The Buffalo Bills will have revenge on their mind against the Chiefs, having seen their past two seasons reach a disappointing climax in Kansas City – including a 42-36 overtime defeat in the divisional round this year.

Widely tipped as the favourites to go all the way this season, the Bills enter the Week 6 contest on the back of a 38-3 drubbing of the Pittsburgh Steelers last week. 

That was their second win by at least 34 points this season – having had multiple such wins in just two previous seasons (1992 and 2021).

Against the Steelers, Gabe Davis had two touchdown receptions of at least 60 yards and finished with 171 yards, taking his yardage for the season to 309. An in-form Davis is a frightening prospect, particularly when paired with Josh Allen – who leads the NFL for passing yards this season (1651).

The Chiefs have a devastating weapon of their own to lead the offense though, with Patrick Mahomes fresh from guiding his side to a 30-29 victory against the Las Vegas Raiders in Week 5 – the 40th occasion the Chiefs have scored at least 30 points since Mahomes took over as the full-time starter in 2018.

Ranking fifth for passing yards this season (1398), Mahomes has thrown more TD passes than anyone else in 2022 (15) and has a TD with 7.9 per cent of his passes, behind only Lamar Jackson (8.1 per cent).

In Travis Kelce, the Chiefs also boast the player with the most receiving touchdowns in 2022, with four of his seven coming last week – despite totalling just 25 receiving yards over the course of the game.

With elite quarterbacks and receivers on both sides, the defenses could decide the outcome of the game and the Bills have been relentless with their ability to keep opposing offenses at bay, allowing 61 total points across five games – only the San Francisco 49ers (61) having less.

On top of that, the Bills defense has allowed only three passing TDs this season, again behind only the 49ers (two), and rank second for the least yards allowed per game on average (260.4), meaning it could be a frustrating game for Mahomes and company come Sunday.

The NFL season is well under way, with Week 6 set to mark the point where over a third of the regular season has been played.

Playoff hopes are starting to rise and crucial games are on the horizon, with the Minnesota Vikings looking to provide a further boost against a Miami Dolphins side that have lost their rhythm after a perfect start.

Elsewhere, revenge is on the cards for the Buffalo Bills against the Kansas City Chiefs, who have shattered their dreams in back-to-back seasons, while there is plenty on the line in the NFC East contest between the Philadelphia Eagles and the Dallas Cowboys.

With a wealth of entertainment on offer, Stats Perform has crunched the Opta data to preview this weekend's contests.

Minnesota Vikings (4-1) @ Miami Dolphins (3-2)

After starting the season 3-0, the Dolphins have suffered back-to-back defeats by 12 and 23 points respectively, becoming only the second team in the Super Bowl era to start a campaign 3-0 but then lose their next two games by at least a dozen points – the other being the 1994 Chiefs.

However, the Dolphins have won their last three games against NFC teams by double-digit scores, marking the first time they have had such a streak against the NFC since a five-game stint from 1978 to 1979.

With quarterback duo Tua Tagovailoa not expected to return this weekend and Terry Bridgewater out due to concussion, rookie Skylar Thompson looks set to make his first career start against the Vikings and will need help from Tyreek Hill, who is the only player in NFL history with at least 7,000 receiving yards, 7,000 rushing yards and 700 punt return yards in his career.

The Dolphins' clash with the Vikings could go down right to the wire, with Minnesota having trailed with less than five minutes remaining in the fourth quarter and come back to win in each of their last three matches for the first time in their franchise history, as well as being the first time any team has done so since the Lions in 2014.

The only team in NFL history to have such a comeback in four straight games was the Denver Broncos in 2011, led by quarterback Tim Tebow.

Buffalo Bills (4-1) @ Kansas City Chiefs (4-1)

The Chiefs have ended the Bills' season in each of the last two campaigns, including a 42-36 overtime win in the divisional round in 2021. In the last eight meetings, including the post season, Kansas City are 6-2, but one of those losses came at home in Week 5 last season.

Patrick Mahomes continues to be the leading man for the Chiefs, with the 30-29 victory over the Las Vegas Raiders last week marking the 40th time the Chiefs have had a game with at least 30 points since he became full-time starter in 2018. The only other team with more than 30 such games is the New Orleans Saints (35).

A tough test against the Bills defense awaits, however, with Buffalo allowing just three broken tackles this season, only the Washington Commanders having fewer (2). In contrast, the Chiefs' defense has allowed 12 broken tackles, only Houston and Las Vegas (both 15) having more.

Offensively, the Bills head to Kansas City on the back of a 38-3 triumph against the Pittsburgh Steelers in Week 5, marking their second win by at least 34 points this season, having beaten the Titans 41-7 in Week 2. Only in 1992 and 2021 have they had multiple such wins in a season (twice in each).

Dallas Cowboys (4-1) @ Philadelphia Eagles (5-0)

For the first time, the NFC East rivals will face off with both teams entering the contest on the back of a single-season winning streak of at least four games, and the Cowboys have a historical edge after three consecutive wins by a margin of 20 or more points.

The Cowboys have held each of their five opponents so far this season to 20 points or under for the first time since 1972, while only two teams in the last 10 years have done so in six straight games to start a season – the 2013 Chiefs (9) and 2019 New England Patriots (8).

Keeping Jalen Hurts and the Eagles offense at bay will be a stern test though, with Hurts setting an NFL record by becoming the first QB to have a five-start span, at any point, where he passed for 250+ yards per game, rushed for 50+ yards per game, rushed for 5+ touchdowns and went undefeated.

From the first five games of the season, the Eagles have averaged 400+ yards of offense and have not lost a single fumble during that span.

Elsewhere…

The Los Angeles Rams host the Carolina Panthers on the back of a 22-10 home defeat to the Cowboys in Week 5, with all three of their losses this season seeing the Rams score 10 or fewer points and lose by at least 10 points. From 2017-2021, they only had five such games.

The Arizona Cardinals head to the Emerald City boasting a strong record against the Seattle Seahawks, sitting 6-3 in the last nine road games. That is tied for the best record by any teams with at least two games played in Seattle since 2013 (Atlanta and New Orleans both 2-1).

The Cleveland Browns face the Patriots, having led at the start of the fourth quarter in all five games so far this season. However, they sit 2-3 (.400) in comparison to the rest of the NFL, which combines for 51-15-1 (.769).

Tampa Bay Buccaneers QB Tom Brady is tied with Charlie Conerly for most career passing touchdowns against the Steelers (29 each), who he faces in Week 6. With one more, the Steelers would become the fifth team Brady has thrown at least 30 TD's against – joining the Colts, Jets, Dolphins and Bills.

Ron Rivera angrily hit out as suggestions he was not an enthused as Washington Commanders owner Daniel Snyder by the signing of quarterback Carson Wentz.

In the wake of Thursday's 12-7 win over the Chicago Bears at Soldier Field, coach Rivera was in fiery form at his post-game press conference, eventually calling a halt to proceedings himself.

ESPN this week quoted an unnamed source as saying that the signing of Wentz in a March trade from the Indianapolis Colts was "100 per cent a Dan move".

Wentz came into the Bears game carrying a bicep injury, managing only 12 of 22 passes for 99 yards with no TDs.

However, Rivera wanted to make it clear that his own role in the signing of Wentz was integral to the trade going ahead.

"Everybody keeps wanting to say, I didn’t want anything to do with Carson," Rivera said.

"Well bull****. I'm the f****** guy that pulled out the sheets of paper, that looked at the analytics, that watched the tape when we were in Indianapolis.

"That's what p***** me off, because the young man doesn't deserve to have that all the time. I'm sorry, I'm done."

The expletive-laden torrent from Rivera followed an assessment of how the team's 1-4 start had been wearing on his players.

Finally getting a second win, after losing four straight games, came as a relief to Rivera, prompting him to unload.

Brian Robinson Jr scored the decisive touchdown, two months after being shot in the knee and glute in an attempted carjacking on August 28.

"Honestly it's been hard. It really has. You lose four games in a row and everybody wants to get on you," Rivera said.

"They've played their a**es off. They've played their a**es off for everybody. They come out, they show up, and they work hard, they don't complain.

"They hear all this stuff and they've got to deal with that. I respect them for that because they're resilient."

Suspended Cleveland Browns quarterback Deshaun Watson had another civil lawsuit filed against him, alleging he pressured a woman into oral sex in a massage session in 2020.

The lawsuit is the 26th known filed against Watson, who is currently serving an 11-game NFL-imposed suspension for violating the league's personal conduct policy by committing sexual assault on massage therapists.

Former Houston Texans QB Watson has settled 23 of the lawsuits over the past few months, with one outstanding and one dropped.

The latest lawsuit filed on Thursday evening stated Watson "continually pressured [the plaintiff] into massaging his private area" before he "removed his towel" and "offered to let her 'get on top'." The lawsuit added that the plaintiff refused to have sex with Watson but was pressured into performing oral sex.

The plaintiff has suffered from severe depression and anxiety since the alleged incident, according to the lawsuit.

"My client's experience with Deshaun Watson follows a series of disturbingly similar encounters reported by more than 20 women who have filed suit against the NFL superstar," the woman's lawyer, Anissah Nguyen told ESPN.

"Like so many others, my client spent nearly two years struggling to cope with the shame and trauma from all that he has stolen from her and the daily pain that has become her reality.

"Knowing her story will bring on the hard conversations, criticism and even victim-blaming, the strength and bravery of these other women gave my client the courage to stand up and speak out.

"She seeks justice not only for herself and her own healing, but for the more than 20 women who refused to be shamed into silence, and the victims who have yet to come forward."

The lawsuit comes in the same week that Watson was permitted to re-enter the Browns training facility, having been banned since August 30.

The Washington Commanders snapped their four-game skid in a dour 12-7 win over the Chicago Bears at Soldier Field with Brian Robinson Jr scoring the decisive touchdown two months after being shot.

Commanders running back Robinson finished with one TD from 17 carries for 60 yards in his career-first start and second game back since being shot in the knee and glute in an attempted carjacking on August 28.

The Bears almost snatched victory with their final drive when QB Justin Fields' fourth-down pass for Darnell Mooney was completed but juggled just short of the goalline. In the previous play, Dante Pettis had dropped a Fields' throw under pressure from Darrick Forrest, although no pass interference was called.

Robinson provided the highlight in a game where no touchdowns were scored in the first half, with Joey Slye's field goal late in the second quarter snapping the scoreless deadlock.

The Bears, who fell to their third straight defeat and a 2-4 record, had taken the lead in the third quarter when Fields found Pettis in the corner. Fields completed 14 of 27 attempts for 190 yards, with one TD pass and one interception, and had 88 running yards on 12 carries.

After Slye added a 28-yard chip-shot field goal, Chicago were undone when rookie Velus Jones Jr fumbled a punt, handing the Commanders position which Robinson capitalized on in two drives.

Slye missed the chance to move the lead to eight points when he missed a 48-yard field-goal attempt inside the final two minutes, but the Bears could not capitalise.

Commanders quarterback Carson Wentz came into the game carrying a bicep injury, managing only 12 of 22 passes for 99 yards with no TDs.

Carson Wentz will start for the Washington Commanders in their clash against the Chicago Bears despite not being 100 per cent fit due to a bicep injury.

The 1-4 Commanders were unsure whether Wentz would be available for Thursday's contest due to the short turnaround after Sunday's loss to the Tennessee Titans, when he sustained the injury.

However, he threw the ball well in practice, albeit in a walkthrough session, and will lead the offense from the start against the Bears, NFL Network's Tom Pelissero reports.

The Commanders will hope that Wentz can get through the matchup against the Bears unscathed and then heal up with extra rest before their Week 7 clash at home to the Green Bay Packers, with a 10-day gap between the games.

Wentz's availability is a boost for a Commanders team already without significant members of their offense, with receiver Jahan Dotson and tight end Logan Thomas set to miss Thursday's game.

The Commanders sit bottom of the fiercely contested NFC East, where all their division rivals currently rank 4-1 or better, with the Philadelphia Eagles leading the way as the only undefeated side left across the NFL (5-0).

Bill Belichick was typically guarded when asked about Mac Jones' status as starting quarterback once he is fit to return for the New England Patriots.

Second-year quarterback Jones has missed the Pats' past two games with an ankle injury but did manage to return to practice on Wednesday.

Reports said Jones did still not have full mobility during the session, though, meaning his availability for Sunday's showdown with the Cleveland Browns remains unclear.

Bailey Zappe completed 17 of 21 passes for 188 yards, finishing with one touchdown and an interception on a steady debut outing when acting as understudy for Jones in last week's triumph over the Detroit Lions.

Head coach Belichick was asked whether Jones can return this week, to which he replied: "We'll see where he is today. I don't know."

Belichick was also non-committal about whether Zappe's performances will determine who starts under center.

"They're totally independent, it doesn't have anything to do with it," he added.

For his part, Zappe is taking things in his stride and ready to step into the breach once more should he be called upon.

''I'm preparing to do what my coaches tell me I'm supposed to be doing,'' he said. ''Right now, that's to take practice reps and do what I can do to help the team.''

The Pats are bottom of the AFC East standings through five games with a 2-3 record.

Miami Dolphins quarterback Tua Tagovailoa will miss another game due to concussion, confirmed head coach Mike McDaniel.

Tagovailoa was highly unlikely to feature in Sunday's game against Minnesota Vikings despite returning to the practice field this week, but McDaniel declared he would not play on Wednesday.

The Dolphins QB has not played since being concussed in the Week 4 game against the Cincinnati Bengals on September 29.

Tagovailoa's replacement, Teddy Bridgewater, was also concussed in their Week 5 game against the New York Jets, meaning rookie quarterback Skylar Thompson will make his first career start versus the Vikings.

"Now, when talking about this week and playing, I don't see a scenario - I don't see him being active. I do not plan to have him play at all," McDaniel told reporters about Tagovailoa.

"As far as his exact timeline of when he's going to play, I'll be excited to consider that whenever that comes up. Right now, I'm just really focused on him getting out there and feeling good and being around his teammates, and that those types of decisions aren't in the immediate future right now. I'll handle that when that comes after."

McDanel revealed Tagovailoa may pass concussion protocol the Week 6 game but that the Dolphins would not rush him back despite being depleted in that department with Bridgewater out.

"He hasn't done a thing on the football field for literally two weeks," McDaniel said.

"I don't think that that would be fair to the player. That wouldn't be fair to the team… I don't feel comfortable putting him in that situation."

Tagovailoa was stretchered off and briefly hospitalized after hitting his head on the turf and being concussed against the Bengals.

That came only four days after a similar incident against the Buffalo Bills where he was evaluated for concussion at halftime, having appeared unstable on his feet but cleared to play on.

The incident led to the NFL Players' Association conducting a review of the league's concussion protocol, which was amended last week to include ataxia as a symptom. Bridgewater was the first player impacted by the protocol change in Week 5.

The Dolphins are on a two-game losing streak, sitting 3-2 after beginning the 2022 season with three successive wins.

Aaron Rodgers was absent from the Green Bay Packers' practice on Wednesday, but head coach Matt LaFleur is not worried about his availability for Sunday's game against the New York Jets.

Rodgers injured his thumb on the final play of the Packers' 27-22 defeat to the New York Giants at the Tottenham Hotspur Stadium at the weekend.

The reigning MVP threw for 222 yards and two touchdowns, but could not prevent defeat as Green Bay slipped to 3-2 for the season.

Despite missing Wednesday's practice, LaFleur is confident Rodgers will be fit to play against the Jets on Sunday.

"I don't think we have much concern for game day," LaFleur told reporters.

The Packers sit second in the NFC North, kept off top by the Minnesota Vikings, who beat them 23-7 in Week 1.

Back to work in Green Bay. @AllenLazard | #GoPackGo pic.twitter.com/ZgdbJXbnN7

Odell Beckham Jr hit out at the Los Angeles Rams for offering him the "lowest of low" contracts, though Sean McVay expects his side will go back in with new negotiations.

The Rams wideout suffered an ACL injury in February's Super Bowl LVI as Los Angeles narrowly defeated the Cincinnati Bengals 23-20 at their home of SoFi Stadium.

Beckham Jr signed a short-term deal with the Rams last November, though it was expected he would re-sign after an impressive postseason.

The 29-year-old is yet to find a new NFL side as he remains a free agent, but a reunion with the Rams appeared seemingly unlikely after Beckham Jr revealed his disappointment with his former team.

"LA knows where I wanted to be… but they didn't offer me….anything!," he posted on Twitter.

"So [I don't know] what people want me to do, I definitely know my worth and what the offer was isn't reflective of that.

"So it's tough to say that I can come on back even though I thought I finally found that home!

"But yes, LA treated me normal and special all in the same breath, we see how that played out! For both sides.

"I went out to win a [trophy] there knowing the risk of playing without an ACL… and then I got the lowest of low offers after that going into the next season."

Beckham Jr ended the series of posts with "Impossible" followed by two laughing emojis, suggesting he values himself far above what the Rams offered.

The Green Bay Packers and the Kansas City Chiefs are said to be the favourites to sign Beckham Jr, though Rams coach McVay claimed negotiations are far from over.

"I love Odell," McVay told reporters. "We have constant dialogue. He also knows that certainly I don't think that's the last [offer] that would come from us. I'm not familiar with what it is.

"He knows how we feel about him. We've got a little bit of time. But [I] love Odell. Nothing but good things coming from me."

Dallas Cowboys quarterback Dak Prescott is unlikely to make his return following thumb surgery against the Philadelphia Eagles, according to coach Mike McCarthy.

Prescott suffered a fracture near his right thumb in the fourth quarter of the Cowboys' season-opening 19-3 loss to the Tampa Bay Buccaneers last month.

Cooper Rush has deputised ably since then, leading the team on a four-game winning streak, but Cowboys owner Jerry Jones recently said he was unlikely to keep the starting spot when Prescott returns to fitness.

Prescott was set to throw for the first time since suffering his injury following Wednesday's practice, but McCarthy is planning to start Rush against the NFL's only unbeaten team on Sunday.

"We are preparing for Cooper to start against the Eagles," McCarthy told reporters.

"I think we're still in the medical rehab phase. So once he [Prescott] clears this phase and he's fully activated, then I think that's when we have our conversation.

"You've got to trust the medical process. This is a 17-game season. That was my immediate response. I know Dak didn't want to hear it, but you've got to make sure that he's right for the long haul, too.

"So I'm not saying we're being conservative because that doesn't line up with him, with the way he approaches preparing to play. But, yeah, this really is following the medical timeline."

McCarthy also stated his belief the team's form had not been significantly altered by their change of quarterback after Week 1.

"He [Prescott] is doing all the things you can possibly do and more to get ready," McCarthy added. "But I don't think it would've changed, from my view."

Las Vegas Raiders wide receiver Davante Adams has been charged with misdemeanour assault for pushing over a photographer after his team's 30-29 loss to the Kansas City Chiefs.

Moments after the defeat, Adams was making his way from the field at Arrowhead Stadium when he shoved Ryan Zebley, a credentialed media member, who suffered whiplash and a headache as well as a potential minor concussion.

Though Adams apologised after the incident, the former Green Bay Packers wideout has now been charged for what was described in court records as an "intentional, overt act" that caused "bodily injury".

The charges were filed on Wednesday at the Municipal Court of Kansas City, and Adams is set to be in court on November 10.

Adams is also reportedly facing discipline from the NFL, though his coach Josh McDaniels defended him on Tuesday, saying: "That was an unfortunate situation. I support Davante wholeheartedly as a human being. I don't think there was any intent behind it, on his part."

The Chiefs defeat dropped the Raiders to 1-4, and their bye week means they are now not in action until October 23 when they will host the Houston Texans, though it remains to be seen whether Adams will be suspended for that game.

Miami Dolphins quarterback Tua Tagovailoa will return to team practice on Wednesday and could be cleared from concussion protocol ahead of Sunday's matchup against the Minnesota Vikings.

Tagovailoa suffered a concussion during a defeat to the Cincinnati Bengals last month and was taken by ambulance to hospital, subsequently missing the Dolphins' loss to the New York Jets.

While highly unlikely to take to the field in Week 6 against the Vikings, NFL Network's Tom Pelissero and Ian Rapoport state sources say he has made 'great strides' and is heading in the 'right direction' for a return to the field.

Tagovailoa has consulted with four independent specialists since the injury and increased his rehab work to include cardio and strength training over the weekend, while Wednesday will involve throwing the ball as part of "non-contact sports-specific activity".

The Dolphins quarterback situation is up in the air ahead of Sunday, with backup QB Terry Bridgewater also in concussion protocol and coach Mike McDaniel telling reporters on Monday there was no specific timeframe for the return of either player.

Rookie seventh-round pick Skylar Thompson took to the field in place of Bridgewater against the Jets, where he threw for 166 yards and one interception, finishing with a pass completion percentage of 57.6 per cent.

The Dolphins are on a two-game losing streak, sitting 3-2 after beginning the 2022 season with three successive wins.

Carolina Panthers quarterback Baker Mayfield will not require surgery on the high ankle sprain he suffered in the defeat to the San Francisco 49ers, which means he will not be placed on injured reserve.

The 2018 No.1 overall pick is set to be sidelined for this weekend's matchup with the Los Angeles Rams but, having avoided IR status, will be available to return within the next four games.

Mayfield, signed in a trade from the Cleveland Browns in July, suffered the injury in the loss to the 49ers, leaving the Panthers with a 1-4 record for the season, but was given a verdict of 'no major damage' after receiving second opinions on the injury, per NFL Network's Tom Pelissero.

His absence is a blow to the Panthers, who are yet to find full flow with their new cornerstone franchise QB; Mayfield having 962 passing yards, four touchdown throws and a pass completion of 54.9 per cent – which ranks as the lowest across the entirety of the NFL in 2022.

P.J. Walker is set to take over as the Panthers' starting QB while Mayfield is absent, having totalled 60 yards and an 83.3 per cent completion rate following his introduction against the 49ers in Week 4.

Across his three-year career in the NFL, Walker has played in 10 matches, twice as a starter, accumulating 790 passing yards and two touchdown throws.

The Panthers' trip to LA will be the first under the guidance of interim head coach Steve Wilks, following the dismissal of Matt Rhule on Monday.

Atlanta Falcons defensive tackle Grady Jarrett remains "clueless" regarding the controversial roughing the passer call which followed his hit on Tom Brady on Sunday.

Brady equalled the NFL record for most victories by a quarterback against a specific opponent without defeat (11) as he led the Tampa Bay Buccaneers to a 21-15 win over the Falcons.

However, Atlanta looked set to get a chance to complete a memorable comeback when Jarrett sacked Brady on third down with three minutes remaining.

But referee Jerome Boger called roughing the passer against the 29-year-old, later explaining the decision was made due to Jarrett unnecessarily throwing Brady to the ground.

The call has been met with controversy, with subsequent reports suggesting the NFL's competition committee will discuss amendments to roughing penalties after this season.

Jarrett is yet to come to terms with the decision two days later, saying: "Looking back on it, I'm still kind of left clueless on what I'm expected to do in that situation."

Kansas City Chiefs defensive lineman Chris Jones was on the receiving end of a similar call against the Las Vegas Raiders on Monday, leading Jarrett to call for change.

"I did see Chris' sack last night, and that was questionable as well," Jarrett said. "All these other things that we can review… I'm not saying that it cost us the game, but it cost us an opportunity to win the game.

"If it's costing people games, it's going to cost people livelihoods. It's going to cost people opportunities. You never know who is going to go down and make a crazy play.

"Obviously this happened to us, the Falcons, but forget all that, it's about the sport. When people watch us to be entertained, to see some game-winning drives and then when you do it right, the right way, that's what makes it so frustrating.

"So let's give the game what the game is owed, and that's the best product we can put on the field."

Speaking on SiriusXM's Let's Go! Podcast on Monday, Brady described the incident as an "unwelcome hug" from Garrett and steered clear of discussing the decision.

"It was a long hug, a long unwelcome hug from Grady," Brady said. "And he was in the backfield all day. So as I said after the games, I don't throw flags.

"What I do throw is tablets, and I didn't have one accessible at that time. He had a hell of a game. I'll leave it at that.

"I woke up this morning, I was looking around the corner everywhere for Grady Jarrett jumping out and hitting me again.

"He played such a good game against us yesterday and I had nightmares last night thinking about him. But I'm glad we're through with that game. I'm glad we won."