leader of that D-line and they played outstanding."

The Bills play the Tennessee Titans at Highmark Stadium in Week 2, while the Rams will look to put their opening defeat behind them as they host the Atlanta Falcons.

The Buffalo Bills were too strong for the reigning Super Bowl champions in the NFL's season kickoff on Thursday night, shutting the Los Angeles Rams down in the second half to run away 31-10 winners on the road.

It was a stylish start for the Bills as they received the opening kick and marched down the field in nine plays, culminating in a 26-yard touchdown pass from Josh Allen to Gabriel Davis for the first score of the season.

That set the table for what looked like it may be a shootout, but the rust was still clearly not shaken off as the next five combined possessions resulted in three turnovers and two punts.

A beautiful throw from Matthew Stafford found Cooper Kupp in the back corner of the endzone late in the second quarter, and after Allen's second interception of the game, a 57-yard field goal as time expired from Matt Gay had things tied at 10-10 going into halftime.

There were warning signs for the Rams as they needed three Bills turnovers to remain competitive, and when the visitors cleaned things up in the second half, the hosts had no answer.

The first three Bills drives of the second half all resulted in touchdowns, with Allen rushing for one score, finding Isaiah McKenzie for a short-range touchdown, and heaving long for a 53-yarder to Stefon Diggs to complete the rout.

Stafford could only find success throwing to star receiver Cooper Kupp, who finished with 13 catches for 128 yards and a touchdown from his 15 targets, while the five other players to catch a pass combined for 16 catches for 112 yards on 25 targets. He also had three interceptions after one more in garbage time.

Allen finished 26-of-31 for 297 yards with three touchdowns and two picks, adding 10 rushes for 56 yards and a score on the ground. Diggs was his top receiver with eight catches for 122 yards and a touchdown from nine targets.

The NFL is set to hold a moment of silence ahead of Thursday's season-opening kick-off encounter between the Buffalo Bills and the Los Angeles Rams following the death of HRH Queen Elizabeth II.

The reigning Super Bowl champions will make the trip to New York state to start their defence in the 2022 campaign curtain raiser.

Before a ball is kicked however, both teams will pay tribute to the late monarch, Britain's longest-reigning sovereign at the time of her passing at the age of 96.

"Everyone at NFL UK is deeply saddened to hear of the passing of Her Majesty The Queen, Elizabeth II," read an official message posted to social media by the league.

"Our thoughts and deepest sympathies are with The Royal Family. We join all those mourning the loss of Her Majesty."

The NFL is due to hold three games in London this year as part of their International Series, with the first to come in week four between the Minnesota Vikings and the New Orleans Saints at Tottenham Hotspur Stadium.

Over seven decades on the throne, the Queen oversaw a number of major events – not least in the sporting world.

Sport was a significant feature of Her Majesty's 70-year reign, from attending events to handing over trophies, most famously in 1966 when England lifted the World Cup at Wembley.

Following the announcement of her passing on Thursday, Stats Perform looks at the major sporting events that coincided with prominent milestones throughout the Queen's reign.

 

The Queen's Coronation, 1953

Princess Elizabeth was officially crowned Queen on June 2, 1953, a year after the death of her father George VI. Aged just 25, her ascension to the throne took place amid a glittering ceremony at Westminster Abbey. In the sporting world, Alberto Ascari won the Formula One championship for a second successive year shortly after the historic moment. He remains one of only two Ferrari drivers to have won multiple titles, along with the great Michael Schumacher, while no Italian has triumphed since. This was also the year Ken Rosewall, one of the greatest tennis players of all time, won the first of his eight grand slam titles with victory at the Australian Open, aged just 18. Incredibly, the last of those major triumphs arrived 21 years after his maiden success at Wimbledon in 1974.

The Silver Jubilee, 1977

The Queen's Silver Jubilee marked the 25th anniversary of her accession and was celebrated by millions throughout the United Kingdom and the Commonwealth. Known for her love of horse racing, Her Majesty would no doubt have had a watching eye on that year's Grand National, won that year for an unprecedented third time by Red Rum – a record that stands to this day. A week on from that event, Tom Watson edged out Jack Nicklaus in a thrilling conclusion to the Masters, and he did likewise later in the year when coming out on top at The Open.

The Golden Jubilee, 2002

The Queen's 50-year anniversary on the throne coincided with a bumper year of sport, the highlight being the 2002 World Cup in South Korea and Japan – the first time the football showpiece had been held outside of the Americas or Europe – which was won by Brazil for a fifth time. While the World Cup, Winter Olympics and Commonwealth Games garnered plenty of attention, that year's must-see one-off event was Lennox Lewis' heavyweight bout with Mike Tyson in Tennessee, with the Briton winning by knockout in the eighth round.

The Diamond Jubilee, 2012

The London Olympics was the biggest sporting event on home soil during the Queen's lifetime – bigger even than England's famous World Cup triumph of 1966 – and coincided with her Diamond Jubilee. The Games were a massive success, particularly for Great Britain, and proved one of many highlights in a remarkable sporting year. Europe produced one of the Ryder Cup's greatest ever comebacks in what is now known as 'The Miracle at Medinah', while Spain thrashed Italy 4-0 to win Euro 2012. Perhaps bigger than all that, though, was the news that Lance Armstrong had been banned from cycling for life and stripped of his seven Tour de France titles after being found to have used performance-enhancing drugs over the course of his career.

The Sapphire Jubilee, 2017

Sixty-five years is a long time, with this Jubilee making the Queen the first British monarch to hit the Sapphire milestone. Sergio Garcia's wait for a first major would have felt just as long, the Spaniard claiming victory in a sudden-death play-off with Justin Rose at the Masters in what was his 74th major. The conclusion to that tournament provided drama aplenty, yet it was nothing compared to that year's Super Bowl as the New England Patriots recovered from a 28-3 deficit to beat the Atlanta Falcons 34-28 in the largest comeback in the showpiece's history. It also remains the only Super Bowl to be decided in overtime.

Hours before beginning defence of their Super Bowl title, the Los Angeles Rams announced they have agreed to extensions with head coach Sean McVay and general manager Les Snead through the 2026 season.

McVay has led the Rams to four playoff appearances and two trips to the Super Bowl in five seasons since the team made the then 30-year-old the youngest head coach in modern NFL history in 2017.

He became the youngest coach to win a Super Bowl at age 36 when Los Angeles defeated the Cincinnati Bengals in February.

The 2017 NFL Coach of the Year's 55 regular-season victories are tied with Pittsburgh's Mike Tomlin for the third-most of any coach through his first five seasons in NFL history.

McVay also sports a 7-3 postseason record with three NFC West titles over his tenure, along with an NFC championship in 2018 that resulted in the franchise's first Super Bowl appearance in 17 years.

Snead, entering his 11th season as the Rams' GM after remaining with the team following its move from St. Louis back to Los Angeles in 2016, has also played a major part in the franchise's recent success by assembling one of the league's most talented rosters through the draft and trades.

The Rams have drafted five Pro Bowl players, most notably three-time NFL Defensive Player of the Year Aaron Donald and 2021 Offensive Player of the Year Cooper Kupp, under Snead's watch.

The 51-year-old has also established a reputation as one of the league's most aggressive and shrewd executives by acquiring several other members of last season's championship core via the trade and free agent markets.

Snead snared three-time All-Pro cornerback Jalen Ramsey from the Jacksonville Jaguars in 2019 and landed quarterback Matthew Stafford in a blockbuster trade with the Detroit Lions in March 2021.

He later made two significant in-season moves that contributed to last season's title run by trading for star pass rusher Von Miller and signing wide receiver Odell Beckham Jr.

"As an organisation we constantly strive to better ourselves every day. This requires selflessness, dedication and great leadership throughout. Sean and Les personify this mindset," Rams owner Stan Kroenke said in a statement.

"They have been crucial to many of our successes that transcend wins and losses. They epitomise the 'We, not me' mantra that permeates the entire organisation.

"We look forward to many more exciting seasons at SoFi Stadium as Sean and Les continue to play meaningful roles within the organisation and throughout the community."

Los Angeles will kick off the 2022 NFL season Thursday night at SoFi Stadium against reigning AFC East champion, the Buffalo Bills.

The NFC houses the reigning Super Bowl champions, but it enters the 2022 season viewed as the weaker of the two conferences.

Given the plethora of talented young quarterbacks residing in the AFC, the road to the Super Bowl appears to be an easier one in an NFC where the level of supply at the game's most important position is not quite as impressive.

But it would be wrong to suggest this is a conference lacking in depth, and there are several teams who could emerge as new and legitimate contenders to represent the NFC in Super Bowl LVII in Arizona.

Which teams are most likely to earn that honour? Stats Perform previews the NFC with the help of its AI season simulation and pre-season position rankings.

Favourites

No team in the league is seen as having a better chance to win the Super Bowl than the Rams, with Stats Perform AI giving the defending champions a 15.3 per cent chance of retaining the Lombardi Trophy despite the loss of Von Miller and the absence of Odell Beckham Jr, who remains a free agent following the torn ACL he suffered in the Super Bowl.

Even without Beckham, the Rams' skill position players are ranked fifth. On top of that, the Rams enter the season first in pass rush, third in pass defense and first in run defense. That's what having Aaron Donald and Jalen Ramsey on the same team will do for you.

Their most obvious competition comes from the team they beat in a Divisional Round thriller last season, though the Tampa Bay Buccaneers are projected to have just a 6.6 per cent chance to win the Super Bowl by stark comparison.

Despite the loss of center Ryan Jensen to injury and an offseason of change on the interior of the offensive line, the Buccaneers are still ranked sixth in pass protection. Tampa Bay's ability to justify that lofty position will go a long way to deciding whether Tom Brady - who had more passing plays of 25 yards or more than any other quarterback (42) in 2021 - can lead Tampa to a second title in three seasons.

Brady will have the benefit of a stacked wide receiver group, which is a luxury Aaron Rodgers and the Green Bay Packers do not enjoy as the four-time MVP launches another quest for a second Super Bowl ring.

Rodgers will be tasked with elevating a Davante Adams-less supporting cast to contention. However, though the trade of Adams to the Las Vegas Raiders dropped Green Bay's skill position players to 23rd, the Packers are still projected to win 11.5 games, the third-highest total in the NFL and a number tied in part to the continued improvements of a defense ranked third in pass rush and 10th in pass coverage that could give Rodgers the support he needs for a deep postseason run.

In the mix

The Philadelphia Eagles, Dallas Cowboys and Minnesota Vikings combined to win a grand total of zero playoff wins in the 2021 season.

Yet all three are projected to threaten double-digit wins in 2021.

Philadelphia, blown out in the Wild Card Round by the Buccaneers last season, have a win projection of 11.9, the second-highest in the NFL behind the Rams, illustrating the strength of the roster and the level of pressure on quarterback Jalen Hurts as he heads into a critical second season as the starter knowing the Eagles have the draft capital to move on from him should he fail to deliver.

The Eagles' NFC East rivals the Cowboys have a win projection of 11 even after an offseason in which they traded wide receiver Amari Cooper and lost edge rusher Randy Gregory in free agency. Dallas will also start the year without left tackle Tyron Smith after he suffered a knee injury that will keep him out until December.

Though the Cowboys head into the season ranked sixth in pass defense, much of their success in that area was tied to takeaways and an 11-interception season from Trevon Diggs that history says is unlikely to be repeated. This is a roster that lacks depth in several key areas and the onus will be on Dak Prescott to maintain the form that saw him finish 2021 fifth in quarterback Efficiency Versus Expected (EVE) - which measures performance in expected passing situations compared to the league average - for the Cowboys to live up to their projection.

Minnesota are also predicted to produce an 11-win season in their first under the guidance of new head coach Kevin O'Connell, who will have a top-seven quarterback by EVE last season in Kirk Cousins and a skill-position group that goes into the campaign ranked eighth to work with as the Vikings aim to keep pace with the Packers in the NFC North.

Will Lance live up to expectations?

The most pertinent question in the NFC surrounds the San Francisco 49ers, who are given just a 10.6 per cent chance of making the playoffs for the third time in four seasons despite possessing one of the better all-round rosters in the league and coming within minutes of beating the Rams in the NFC Championship Game back in January.

Doubt around the Niners' ability to contend again is based on the complete unknown that is Trey Lance, the third overall pick from 2021 with just two NFL starts to his name.

Lance takes over from his now backup Jimmy Garoppolo, who was 10th in QB EVE in 2021, and the move from Garoppolo's down to down efficiency to a quarterback who is, for all intents and purposes, coming off a redshirt year, is a significant factor behind the Niners' projection of 7.1 wins.

Yet Lance is a quarterback with the big-play upside as both a passer and a runner to take an offense that finished 2021 first in EVE to an even higher level, and he will be working with a group of skill-position players ranked as the league's sixth best.

Supported by a defense that, according to the rankings, boasts the second-best pass rush and a top-seven pass coverage unit, Lance is in a tremendous situation to vindicate his lofty draft status.

Should he do so, an ultra-talented team will likely dramatically outperform their projection. If he endures the kind of growing pains associated with rookie quarterbacks, the Niners may be tempted to revert back to Garoppolo. It is that range of outcomes that makes the 49ers the most interesting team in the NFC if not the NFL.

Time to believe in the Saints?

The final few days of build-up to the new season have brought some perhaps unexpected hype about the prospects of the New Orleans Saints.

Is it justified? Well, their projection seems to suggest they have a strong chance of making it to the dance, New Orleans going into the season tied with the Los Angeles Chargers tied for the 10th-best playoff odds in the league at 60 per cent.

It is not overly difficult to make a case for the Saints, who retain one of the premier defenses in the NFL. New Orleans' defense is ranked first against the pass and fifth against the run. The coordinator who has overseen that defense, Dennis Allen, is now the Saints head coach after Sean Payton stepped away.

On offense, Alvin Kamara is a dual threat on the ground and as a receiver from the running back position, while the Saints are hoping Michael Thomas can get back to his All-Pro best at wideout after playing just seven regular-season games in the last two years.

The problem is that much of the external belief in the Saints appears to be built on hope rather than evidence. They are hoping Thomas can return to his old self, that Chris Olave can quickly become a rookie sensation at receiver and that Jameis Winston's encouraging seven-game pre-injury stretch last season was not a mirage.

Simply put, the Saints need a lot to happen for them to truly contend as many seemingly expect them to, but the undoubted quality of their defense does at least give New Orleans a reasonably high floor.

New quarterbacks, new places, same old results

Baker Mayfield and Carson Wentz will each ply their trade in new locations following offseason trades.

Mayfield will look to rehabilitate his career with the Carolina Panthers while the Washington Commanders are the latest team to tell themselves they can succeed with Wentz.

Reality, however, begs to differ.

Even in what was a largely turnover-free 2021 season for the Indianapolis Colts, Wentz was still only 23rd among quarterbacks (min. 100 attempts in expected passing situations) in QB EVE.

It is no surprise, then, that the Commanders are projected to win 7.9 games, and spend another year mired in mediocrity, with Wentz unlikely to be helped by a skill-position group lacking proven playmakers outside of Terry McLaurin and ranked 31st in the league.

Mediocrity will also be the order of the season in Carolina, with the Panthers' reward for an offseason in which they traded draft capital for both Matt Corral and Mayfield a win projection of 6.8. Seven wins would represent an improvement for head coach Matt Rhule but is unlikely to be enough progress to prevent the Panthers from cleaning house come the end of the campaign.

Despite having a history of holding football grudges, Carolina Panthers quarterback Baker Mayfield took the high road when addressing Sunday’s game against the Cleveland Browns, his former team.

Mayfield left the Browns in the offseason, following their move for DeShaun Watson, to join the Panthers, with the two sides to meet in Week 1.

"It's a great storyline," Mayfield said on Wednesday. "Obviously, there's history leading up to this week. [But] there's other games in the NFL that guys are playing their former team. It's just the excitement of leading up to Week 1 that is building that anticipation up. It's the familiarity."

The Browns drafted Mayfield first overall in 2018 but chose to replace him this offseason by acquiring Watson.

Speaking to reporters on Wednesday, Mayfield acknowledged that a game against so many former teammates can be a bit different, but he denied having any resentment towards the Browns organization.

"Any time you're playing guys you know, it makes it just more interesting, more fun," Mayfield said. "You get to smack talk with your buddies that you've been with for a little bit. You know how to poke and prod and get the best out of them.

"I'm looking forward to the opportunity.

"I'm grateful for the time I had in Cleveland," he said. "I started my career there. The fans there, it's a football town. As I mentioned multiple times it ended abruptly and unexpectedly, but we're here now.

"Everything happens for a reason. I'm rolling with the punches. I'm happy to be a Panther."

Mayfield won the job as the Panthers’ top quarterback over last year’s starter, Sam Darnold.

Mayfield was 30-30 starting under center for the Browns and helped give the franchise its first playoff win since the 1994 season.

Baltimore Ravens quarterback Lamar Jackson is seeking a massive contract extension, but he is just not willing to let negotiations interfere with the 2022 season.

Jackson set Friday as the deadline to work out a new deal before shutting down negotiations to focus on the regular season, ESPN reported.

"As of right now, we're still talking," Jackson said after practice Wednesday. "The week isn't over yet."

The Ravens open the season by visiting the New York Jets on Sunday.

If a new contract isn’t signed in the next two days, Jackson will play the 2022 season on the fifth-year option of his rookie deal, netting him $23 million.

The quarterback market has been booming this offseason, with Deshaun Watson, Kyler Murray and Russell Wilson each signing extensions with an average annual value of at least $46 million.

At 25-years-old and with an MVP award already on his mantle, Jackson could be looking for even more than that.

Jackson was unwilling to comment on whether he and the Ravens are close to a new deal.

"I have no clue," Jackson said. "You have to ask the guy who I'm talking to. You talk to the GM [Ravens' Eric DeCosta] about that."

Cornerback Marlon Humphrey and tight end Mark Andrews are among the Baltimore players who have said publicly that Jackson has kept his focus on preparing for the season and that the contract negotiations have not been a distraction.

Still, Jackson has been clear that he would like to secure his long-term future in Baltimore sooner rather than later.

"It was a pretty big risk [playing] last season. The year before," Jackson said. "I'm just playing football.

"Anything can happen. God forbid the wrong thing happens."

With a new NFL season brings another chance to gain bragging rights over your friends in the world of fantasy football.

The 2022 campaign begins with a fascinating clash between the Buffalo Bills and Los Angeles Rams at SoFi Stadium, one which should have plenty of fantasy intrigue given the plethora of offensive playmakers on show.

While fantasy players around the globe will need to have their lineups set in time for kick-off in Inglewood, it is the Sunday slate Stats Perform is concerned with this week.

Here we have picked out four offensive players and a defense who should be in your line-up for the opening week, provided of course you had the good sense to draft them.

Quarterback: Jalen Hurts, Philadelphia Eagles @ Detroit Lions

One of the quarterbacks under the most pressure to perform in 2022 gets a soft landing to start the season.

Hurts didn't have to do much to help the Eagles to a 44-6 beating of the Lions last season, but the dual threat should be licking his lips at the prospect of facing a defense that last season allowed the fourth-most yards per game (379.8) in the NFL.

Only four teams allowed more rush yards per game (135.1) than the Lions in 2021 and, despite some impressive offseason additions, there is little to suggest Hurts should not be able to excel on the ground and through the air in the season opener.

Running Back: Dalvin Cook, Minnesota Vikings vs. Green Bay Packers

The Packers made steps to improve their run defense in the offseason, but slowing down Cook figures to be a difficult challenge.

Cook has eight touchdowns in his last five games against the Packers (seven rushing, one receiving), a run that has included two 150-yard performances on the ground.

Playing in Kevin O'Connell's offense, Cook should continue to receive a lot of the wide zone carries that suit his playing style, making him a candidate for another big game in what should be a compelling contest.

Wide Receiver: Michael Pittman, Indianapolis Colts @ Houston Texans

Pittman produced his first 1,000-yard season in his second year in the league in 2021 and will unquestionably be the top target for new quarterback Matt Ryan in this campaign.

That is a very favourable position for Pittman to be in against a Texans team that allowed the third-most yards per pass play (7.12) in the NFL in 2021. Look for Ryan and Pittman to combine consistently to exploit Houston's vulnerability defending the pass.

Tight End: Mark Andrews, Baltimore Ravens @ New York Jets

Andrews has cemented himself as one of the top tight ends in the NFL and an extremely popular selection in fantasy football.

This week, he is an absolute must start against a Jets defense that should be improved after a strong offseason but surrendered the third-most passing yards in the league in 2021.

No tight end in the NFL was targeted more often than Andrews (153) last season and he should expect to be the favoured weapon of Lamar Jackson as the Ravens plot a return to the playoffs. The route to the postseason starts against the Jets, and the combination of his role and the opponent should deliver a productive start to the season for Andrews.

Defense/Special Teams: San Francisco 49ers @ Chicago Bears

Week 1 can be strange, but the season opener at Soldier Field has all the hallmarks of a mismatch, one which San Francisco's defensive line should utterly dominate.

The 49ers' pass rush, led by Nick Bosa - who had 15.5 sacks last season - is ranked second in the NFL by Stats Perform AI, while the Bears' offensive line is ranked as the second-worst.

That is a recipe for a game in which the 49ers put Justin Fields under constant pressure and force a plethora of negative plays and turnovers en route to victory. Slide the Niners' defense into your line-up and profit.

The Buffalo Bills and emerging tight end Dawson Knox have agreed to a four-year extension through the 2026 season.

Knox, whose nine touchdown catches in 2021 tied for the most in the NFL for a tight end, will receive $31million guaranteed, according to NFL.com, with the total value of the deal coming in at $53.6m.

The 25-year-old Knox was entering the final season of his rookie contract.

"I couldn't be more excited to call this place home for another four years," Knox said in a social media post after the Bills announced his extension on Wednesday. 

"Can't wait to get this season rolling. Go Bills!"

A third-round pick of Buffalo in the 2019 draft, Knox compiled 52 catches for 676 yards and five TDs over his first two seasons before delivering a breakthrough 2021 campaign. 

The Mississippi State product set a franchise record for touchdown catches for a tight end and posted career highs of 49 receptions and 587 receiving yards in 15 games.

Knox added two more TD catches in Buffalo's 47-17 rout of the New England Patriots in the opening round of last season's AFC playoffs.

The fourth-year pro has also developed a special bond with the city of Buffalo, one which has grown stronger from the community's reaction to the sudden death of Knox's brother, Luke, in August. 

Bills fans raised over $200,000 in Luke's name to the P.U.N.T. foundation, a pediatric cancer charity that Dawson Knox has actively supported.

"The amount of texts I've gotten, the messages, the posts, the moment of silence for the preseason game – it's just been everything that I expected out of Buffalo and more because this city is incredible," Knox told the Bills' official site earlier this week.

"This is such an incredible city with such an incredible fan base and people. It really truly does feel like home. 

"I know I've said that before, but I kind of realised that for the first time when I came back up here after everything that it really does feel like a second home to me."

Luke Knox, a linebacker at Florida International University, died unexpectedly of unknown causes last month at the age of 22.

The New York Jets entered the week with Zach Wilson "possible" to start the season opener, but those hopes have now been dashed.

Coach Robert Saleh announced on Wednesday that the second-year quarterback would be sidelined until Week 4 at the earliest.

On Monday, Saleh said it was possible Wilson would be on the field against the Baltimore Ravens after he threw some passes and tested his right knee during a workout.

Wilson suffered a bone bruise and torn meniscus in the knee while scrambling in the Jets' preseason opener on August 12.

The 23-year-old had successful arthroscopic surgery four days later, and the original diagnosis was he would be out for two to four weeks.

Saleh, however, is now saying Wilson will be out until at least October 2, when his team face the Pittsburgh Steelers.

"We are going to make sure both mind and body are 110 per cent and make sure we do right by him," Saleh told reporters. "And we feel talking to the doctors and everyone, it's going to be that Pittsburgh week.

"After all the information gathering, it's just not worth the risk in terms of getting him out there. There's the knee element, there's the mind element, there's the practice element, there are a whole lot of things other than the knee."

Joe Flacco will feature on Sunday when the Jets host the Ravens. He spent his first 11 NFL seasons with Baltimore and guided the team to a championship in 2012 while being named Super Bowl MVP.

The 37-year-old Flacco is the Ravens' all-time leader in passing yards (38,245) and touchdown throws (212).

"I've been in a bunch of games where guys have played their past teams," Flacco said. "Usually, the emotions are definitely crazy. Guys try to act like they're so cool during the week. I've probably thought about it a tiny bit."

The Buffalo Bills are a team who have come to be defined by the agony they have suffered.

Though they are responsible for one of the most dominant stretches of offensive football in NFL history in the late 1980s and early 1990s and have more recently re-emerged as one of the most exciting teams in the league, the Bills are still yet to experience the ultimate glory of lifting the Vince Lombardi Trophy. 

Buffalo finished in the top seven for yards and points every year between 1989 and 1993 as the Bills' K-Gun offense illustrated just how devastating a no-huddle attack could be. Yet Marv Levy's star-studded group is best remembered for losing four successive Super Bowls between 90 and 93.

And Bills fans would be forgiven for pessimistically thinking the Josh Allen era is doomed to end without a first Super Bowl win in franchise history.

Allen has silenced critics who doubted his ability to improve his accuracy to become one of the most dynamic quarterbacks in the modern NFL, and the Bills have been in the top five in offensive yards and points in each of the last two seasons.

However, those campaigns have both delivered heartbreaking playoff losses to the Kansas City Chiefs, the Bills on the wrong end of one of arguably the finest postseason game in NFL history, losing 42-36 having allowed the Chiefs to drive for a game-tying field goal in the final 13 seconds of regulation.

The Four Falls of Buffalo, as they were labelled in a 30 for 30 documentary about the Super Bowl losses, and '13 seconds' will forever live in franchise infamy.

But the Bills head into 2022 with a case for being the strongest team in the league. So, as they prepare to face the defending Super Bowl-champion Los Angeles Rams in Thursday's mouth-watering season opener, how can Allen and Co. soothe the wounds of those missed opportunities by finally getting over the hump this season?
 

Taking the pressure off Allen

It may be a perplexing statement to read given Allen is fifth in passing yards (8,951) and fourth in passing touchdowns (73) over the past two seasons, but the Bills could maximise the impact of having the luxury of a quarterback of his talents by taking some of the pressure off his shoulders.

Buffalo's front office appeared to realise that this offseason, selecting running back James Cook in the second round of the draft.

Cook's burst through the running lane and up to the second level makes him an ideal fit for an offense that has found success with outside zone run concepts.

The Bills called outside zone on 21.26 per cent of their run plays last year, above the NFL average of 19.1. They put up 4.51 yards per play on such runs, again better than the league-wide average of 4.32.

Cook is a home-run hitter who can weaponise the threat of such runs in a way Devin Singletary and Zack Moss cannot. The Bills had 60 runs of 10 yards or more in 2021, the seventh-most in the NFL, but 28 of them came from QB Allen (Singletary had 20 while Moss delivered only six).

Should Cook's 4.4 speed translate to the pros, the Bills would have a back with the skill set to allow them to increase their menu of wide zone runs and make the zone-read more of a weapon. Despite the threat of Allen as a runner, the Bills averaged just 3.67 yards per play on zone-reads last season.

The Bills turned to run game on only 34.7 per cent of offensive snaps in 2021 and, when they did, the ball frequently remained in the hands of Allen, who has carried the ball 422 times since entering the NFL in 2018, a number second only to that of Lamar Jackson (615) among quarterbacks. Last season accounted for 122 of thsoe, with Jackson (133) and Jalen Hurts (139) the two signal-callers to attempt more runs.

Cook's arrival can take some of the onus off Allen as a runner, while the former Georgia back will hope to give his QB a few more easy buttons in the passing game.

His average of 10.9 yards per reception in a college career that spanned from 2018 to 2021 was seventh in the Power 5 in that time and first in the SEC, while Cook also racked up 11 receptions of at least 10 yards in 2021, tied for 12th among Power 5 backs.

Playing in an offense that has seen Allen consistently push the ball downfield -- Derek Carr (72) and Russell Wilson (70) were the only two quarterbacks to attempt more passes of at least 21 air yards last year than Allen's 68 -- Cook should have substantial space in underneath areas to exploit as a receiver.

If Allen takes advantage of those high-percentage throws when they come available, it will decrease the pressure on him to make the highlight reel passes to which the NFL universe has become accustomed, yet potential improvements in his accuracy could also have a massive bearing on his and the Bills' success in 2022.
 

Allen's extra 1%

Across the Wild Card Round of the playoffs, in which the Bills did not punt and scored a touchdown on every drive against the New England Patriots, and his equally remarkable performance in the '13 seconds game', Allen completed 77.4 per cent of his passes for 637 yards, nine touchdowns and zero interceptions.

He averaged 10.27 yards per attempt and had a passer rating of 149.0 in an incredible finale to a campaign that makes talk of finding areas for improvement seem bizarre.

Yet the best athletes are always striving to find that extra one per cent and Allen looks to have indentified where his potentially lies.

"I think, myself especially, making sure I'm on time, making the right reads and giving our guys good enough balls to get some some more RAC [run after catch]," Allen said during the offseason.

"That's one thing I think, on offense, run after catch was wasn't very high last year, but again, that's me putting the ball where it needs to be and allow our guys to catch in a good position to make a run after the catch.

"So working on that, that's been been one of my biggest takeaways in this offseason and trying to work on just ball placement and allowing our receivers to do that."

Allen's assessment is backed up by the numbers. Among 31 qualifying quarterbacks, Allen was last in yards after catch per reception with an average of just 4.5 in a season where his well-thrown percentage dropped significantly.

In his breakout 2020 season, Allen produced an accurate, well-thrown ball on 80.5 per cent of his pass attempts, the seventh-best ratio among quarterbacks with at least 100 attempts. Last season, his well-thrown rate fell to 77.2, below the league average of 78.1 for signal-callers to reach three figures in attempts.

Though the difference in his YAC per reception was negligible -- Allen averaged 4.6 per completed pass in 2020 -- there is no doubt the Bills' offense would benefit from him rediscovering the accuracy of two seasons ago.

Emmanuel Sanders and Cole Beasley have departed, but Stefon Diggs and the emerging Gabriel Davis represent two top two pass-catching weapons for Allen, and he also has two new targets for 2022 who should each thrive if he can do a better job leading his receivers.

Veteran Jamison Crowder has averaged 4.6 yards after catch per reception since 2019, almost a full yard more than Diggs (3.7) and rookie fifth-round pick Khalil Shakir possesses the vision, fluidity and love of contact to excel with the ball in his hands.

Allen improving his anticipation will go a long way to helping the Bills meet the expectations they face in 2022, but he could still use a helping hand from a loaded defense that was not without its own imperfections last year.
 

A more prolific pass rush

The Billls' headline addition of the offseason was that of Von Miller, the veteran edge rusher who arrived after displaying the plentiful amount of fuel he still has in the tank during a sojourn with the Los Angeles Rams that ended with his second Super Bowl title.

Miller finished the season with a stunt-adjusted pass rush win rate of 43.4 per cent, which was the fifth-highest among edge rushers with at least 100 one on one matchups.

Between Week 15 of the regular season and the Rams' Super Bowl triumph, Miller racked up nine sacks. Only in the NFC Championship Game against the San Francisco 49ers did he fail to bring down the quarterback.

No surprise then, that Miller's acquisition sees the Bills pass rush enter the season fourth in Stats Perform's postional rankings.

Justifying that ranking is another matter, however.

The Bills did an excellent job of pressuring opposing quarterbacks last season, in which they were sixth in pass rush win rate. Yet there is clear room for improvement in converting those pressures into sacks. Buffalo registered 42 sacks in 2021, 39 of them for negative yardage - that latter number good enough for 12th in the NFL.

Buffalo will look for Miller to vastly improve the Bills' ability to turn pressures into negative plays, though the former Denver Bronco cannot do it alone. Gregory Rousseau, Carlos 'Boogie Basham' and A.J. Epenesa all had pressure rates below 17 per cent last season as the trio of edge rushers selected highly by the Bills over the course of the last two years struggled to justify their respective draft statuses. On the interior, Ed Oliver has never had more than five sacks since being picked in the top 10 in 2019.

It was in the Divisional Round where the Bills need for extra pass-rush help was encapsulated. Buffalo pressured Patrick Mahomes 23 times but registered just two sacks.

Any kind of disruption is production when it comes to the pass rush. Pressure often leads to critical mistakes, but the likes of Mahomes and his contemporaries have grown so adept at dealing with it - Mahomes threw just five interceptable passes on 194 attempts under duress last season - that is simply not enough to get into the backfield and expect bad results for the offense.

Simply put, the Bills must do a better job of ensuring their successful pass rushes pay dividends and consistently put opposing aerial attacks in disadvantageous situations

Success in doing so would improve the odds of an extremely talented secondary surviving cornerback Tre'Davious White's early-season absence and create more chances for an opportunistic defense to produce turnovers going up against offenses working from behind the chains.

The Bills' inconsistency in turning pressure into sacks, their need for more YAC and perhaps a less Allen-centric run game are all minor blemishes for arguably the most complete team in the NFL.

Yet small issues can quickly become significant problems in the spotlight of the postseason, and it would grealy behove the Bills to iron out the imperfections that could impact their hopes of finally ending their tortuous wait for a title.

The idea of "any given Sunday" is what makes the NFL so compelling.

Any one team can beat another, and that means at this stage of the season, with the first snap still to be taken, every team can have Super Bowl aspirations.

Sort of.

The Cincinnati Bengals, for example, may have been slightly surprising contenders in 2021, but there remain some teams whose title hopes are so remote as to be non-existent.

For some, this is because they have missed their shot at glory in recent years; for others, the plan is to challenge in seasons to come.

So, this leads us to draw up a preseason tier system, ranking all 32 teams by their Super Bowl windows with the help of Stats Perform AI predictions...

Nowhere near

This is unlikely to be a season to remember for the teams grouped in this category, for a variety of reasons.

The Houston Texans won the AFC South in 2018 and 2019, but the Deshaun Watson saga and two down years have them looking at a rebuild, with the data forecasting just 4.8 wins this year. That at least ranks them ahead of the Atlanta Falcons (3.6 projected wins) and the New York Giants (4.2), while the Texans did gain draft assets in the Watson trade.

The Chicago Bears are the fourth and final team projected to earn fewer than six wins (4.9), with second-year quarterback Justin Fields receiving little help on offense and playing behind an offensive line ranked 31st in pass protection.

Meanwhile, the Washington Commanders rank 31st in terms of skill players – better only than the Falcons – with faith in Carson Wentz long since having diminished. In Baker Mayfield and Sam Darnold, the Carolina Panthers have two high-draft-pick QBs unlikely to trouble the postseason. The New York Jets are in a similar boat, even if Zach Wilson is still young.

The Detroit Lions might argue they do not deserve to keep such company after a 3-3 finish to last season, but nobody could seriously argue they are title contenders.

Entering contention

If that first group was a mixed bag, so too is the second.

Anyone who has paid any attention to the New England Patriots' preseason would suggest they are very fortunate to be given any hope of success in the near future, but they finished with 10 wins in 2021 – even if that number is projected to shrink to 7.7. Despite a trade for Tyreek Hill, that still ranks the Patriots comfortably ahead of the Miami Dolphins (7.0), although the losing team in their Week 1 meeting will face a long slog of a season.

At the other end of the spectrum, the Philadelphia Eagles are forecast to have 11.9 wins – the second-most in the NFL – after a very strong offseason. But Jalen Hurts, for now, is unproven in the postseason, so Philly fans may have to stay patient.

The San Francisco 49ers are even younger at QB after promoting Trey Lance to a starting role, which explains why the prediction model looks so unfavourably on a team many consider contenders right now. Just 7.1 projected wins speaks to the potentially low floor Lance brings.

NFC West rivals the Arizona Cardinals have to be considered among this group of future hopefuls, with Kyler Murray hugely talented and now committed long term but frustratingly inconsistent, while the Jacksonville Jaguars will hope Trevor Lawrence can follow in the footsteps of the Bengals' Joe Burrow – the number one pick the year before him.

The Los Angeles Chargers, with 9.8 projected wins, have Justin Herbert to lead their charge, while the Cleveland Browns might have been contenders already if not for Watson's suspension, which is enough to limit them to a still strong 9.3-win forecast.

In their prime

The Chargers may have Herbert, but they also have three division rivals who intend to win and intend to win now. Indeed, all four AFC West teams rank in the top half of the league in terms of projected wins, with the Chargers second – behind the Kansas City Chiefs (11.5) and just ahead of the Denver Broncos (9.7) and the Las Vegas Raiders (9.2).

The Chiefs lead the AFC in this regard, although their playoff win over the Buffalo Bills last season came down to a coin flip, and the two are set to be similarly tough to separate this year. Buffalo are down for 11.1 wins.

The two teams coming off a Super Bowl run are of course prominent among the contenders, even if the model has far greater optimism for a Los Angeles Rams repeat than for another Bengals charge. The Rams are backed for a league-leading 12.4 wins and given a 15.3 per cent shot at defending their title, while the Bengals are actually projected to dip below .500 with 8.2 wins.

The Bengals' route to the Super Bowl will be complicated not just by the AFC West and the Bills but also by any return to form for the fit-again Lamar Jackson's Baltimore Ravens, who are counted among nine teams on course for 10 or more wins (10.4).

Also in that group are NFC pair the Dallas Cowboys (11.0) and the Minnesota Vikings (10.9), who may not even be the best teams in their divisions but might be nearing a point when they must seriously challenge or start again, which brings us to...

Last chance saloon

As long as Tom Brady and Aaron Rodgers are the QBs for the Tampa Bay Buccaneers and the Green Bay Packers, those teams are in with a chance. The question is how long that will remain the case.

Brady is 45, briefly retired this offseason and then missed a chunk of the preseason. Rodgers is 38, has repeatedly been linked with a move away from Green Bay and lost top target Davante Adams ahead of the new season. Still, the Buccaneers rank eighth for projected wins (10.7), with the Packers up in third (11.5).

They are not the only ageing teams in the NFL, however.

The Indianapolis Colts hope they have upgraded in moving from Wentz to Matt Ryan, yet the former MVP is now 37 and last played in the postseason in 2017 – when Wentz's Eagles took the title.

Tennessee Titans QB Ryan Tannehill is a little younger at 34, but of greater concern would be Derrick Henry's durability after the injury that limited to eight games last regular season. The Titans need to make the most of any seasons they have left of the superstar running back going at full tilt.

Missed their chance

Russell Wilson, Ben Roethlisberger and Drew Brees won Super Bowls with the Seattle Seahawks, the Pittsburgh Steelers and the New Orleans Saints respectively, but with all three having now moved on, it is difficult to see those teams plotting a path to the title.

For the Seahawks and the Steelers, this will be their first year without their stalwart QBs, even if things had already gone stale in 2021. Wilson dipped below the .500 mark for a season for the first time in his career, while Pittsburgh were attempting to stay competitive in spite of Roethlisberger rather than because of him.

Still, with both gone – Wilson to Denver and Roethlisberger to retirement – there is a void under center that has not been suitably filled. Seattle also rank 32nd in pass protection, likely leaving Geno Smith hopelessly exposed.

The Saints have had another 12 months to come to terms with Brees' exit, albeit they spent it juggling Jameis Winston, Trevor Siemian and Taysom Hill at QB. Winston's season-ending injury doomed the Saints' hopes of contention last year, and New Orleans' outlook for 9.5 wins with the entertaining but erratic former number one pick is at least far more positive than that of the Seahawks (6.2) or the Steelers (7.0).

Regardless, each of these three teams have provided an example in how not to do succession planning. They all could have won additional honours with their departed veterans and now face long waits for further title tilts.

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