Serge Gnabry scored a hat-trick as Bayern Munich moved four points clear at the Bundesliga summit following a 6-1 victory over Werder Bremen.

Jamal Musiala, Leon Goretzka and Mathys Tel were also on target for Julian Nagelsmann's side, who equalled a club record by netting at least four goals in a fourth successive home league game.

It was not all positive for Bayern, though, as Sadio Mane limped off less than two weeks before the start of the World Cup, while Eric Maxim Choupo-Moting saw a penalty saved.

Werder had briefly equalised early on through Anthony Jung, yet they are now without a win in 30 meetings with Bayern.

Musiala put Bayern in front in the sixth minute, calmly slotting into the far corner after Mane's initial effort was blocked, but Werder were level four minutes later when Jung tucked home from Mitchell Weiser's lay-off.

Despite Choupo-Moting seeing his penalty saved and Mane limping off injured, the hosts regained the lead in the 22nd minute as Gnabry curled a brilliant effort beyond Jiri Pavlenka.

Bayern then hit their opponents on the counter twice in quick succession. Goretzka made it 3-1 after racing onto Joshua Kimmich's throughball and rounding Pavlenka, before Leroy Sane latched onto Choupo-Moting's precise pass and squared for Gnabry to slot into an empty net.

Julian Nagelsmann's side scarcely slowed after half-time as Sane hit the post, while Pavlenka thwarted Gnabry's attempted lob for the hat-trick.

He was not to be denied in the 82nd minute as he cleverly stepped inside a couple of challenges before poking home, and Tels put the icing on the cake two minutes later with a powerful finish into the top corner.

Sadio Mane has suffered an injury scare less than two weeks before the World Cup after limping off during Bayern Munich's Bundesliga clash with Werder Bremen.

The Senegal forward was substituted in the 21st minute at the Allianz Arena on Tuesday, having received treatment on the pitch and subsequently signalled to the bench he could not continue.

Mane was involved in Bayern's opening goal, which was scored by Jamal Musiala, but his substitution will clearly concern his country.

Senegal's World Cup opener against the Netherlands is on November 21, giving Mane little time to recover from any issue.

Manchester City director of football Txiki Begiristain believes they face a difficult task in the last 16 of the Champions League after drawing RB Leipzig.

Pep Guardiola's men will take on the Bundesliga side in the knockout stages next February, having faced them twice in the group stages last term.

On that occasion, City opened their European campaign with a 6-3 rout at the Etihad Stadium, before losing the reverse fixture 2-1 at the Red Bull Arena.

Having dodged heavyweight foes such as Paris Saint-Germain and Milan, City have theoretically one of the easier ties on paper, but Begiristain says they will not take their opponent lightly.

"Leipzig are not new ones in this competition - they are doing an unbelievable job," he said. "They are in Europe, always, and they are fighting us in the last 16. They are growing as a club and growing as a project.

"This is German football - very open, box-to-box, which we don't like too much, because we like to have the control. It's going to be difficult, this kind of football.

“We are going to meet old friends - we played last season against them. They were very open games, and we can be sure they will be very attractive games."

In comparison to their rivals, City have indeed been handed a kind draw, with Liverpool facing Real Madrid and Bayern Munich squaring up with Paris Saint-Germain.

With possibly two of the last four tournament winners set to miss out on the quarter-finals, Begiristain feels it shows the increased competition within the Champions League.

"Some big names and big clubs are already out - some of them are now not playing in Europe because they were last in the group," he noted.

"It shows how difficult it is in this competition. Everyone has to respect their opponent in this competition and that is what we try to do.

"Liverpool and Real Madrid are two unbelievable clubs, and they were two of the candidates to win, but one will be out.

"But still the ones who are there in the quarter-finals are going to deserve to be there. We want to be one of them."

Julian Nagelsmann feels Bayern Munich's 100 per cent record in the Champions League group stage was "not rewarded" after being drawn against Paris Saint-Germain in the round of 16.

Nagelsmann's men won all six group games to finish top of Group C, including home and away victories over Inter and Barcelona, becoming the first side in competition history to be victorious in all of their group matches in back-to-back seasons.

Despite this, Monday's draw pitted Bayern against French champions PSG, who boast the likes of Lionel Messi, Neymar and Kylian Mbappe in their squad.

Nagelsmann believes his team have not received the full benefit for their group-stage heroics, telling reporters: "PSG are a difficult opponent.

"The perfect group phase is not rewarded with [drawing that opponent] - they have a lot of world-class players just like we do. 

"But this is the Champions League, so it's normal that there are no easy opponents in the round of 16."

PSG themselves went undefeated in the group stage, winning four and drawing two of their matches.

But a remarkable 6-1 win for Benfica over Maccabi Haifa on the final matchday saw Christophe Galtier's team have top spot snatched off them by virtue of the Portuguese side scoring more away goals.

Bayern CEO Oliver Kahn echoed Nagelsmann's sentiments on the difficulty of the draw, but also spoke of his excitement over watching two of Europe's elite clubs face off in a repeat of the 2019-20 final, which the Bavarian side won 1-0 thanks to a Kingsley Coman winner.

"We can look forward to two great games with the best players in Europe," Kahn told Sky. "I think these will be two highly attractive games."

Real Madrid and Liverpool will contest a repeat of last season's Champions League final during the round of 16 following Monday's draw.

Madrid reached the knockout stages as Group F winners, an outcome they will have been hoping would secure them a favourable tie.

But by being paired with Liverpool, Carlo Ancelotti's men were given arguably the hardest draw possible in what will be a repeat of the 2021-22 and 2017-18 finals.

There will also be a replay of the 2019-20 showpiece between Bayern Munich and Paris Saint-Germain.

Die Roten prevented PSG from winning their first continental crown that year, with revenge on the cards for the Parisians early next year.

Chelsea, winners most recently in 2021, will go up against the youthful Borussia Dortmund, while Manchester City – beaten finalists last year – are also due to tussle with Bundesliga opposition in RB Leipzig.

Antonio Conte faces a return to his homeland and San Siro as Tottenham prepare to duel with Italian champions Milan, while Serie A leaders Napoli – who won their group ahead of Liverpool – will fancy their chances against Europa League holders Eintracht Frankfurt.

Last-16 draw in full:

RB Leipzig v Manchester City
Club Brugge v Benfica
Liverpool v Real Madrid
Milan v Tottenham
Eintracht Frankfurt v Napoli
Borussia Dortmund v Chelsea
Inter v Porto
Paris Saint-Germain v Bayern Munich

Real Madrid and Liverpool will contest a repeat of last season's Champions League final during the round of 16 following Monday's draw.

Madrid reached the knockout stages as Group F winners, an outcome they will have been hoping would secure them a favourable tie.

But by being paired with Liverpool, Carlo Ancelotti's men were given arguably the hardest draw possible in what will be a repeat of the 2021-22 and 2017-18 finals.

Atletico Madrid were eliminated from Europe in midweek after a 2-1 loss at Porto and are looking to bolster their squad.

One player who could be sold is Joao Felix, who Atleti signed for €126million from Benfica on a seven-year deal in 2019.

The Portuguese forward has underwhelmed this season, with only two goals, and has been unsettled at times.

TOP STORY – ATLETICO WILLING TO LISTEN TO JOAO FELIX OFFERS

Cadena SER claims Atletico Madrid have put Joao Felix on the market and are open to offers for him.

Bayern Munich were rumoured to have made a €100m off-season move for Felix, while Manchester United reportedly had a €130m bid turned down in August.

Fichajes reported last month that the 22-year-old had handed in a transfer request, while Paris Saint-Germain and Barcelona have been linked with him recently.

ROUND-UP

– Real Madrid are getting proactive in the pursuit of Palmeiras' 16-year-old talent Endrick, sending officials to Brazil to commence talks over a deal, claims Marca. Endrick cannot officially join Madrid until he is 18-years-old but Los Blancos are eager to get an agreement in place.

– West Ham, Leicester City, Southampton and Brentford are all monitoring Lyon's Brazilian winger Tete, according to The Sun.

– Diario Sport reports Barcelona want to sign Athletic Bilbao centre-back Inigo Martinez as a replacement for the retiring Gerard Pique.

– Leicester are weighing up their options for a Youri Tielemans replacement, keeping tabs on Lorient midfielder Enzo Le Fee, reports 90min.

– La Gazzetta dello Sport reports veteran French forward Olivier Giroud will be rewarded with a new Milan contract after the World Cup. The new deal will run until 2024.

Napoli winger Khvicha Kvaratskhelia is expected to cost €100million if the undefeated Serie A leaders choose to sell at the end of the season.

Kvaratskhelia, 21, was with Rubin Kazan for three seasons before the Russian invasion of Ukraine halted their 2021-22 campaign, allowing the Georgia-born player to sign with Georgian club Dinamo Batumi.

Napoli scooped him up from Batumi for around €10m, and he has been in fine form since arriving in Italy. In 12 Serie A games, Kvaratskhelia has six goals and seven assists, while adding two goals and three assists in five Champions League matches.

A January sale has been ruled out, but if the club decide to cash-in on their shrewd piece of business, they could reportedly multiply their investment 10-fold.

TOP STORY – BREAKOUT NAPOLI YOUNGSTER SET TO COMMAND NINE-FIGURE FEE

According to Kvaratskhelia's agent Christian Emile in an interview with Fabrizio Romano, the Georgian sensation affectionately referred to as 'Kvaradona' by Napoli fans is one of the hottest names on the transfer market.

In the interview, reported by the London Evening Standard, Emile said there is "a zero per cent chance" he is sold in January as Napoli push for their first title since the 1989-90 season. 

However, he said "people are talking about €100m" when discussing Kvaratskhelia's value now, and if his form continues in this fashion the rest of the season, Emile added "he will reach €100m for sure".

The report names Liverpool and Chelsea as two of the key clubs known to have interest at this point.

ROUND-UP

– Mundo Deportivo is reporting Manchester City's Ilkay Gundogan – who is out of contract at the end of the season – is a target for Bayern Munich and Atletico Madrid. 

– According to The Daily Mail, Manchester United have made Borussia Dortmund's Jude Bellingham their top target.

– Eden Hazard could leave Real Madrid in January, per Mundo Deportivo, with Juventus named as a club interested in the 31-year-old.

– Media Foot is reporting United are "seriously considering" a move for 33-year-old Bayern Munich forward Eric Maxim Choupo-Moting, but they will not be making any significant purchases in January.

– According to L'Equipe, Lionel Messi does not want to leave Paris Saint-Germain without winning "a major trophy", and is considering extending his contract beyond this season.

Bayern Munich goalkeeper Manuel Neuer revealed he has previously been treated for skin cancer and underwent three operations on his face.

Neuer has joined forces with three-time tennis grand slam champion Angelique Kerber to release a skincare range called 'Newkee' and revealed the personal reasons for his involvement.

The 36-year-old had not previously disclosed the medical information, with the timeframe remaining unclear on the operation, though he was pictured last year playing with bandaging over his face.

"We both have a very personal history of skin diseases. In Angelique's case it's sun-related hyperpigmentation," the Germany veteran said in a press release launching the skincare range.

"In my case it's skin cancer on my face, which I've already had to have operated on three times."

Neuer has not featured for Bayern since October 8 due to a shoulder injury, but could be fit for the Bundesliga trip to Hertha Berlin on Saturday.

His return would prove a welcome boost for Germany, whose World Cup campaign starts against Japan in 21 days, as Hansi Flick's side aim for global glory in Qatar.

Bayern trail unlikely leaders Union Berlin by a point at the Bundesliga summit, with three games left to play before the break for the World Cup.

Sven Ulreich is enjoying one of those rare spells where everyone at Bayern Munich depends on his safe hands, and the loyal deputy to Manuel Neuer hopes this will not prove to be his final season at the club.

The 34-year-old goalkeeper – two years Neuer's junior – has played second fiddle to the Germany great throughout his time at Bayern.

This is Ulreich's seventh season with the Bundesliga champions, with his Bayern career broken up by one year away at Hamburg in 2020-21, where he spent a campaign as a first-team regular, albeit in Germany's second tier.

Ulreich was a Bayern mainstay in the 2017-18 season, but that was only because Neuer fractured a foot, keeping him out for almost the entire campaign.

The former Stuttgart number one has been a dutiful Bayern stand-in when called upon, as he has been in recent weeks with Neuer sidelined by a shoulder problem. Head coach Julian Nagelsmann last week said he has "a lot of trust" in his second choice.

On Tuesday in Milan, Ulreich was due to face Inter in the Champions League, making an eighth appearance of the season. Given Neuer is back in training and on the comeback trail, Ulreich may not get a ninth game for some time.

With Ulreich entering the final months of his Bayern contract, he is hoping there could be an extension in the offing. Recent first-team exposure should help his cause, with Bayern having won every game where he has featured so far this term, going into the Inter game.

"I've always said that I'm having fun and enjoying myself here," Ulreich told Sky Sport Germany. "I think we'll talk about it at some point. It's still too early, but I can very well imagine staying here.

"I'll be 35 next year. There won't be too much coming. But I'm not thinking about the end of my career just yet. I still plan to play for two years.

"As long as you're healthy and having fun, you should play on and you shouldn't say no. I'm currently healthy and fit."

Simone Inzaghi confirmed Romelu Lukaku will miss Inter's Champions League clash with Bayern Munich due to injury, but should recover before the World Cup.

Inter have already qualified for the knockout stages of UEFA's premier club competition after defeating Viktoria Plzen 4-0 on matchday five in Group C, subsequently eliminating Barcelona.

Belgium international Lukaku scored from the bench in the win over Plzen and was introduced as a substitute in Saturday's 3-0 win over Sampdoria, in which he aggravated a reoccurring left-hamstring injury.

While Inzaghi will be without the on-loan striker at Bayern on Tuesday, he suggested Lukaku should be fit before the World Cup, where Belgium start their campaign against Canada on November 23.

"He had a little problem with his scar [in his hamstring] in Saturday's match when he came on," Inzaghi said.

"There was a statement from the club, he will have to rest for a few days and then he will be re-evaluated at the weekend.

"It is a slowdown that was not needed, he was giving a lot in this period, we hope to be able to use him again before the [World Cup] break."

The trip to Allianz Arena may prove a step too soon for Marcelo Brozovic, too, though Inzaghi suggested the Croatia midfielder will be available for Sunday's crunch Serie A clash against Juventus.

"Brozovic we hope can return on Sunday, then [Danilo] D'Ambrosio is out and we won't have him until after the break," he added.

"We know what game we have on Sunday, I will change something but not too much. Today we did something on the pitch, but not too much. In my opinion the team is giving excellent responses."

Inzaghi hailed an "almost perfect" October after Inter made it seven games without defeat in all competitions, winning six of those, in what has been a transformation of fortunes for the Nerazzurri.

"Compared to September we are in better shape, the conditions of the players have improved," he continued.

"Tomorrow it will not count for the group, but it will be a match in a beautiful stadium, against one of the best in Europe.

"We want to have a serious, organised match, knowing that there will be difficulties, we find a very strong team, with a deep squad."

Manuel Neuer and Lucas Hernandez were back in Bayern Munich training on Monday, with their respective hopes of being fit for the World Cup seemingly receiving a boost.

Bayern captain Neuer had been struggling with a shoulder injury that forced him to miss six games, but he returned to goalkeeper training ahead of Tuesday's Champions League clash with Inter.

As recently as last week Nagelsmann did not want to commit to Neuer being ready to feature for Germany at the World Cup, saying he is not a "mystic".

But he appears hopeful of being able to call upon the 36-year-old away to Hertha Berlin on Saturday.

"We hope he'll be available again for the weekend. He came through training well and didn't show any reaction. But we'll have to wait and see," Nagelsmann told reporters.

Tuesday's game will also come too soon for Hernandez, not that the match has much riding on it – Bayern and Inter are already confirmed as Group C winners and runners-up respectively.

However, the France international is close to a return to action after suffering an adductor tear in September, with Monday seeing him take part in full team training.

Thomas Muller remains sidelined for the time being as well.

The Germany attacker has struggled lately with a hip issue, and Nagelsmann accepts he may not even be available to face Hertha.

"We'll reduce Thomas's workload this week and see how things are for the weekend," Nagelsmann said.

"But I'm leaning more towards him not being back at the weekend."

Matthijs de Ligt is a new name to be added to the injury list for Tuesday with a minor knee injury, leaving Nagelsmann's squad down to its bare bones as they look to end the group stage with maximum points.

"We will have to rotate a bit because we have some injured players who shouldn't play more than 45 minutes," he added.

"Nevertheless, we want to win the game. Anyone can show themselves. It's still a Champions League game and 18 points would be nice."

However, Nagelsmann suggested he will not give chances to youngsters who do not deserve an opportunity as he bemoaned the Under-19s' Youth League elimination after winning none of their first five group games.

"We'll take everyone but we'll see [on Tuesday] whether [youngsters] get chances," he continued.

"In general, I'm a friend of the fact that you have to earn success. You have to develop your genes, which is particularly important for young players at FC Bayern Munich.

"Success is part of a good education. You're doomed to win here at the club, so it's a shame we were eliminated so early in the Youth League.

"At FC Bayern, you always have to be the best in the youth teams so that the step-up to the pros isn't so big."

Toni Kroos has enjoyed one of the most garlanded careers in world football, but on Sunday he finally collected something rather less treasured than his many medals: a red card.

In his 634th competitive top-flight game at club level, Kroos was dismissed for the first time as Real Madrid were held 1-1 by Girona at the Santiago Bernabeu.

The Germany international had already been booked when he cynically fouled Aleix Garcia as Girona looked to break at speed in stoppage time.

That meant the 32-year-old had to go, with referee Mario Melero Lopez ordering him off.

Kroos played at the highest level in Germany for Bayern Munich and Bayer Leverkusen, where he had an 18-month loan spell early in his career.

After making his Bundesliga debut in 2007 and gradually developing into a Bayern star performer, Kroos was signed up by Madrid in July 2014, days after helping his national team win the World Cup.

He has won the Champions League five times, landed three Bundesliga titles and three LaLiga crowns, and added five Club World Cup wins.

That is just scratching the surface, with Kroos scoring 59 goals and adding 130 assists while prompting skilfully from midfield.

The 634-game total consists of all competitions, including Kroos playing 253 times in LaLiga, 173 games in the Bundesliga, and 132 matches in the Champions League.

Kroos was not entirely a stranger to referees over that time, but they had always held off showing him red. He had totted up 84 bookings before Lopez decided the moment had arrived for an early bath.

Atletico Madrid head coach Diego Simeone hailed Joao Felix for his impact in Saturday's 3-2 loss to Cadiz amid reports about transfer interest in the Portuguese forward.

Atleti, who were eliminated from the Champions League after a 2-2 draw with Bayer Leverkusen on Wednesday, conceded within the first minute against Cadiz and trailed 2-0 in the dying moments before 60th-minute substitute Joao Felix led a late rally.

The 22-year-old's 85th-minute over-head kick was deflected in by Luis Hernandez, before the Portuguese equalised with a rifled shot in the 89th minute. The goals were his first since April.

Joao Felix spurned a late header which Atleti would lament as Ruben Sobrino bundled the ball in from close range for a 98th-minute winner for Cadiz.

Despite the defeat, Simeone hailed Joao Felix for his impact, coming fresh from a report that claimed Atletico rejected a €100 million offer for the Portuguese from Bayern Munich in the off-season.

"Joao came in to do what he knows how to do, he did it very well," Simeone told DAZN.

"He scored a lucky goal but with the initiative to generate danger, he was the most dangerous of the forwards that were in the short time he entered.

"He scored a great goal, the second is a great goal. Hopefully he can keep that because in reality that is the player we all want."

Joao Felix, who has also been linked with a January transfer, has made 11 appearances in LaLiga this season, with five starts.

The defeat ended a tough week for Simeone, given their Champions League exit, with Club Brugge and Porto progressing in Group B. Atletico went behind in the first minute after Theo Bongonda's early strike which Simeone lamented.

"It was difficult at the start, after the blow the other day it was another blow," Simeone said. "After that we played a good first half, we had chances, we didn't take them.

"In the second half we went further behind at 2-0. Then the changes were important, Pablo Barrios coming on for his debut, Joao came on and played like we need him to play, Griezmann came on and gave us more calm in attack.

"We got into the game at 2-1, then the great goal from Joao for 2-2. We're in a moment when things aren't going our way."

Jamal Musiala scored his 10th goal of the season as ruthless Bayern Munich thrashed Mainz 6-2 in a pulsating Bundesliga contest to go top of the table.

It had been 57 days since Julian Nagelsmann's side were last at the summit, but they moved above Union Berlin with a sixth consecutive win on Saturday.

First-half goals from Serge Gnabry, the hugely impressive Musiala and Sadio Mane put them in command at the Allianz Arena, the Senegal forward finishing from the rebound after Robin Zentner saved his penalty.

Silvan Widmer pulled one back on the stroke of half-time just after Sven Ulreich kept out a Jonathan Burkardt spot-kick, but goals from Leon Goretzka and Mathys Tel put Bayern out of sight.

Marcus Ingvartsen capitalised on a terrible mistake from Ulreich to score Mainz's second goal, before the in-form Eric Maxim Choupo-Moting had the final stay with a late goal against his former club.

The champions took the lead in the fifth minute, Mane cutting the ball back and Gnabry finishing with his left foot from close range after a clever dummy from Musiala.

Musiala doubled their lead just before the half-hour mark, finishing off another slick move a clinical-right foot finish after exchanging passes with Choupo-Moting.

Burkardt rattled the crossbar and Jae-Sung Lee struck the post following up before Mane added a third Bayern goal, following up to tuck home after Zentner palmed his tame spot-kick back into his path.

Referee Felix Zwayer awarded that penalty following a VAR check for Alexander Hack's tackle on Mane and he pointed to the spot again after another check on the pitchside monitor, deeming that Ulreich had caught Anthony Caci when attempting to deal with a corner

Ulreich tipped Burkardt's spot-kick over the crossbar, but there was more drama when Widmer nodded in the resulting corner just before the break.

Benjamin Pavard replaced the injured Matthijs de Ligt for a second half that Mainz started brightly, but Choupo-Moting almost restored Bayern's three-goal lead when he hit an upright.

Goretzka duly got on the end of Mane's cross to nod in the Bavarian giants' fourth 58 after minutes and Tel came off the bench to got in on the act with a deflected strike 11 minutes from time.

Ulreich's awful pass gifted Ingvartsen the chance to slot home in the closing stages and there was still time for Choupo-Moting to round off the scoring with his right foot after Kingsley Coman picked him out.