Ronald Koeman promised Barcelona would "go with everything we have" to secure the LaLiga title on an evening when Atletico Madrid faltered again.
The trophy, and a domestic double, looked unlikely prospects as Barcelona stumbled through the opening months of the season.
Yet they will head into May with the Copa del Rey locked away in the trophy room and league glory could follow.
Long-time leaders Atletico have struggled without former Barcelona frontman Luis Suarez recently, and although he came off the bench in Sunday's clash with Athletic Bilbao, Diego Simeone's wobbling side suffered a 2-1 defeat.
It means that although Atletico still hold a two-point lead at the top, Barcelona and Real Madrid are the closest chasing sides, level on 71 points. Importantly, Barca have a game in hand over both their rivals.
The Camp Nou club's 2-1 win over Villarreal strengthened their championship case, with Real Madrid only able to draw 0-0 with Real Betis on Saturday.
Asked about the prospect of a league and cup double, Koeman said on Sunday: "I have never said that it is impossible, but when you have a distance of points and you are behind, you have to go game by game.
"We're in there. But the best way to win this league is to go game by game."
Speaking after Barcelona's win but before Atletico fell to their jolting defeat, Koeman praised his side, who have now gathered 46 points from a possible 51 since the turn of the year in LaLiga.
Of their last 24 clashes with Villarreal in LaLiga, Barca have won 18 times and drawn the other six, a staggeringly good record against one of Spain's better club sides.
"It is closer, but I don't know if it is very close," Koeman said of the title. "We have a track record of many victories. And what the team are doing is something very big, trying to win LaLiga as well.
"We know that if we win all six games we will be champions. We are going to go with everything we have to try to win LaLiga."
Atletico have lost two of their last five LaLiga games, showing fallibility at just the wrong time. They had previously lost just two of 44 league matches, including a strong finish to last season.
A Camp Nou clash between Atletico and Barcelona on May 8 is the standout fixture of the title run-in, and momentum can quickly turn.
Before that, Barca have games against Granada on Thursday and at Valencia on Sunday.
Koeman said it is "difficult to be 100 per cent" when games are coming so thick and fast.
But having come so far, making up so much ground when at one point qualifying for the Champions League looked to be in doubt, Barcelona are determined not to slow down.
As goalkeeper Marc-Andre ter Stegen put it on Instagram: "6 finals to go. We must be ready for Thursday."
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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