Mikel Arteta was unsure when Pierre-Emerick Aubameyang would return as he reflected on a "really sad" FA Cup elimination for Arsenal.
The Gunners went down to a 1-0 defeat at Southampton on Saturday, their hopes of retaining the trophy ended in the fourth round.
Arsenal played without captain Aubameyang, who had to leave the team in the hours before kick-off for personal reasons.
Amid reports attacking midfielder Martin Odegaard is set to join from Real Madrid, Arteta expressed regret at his side's exit.
"Really sad to be out of the competition," he said to BT Sport. "Disappointed to be out and the way we conceded.
"We are looking in the market and will see what we can do."
The teams meet again at St Mary's on Tuesday for a Premier League clash and Arteta is unsure whether Aubameyang will be back.
"I don't know, he needs to address that issue and see how it evolves," the Arsenal boss said at his post-match news conference.
"We are here, we will have to support him. He needs to take the time that is needed because that is a priority at the moment."
Gabriel Magalhaes' first-half own goal settled a scrappy contest where Arteta felt Arsenal had improved after the break.
Arteta added: "We had issues in the first half and unforced errors as a result of the high-press they do.
"In the second half we had two or three big chances but not enough. It was an even game.
"In the first half they won a lot of second balls. In the second half we added more quality. We became more dominant and created chances but it wasn't enough."
Arsenal have conceded four own goals in all competitions this season.
Opta statistics show this is more than any other Premier League side and the most they have conceded in a single season since 2015-16 (five).
Asked if Gabriel had been rusty, Arteta said: "Maybe. He hasn't played enough minutes in the last month or so since he had the Covid.
"He had to stay at home, he hasn't trained as much as we would like him to. He is a player that has done so well since he has joined us. Credit to Southampton because they make it really hard for you."
Southampton boss Ralph Hasenhuttl was impressed with the way his team played, though suggested it had not been a perfect display.
"It was a good team performance," he said. "In general our work without the ball was good.
"We had in the first half more punch and more power. In the second half it's normal they have a lift. We must make the second goal.
"We made one or two chances - Shane Long should have got a penalty. We had early ball wins, but our last decision-making was not always the best."
Arsenal have now failed to make the fifth round of the FA Cup in three of the last four seasons.
Michail Antonio felt officials were against West Ham after European exit
Michail Antonio felt West Ham were up against 14 players as they bowed out of the Europa League to Bayer Leverkusen.
Antonio’s early header gave the Hammers hope of overturning a 2-0 first-leg deficit and inflicting a first defeat of the season on Xabi Alonso’s new Bundesliga champions.
But the bustling striker claimed he did not get a decision all night from card-happy Spanish referee Jose Maria Sanchez and his two assistants.
“It doesn’t feel like you’re playing against 11 men, it feels like you’re playing against 13 or 14 including the two linos,” Antonio told TNT Sports.
“You just have to keep pushing and try and make the decisions go your way. And they just weren’t. We had to keep playing our way and keep being professional.”
West Ham pushed gamely for a second goal to take the tie to extra-time, but as they inevitably flagged Leverkusen substitute Jeremie Frimpong scored with a deflected shot in the last minute to make it 1-1 on the night and 3-1 on aggregate.
It was a valiant effort but ultimately a sad end to another European adventure for last season’s Conference League winners.
“We’re very proud of ourselves, to achieve what we’ve achieved over the last few years is incredible,” added Antonio.
“Three back-to-back years in European quarter-finals I would never have thought that. We were a yo-yo team, fighting relegation, then into Europe.”
Sanchez booked 11 players and sent off West Ham coach Billy McKinlay, and Sebastian Parrilla from Leverkusen’s staff after a touchline altercation.
Asked if that skirmish had anything to do with some bad-tempered exchanges between the benches in last week’s first leg, Alonso said with a grin: “I wouldn’t say no.”
Hammers boss David Moyes was not keen to be drawn on the officiating, but he did say: “I watch a lot of Spanish football but if that’s the way it is you wouldn’t want to watch too many Spanish matches.”
On his side’s performance, he added: “It was a brilliant team performance, I have to say over the two games.
“We played a really good team and we had chances to be two or three up. I couldn’t fault the players at all. If I was going out of Europe I wanted to go out like that.”
In the first half Leverkusen looked as though they may have celebrated their first Bundesliga crown on Sunday a little too much, and Alonso admitted they needed to improve after the break.
“For sure it was a thrilling game,” he said. “Two different halves. First half we knew West Ham would come with high intensity and we were not comfortable with that.
“After they scored one we were lucky not to concede a second one. But we showed character in the second half and the substitutes had a good impact. It was a lesson for us.”
Jurgen Klopp accepts lack of threat cost Liverpool dear in European exit
Liverpool manager Jurgen Klopp accepted their lack of goal threat failed to put enough pressure on Atalanta to help turn their Europa League quarter-final back in their favour.
Mohamed Salah’s seventh-minute penalty had raised hopes of a Barcelona 2019-style comeback but the Egypt international missed a relatively straightforward lob to make it 2-0 towards the end of the first half and they faded badly after the break as they exited the competition 3-1 on aggregate.
That meant for only the third time in the 21st century, England have no teams in the semi-finals of the Champions League or Europa League/UEFA Cup.
“We didn’t lose the tie tonight, we lost it at home,” Klopp said after a 3-0 first-leg defeat proved decisive.
“It’s very easy to congratulate Atalanta because they deserved to go through. When you win a tie against us 3-1 in especially this way you deserve it absolutely.
“But I loved our game, especially the start. I loved the commitment, desire and power we developed in this game but it was clear we had better score from time to time otherwise it could be tricky over 90 minutes.
“The second goal could have helped a little bit. We have to create a little bit more than we did in the first half as it’s clear you need a result to help destabilise the opponent.
“If you have a second goal it’s a tricky one as the next goal is extra time but we didn’t get to that point and we will never really know how that would have looked.
“Disappointed we didn’t go through but not frustrated or angry. If you don’t deserve it, it’s all good.”
Salah has looked well short of his clinical best since returning from almost two months out with a hamstring problem.
Even though he has scored six in 11 game since he came back two of those have been penalties and he is squandering more chances he would normally be expected to take.
“I’m not particularly concerned. That’s what strikers do. That’s how it it is. We have to go through it, he has to go through it,” added Klopp.
“He is one of most experienced players in the squad. That’s pretty much all.
“It’s not that Mo didn’t miss chances before in his life, that’s part of the game. The penalty was super convincing, a super penalty then the next chance that was unlucky, but it’s not the first time has has missed chances like that.
“I won’t make a big story of it. I’m not particularly concerned.”
Liverpool exit Europa League despite win at Atalanta
Liverpool crashed out of the Europa League after they failed to turn around their 3-0 first-leg defeat to Atalanta despite winning 1-0 at Gewiss Stadium.
Jurgen Klopp’s men took the lead from the spot in the seventh minute through Mohamed Salah but could not find the goals needed as they fell to a 3-1 aggregate loss in the quarter-finals.
West Ham were knocked out by Bundesliga champions Bayer Leverkusen at London Stadium, also going out 3-1 on aggregate.
The Hammers gave themselves hope, both in the tie and of inflicting a first defeat of the season on Leverkusen, courtesy of Michail Antonio’s first-half goal.
But it was not enough as Leverkusen scored late on through Jeremie Frimpong.
Roma held off AC Milan to advance to the semi-finals.
Daniele De Rossi’s side, who won the first leg 1-0, scored two quickfire goals through Gianluca Mancini and Paulo Dybala to strengthen their advantage.
Despite Mehmet Zeki Çelik’s red card for a late challenge on Rafael Leao and Matteo Gabbia pulling one back in the 85th minute, the hosts managed to see out the match.
Marseille had to rely on penalties to claim their last-eight win over Benfica.
Benfica went to Stade Velodrome with a 2-1 advantage.
Faris Moumbagna opened the scoring for the hosts but both defences proved to be stubborn as the match went the distance after extra-time.
Antonio Silva and Angel Di Maria missed from 12 yards before Luis Henrique scored the decisive spot-kick to send the French club through.
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