Lionel Messi is bidding to score at home in the Champions League for the first time this season as Barcelona take on Borussia Dortmund.

The Argentina international fired his latest blank in the 0-0 draw with Slavia Prague three weeks ago, leaving his side with work to do if they are to progress to the last 16.

Barca will be through if they beat Dortmund or if they draw and Inter fall to defeat at Slavia in the other Group F contest taking place on Wednesday.

Elsewhere, holders Liverpool host Napoli at Anfield aiming to avenge a 2-0 defeat from the reverse fixture, while Chelsea will reach the knockout stages with victory against Valencia.

Below, we have highlighted the key data ahead of Wednesday's eight matches.

Barcelona v Borussia Dortmund

12 - Barcelona forward Messi scored with his last shot at Camp Nou in the 2018-19 Champions League season. He has attempted 12 without success this term, failing to score in both home matches. Should he not to score in this game, it would be first time since October 2011 he has failed to find the back of the net in three consecutive home games in the competition (a run of four).

4 - Borussia Dortmund's Achraf Hakimi has scored four Champions League goals this season – only one Moroccan player has ever netted more in a single campaign, with Marouane Chamakh scoring five for Bordeaux in the 2009-10 campaign.

Slavia Prague v Inter

3,119 - Slavia Prague have given 3,119 minutes to Czech players in the Champions League this season – the most by players of the nation of the club they are representing in the competition this campaign.

3 - Lautaro Martinez has scored in his last three Champions League appearances for Inter. He could become the fifth Argentinian to score in four consecutively, after Hernan Crespo (2002), Lionel Messi (six occasions), Sergio Aguero (2019) and Ezequiel Lavezzi (2013).

Liverpool v Napoli

2 - Liverpool's Alex Oxlade-Chamberlain has scored in his last two Champions League appearances – the only Englishman to score in three consecutive matches for the Reds is Steven Gerrard (five in a row in 2007-08).

3 - Napoli head coach Carlo Ancelotti was the last manager to win an away Champions League match at Anfield, leading Real Madrid to a 3-0 victory in October 2014. No coach has won more away Champions League games in England than Ancelotti (three – level with Jose Mourinho and Massimiliano Allegri).

Genk v Salzburg

0 - Genk remain winless in all 16 of their Champions League matches (W0 D8 L8). It is the fifth longest winless run in the competition's history and the longest since December 2017 (Maribor – 17 matches).

5 - Salzburg striker Erling Haaland will become just the third player to score in his first five Champions League appearances if he scores in this match. The two to do so are Alessandro Del Piero (1995, Juventus) and Diego Costa (2013-14, Atletico Madrid).

Valencia v Chelsea

3 - Valencia have won three of their last four home Champions League games (W3 D0 L1), having lost four of their previous five (W1 D0 L4).

14 - Chelsea striker Tammy Abraham has had more shots than any other Chelsea player in the Champions League this season (14). However, he has found the net with just one of those shots and has scored as many own goals as he has goals (one).

Lille v Ajax

10 - Lille are winless in 10 home Champions League matches (W0 D4 L6). Only two teams have ever had longer home winless runs – Spartak Moscow (11 between 2001 and 2006) and Steaua Bucharest (13 between 1996 and 2013).

10 - Ajax's Hakim Ziyech has been involved in 10 goals in his last 12 Champions League appearances (four goals, six assists). The Moroccan has either scored or assisted in each of his last six away games in the competition (two goals, five assists).

RB Leipzig v Benfica

30 - RB Leipzig are one of only two teams yet to give a single minute to a player aged 30+ in the Champions League this season, along with Genk. In his 10 games as coach in the competition, Julian Nagelsmann has only used one player aged 30 or older – Hungarian striker Adam Szalai for Hoffenheim last season.

10 - Benfica have lost all 10 of their away matches in Germany in the European Cup/Champions League, facing six different teams without success.

Zenit v Lyon 

2 - Zenit have lost two of their last three home European matches (excluding qualifiers) – one more than they had lost in their previous 21 home games (W18 D2 L1).

4 - Lyon's Memphis Depay has scored in all four Champions League matches this season. No Lyon player has ever scored in five consecutive appearances, while only three Dutchmen have scored in five or more – Roy Makaay (2002), Ruud van Nistelrooy (2002, 2003 and 2007) and Arjen Robben (2013).

Tottenham midfielder Dele Alli was unsurprised by the "amazing" Harry Kane breaking a Champions League record on Tuesday.

Kane scored a brace in Spurs' come-from-behind 4-2 win over Olympiacos, setting a record in the process.

The England international became the fastest player to score 20 Champions League goals, reaching the tally in just 24 games – two quicker than Juventus great Alessandro Del Piero.

Alli was unsurprised by his team-mate's efforts, hailing the 26-year-old forward.

"It's amazing," he said. "Obviously we've been playing together for a few years now, he's an amazing guy, top player so he deserves all the credit he gets.

"I'm not surprised he broke another record."

Alli was also on the scoresheet as Jose Mourinho's men came from behind to secure their place in the knockout round from Group B.

The 23-year-old said Spurs knew they had the talent to turn the clash around.

"I think just character and belief. We know the quality we have in the squad," Alli said.

"When you're performing badly, you want to turn it around. Personally I felt like I was at fault for the second goal.

"Getting the goal just before half-time gives us momentum going into the second half and belief. I think we showed our quality in the second half."

Tottenham are in action again at home to Bournemouth on Saturday.

Diego Simeone blamed Atletico Madrid's scoring woes on wasteful finishing rather than chance creation following the Champions League loss to Juventus.

The Rojiblancos drew a blank in Turin as Paulo Dybala's stunning free-kick before half-time wrapped up a 1-0 win and top spot in Group D for the Serie A side.

Alvaro Morata squandered a good late opportunity, albeit from a seemingly offside position, while Thomas Partey and Saul Niguez missed decent chances as the visitors hit the target with two of their 15 shots.

Atletico have now been restricted to six goals in five Champions League games and are the least prolific of all bar one team among LaLiga's top 12.

Simeone said: "I think we played a good game against a really great team.

"I think we are lacking precision in the forward areas as we are generating enough dangerous situations to score goals. We worked very well tactically."

He continued: "We need to work on improving our numbers, which are bad.

"Obviously we all need to work more, have patience and do our best in order to generate more chances.

"Vitolo and Morata put in a great effort and Felipe played an extraordinary game. We improved as the game went on. In the first half we tried to be strong at the back and then play on the break.

"We did well as [Juve] hardly created chances in the first half, except the goal, and in the second half we also improved as the period went on but could not score, which is the most important thing in football."

Atletico splashed €126million on Joao Felix in the close season but have struggled to replace Antoine Griezmann's goals.

The loss of Diego Costa for up to three months with a neck injury has further depleted Simeone's attacking stocks, but the Argentine head coach would not commit to further spending in January.

"I work with the players I have," he said.

"I'm doing my best in order to make them better and I will not change that mentality. Then, we will see what decisions will be made regarding the needs the team have."

Jose Mourinho refused to reveal his half-time team talk after Tottenham's Champions League comeback, instead urging people to wait and buy the Amazon documentary.

Tottenham made it two wins from two games under new boss Mourinho following Tuesday's stunning 4-2 victory over Olympiacos in London.

Spurs overturned a 2-0 deficit thanks to Harry Kane's brace and goals from Dele Alli and Serge Aurier as last season's finalists booked their spot in the Champions League round of 16.

Amazon Prime Video are filming a behind-the-scenes documentary about Tottenham this season and head coach Mourinho, who replaced Mauricio Pochettino last week, is keeping a lid on things ahead of its eventual release.

"I think if you wait a few months and you buy the Amazon movie you will find out," Mourinho told reporters when asked about his message to the Spurs squad at half-time. "For me it had to be a soft version of myself because it was a bit of a surprise to me.

"I felt that the players' self-esteem and self-confidence, they were playing at home with not the best results, probably with the Bayern [Munich] game behind their thoughts. I felt that they were in need of some love at that time and not The Critical One. I felt there needed to be more of an emotional balance.

"After that we talked about a few tactical details, tactical position adjustments but it was more about their confidence, their difficult situation and to go for it."

Mourinho's tenure opened with a 3-2 Premier League win over London rivals West Ham last week – the Hammers scoring two late goals as Tottenham dominated away from home.

Tuesday was Mourinho's first match in charge at Tottenham Hotspur Stadium but the former Manchester United manager said: "I think again that it's not about me, it's about the team. I just want to help, the fans help, the ball boy helps. Everybody who loves Spurs helped. The players are the most important thing.

"Of course my feeling was great, especially because it was one of those matches where I had to play. You know some matches you play before the match in the way you prepare the team. You work, you train, you prepare and then the game starts and the direction in the game is not very important.

"In other matches you have to play and I had to play. Apart from an awful feeling in relation to Eric [Dier, substituted in the first half], apart from that awful feeling everything was great for me and I think it was victory 80 for me in the Champions League. So let's hope for victory 81."

Thomas Tuchel said he benched Neymar for the player's own good against Real Madrid and did not fear upsetting the Paris Saint-Germain star.

Neymar, a starter against Lille on Friday, was introduced at half-time of a rollicking 2-2 Champions League draw in Madrid on Tuesday. 

PSG trailed to Karim Benzema's opener when the Brazilian entered the game and fell further behind when the Madrid striker nodded in Marcelo's cross, before Kylian Mbappe and Pablo Sarabia struck in quick succession to force a share of the spoils.

Tuchel admitted ahead of the Madrid showdown that Neymar could at times be tough to manage but insisted his reduced role at the Santiago Bernabeu was a direct result of his recent hamstring injury.

"No, I'm not afraid [of the ramifications], I don't think we are going to lose Neymar," the PSG boss said.

"We have a connection, we are honest. I talked to him and told him that I would rather he play in the second half and start on the bench. We did the same thing with Kylian away to Galatasaray.

"He's been absent for six weeks, he only played one game before this one and for me it was not worth taking that risk.

"Every month he missed a few days. I made the decision for him, for his health."

Despite being outplayed for 80 minutes in the Spanish capital, PSG did enough to confirm top spot in Group A.

Visitors PSG had goalkeeper Keylor Navas to thank for a series of excellent stops that prevented his former employers from taking a decisive lead.

Tuchel said: "Real were the better team for a long time. We played too complicated, not quick enough, not simple enough, not with confidence. Real played with a lot of confidence.

"They showed that this is a team that won the Champions League three times in a row.

"We had an extraordinary goalkeeper with Keylor Navas. We were lucky, it's not forbidden. After the goal, we were freer.

"There are some positive things to remember. The mentality at the end, the quality of the guys who came on, Ney and Pablo and [Julian] Draxler made the difference. We have 13 points from five games."

"What the f*** are you shooting from over there?" was Maurizio Sarri's reaction to Paulo Dybala's memorable free-kick for Juventus in the Champions League.

Dybala scored a stunning set-piece against Atletico Madrid as Juve secured top spot in Group D with Tuesday's 1-0 victory in Turin.

From an acute angle on the right side of the penalty box, Dybala somehow beat Atletico goalkeeper Jan Oblak in first-half stoppage time.

Speaking to reporters post-game, Juve head coach Sarri said: "Dybala scored a goal that nobody could have advised him to do.

"The first thing that a coach says in that situation is: 'What the f*** are you shooting from over there?' And therefore what he did was extraordinary.

"The applause was owed to him, for the performance but also for the technical skill which was extraordinary."

While Dybala was the hero again for Juve, it was another frustrating night for superstar Cristiano Ronaldo.

Having missed last week's victory away to Atalanta due to his troublesome knee, Ronaldo returned to the line-up but he appeared to struggle against Atletico.

Asked if Ronaldo is cut off from the game due to the team's style of play, Sarri told reporters: "No, there was no problem with Ronaldo.

"The problem was the way we were occupying spaces. In the first half Paulo was often playing far away from the goal, Cristiano was not playing in the centre and therefore we were never occupying the central spaces. We could have done this more with one of the two alternatively, when Paulo was going for the ball Cristiano could have played more in the centre and when Cristiano was out Dybala could have gone less for the ball.

"Otherwise we could have exploited that space with [Aaron] Ramsey, therefore we had some problem occupying spaces, rather than because we were cutting off players from the game."

Pep Guardiola turned focus to the Premier League title race after Manchester City booked their place in the Champions League last 16 with a 1-1 draw against Shakhtar Donetsk.

A point was enough for the English champions to advance through as Group C winners with a game to spare thanks to Dinamo Zagreb's defeat to Atalanta.

City struggled to get going at the Etihad Stadium but took the lead through Ilkay Gundogan 11 minutes into the second half, only for substitute Manor Solomon to equalise soon after.

Despite his side's underwhelming display, making it back-to-back European draws, Guardiola was ultimately pleased to see his side achieve their aim of progression.

"We qualify and we played well in the second half," Guardiola, who had won nine of his previous 12 matches against Shakhtar, told BT Sport.

"The second half was better than the first. We conceded only a few counter-attacks. 

"In the first half we were too hurried in our play and gave away possession but in the second half we were more measured and improved.

"I've played against Shakhtar Donetsk many times and they always have quality players. In general, we created chances but the draw was enough in the end. 

"Now we have one competition already done, and our focus will be the Premier League, until we arrive in the cups. The target was to qualify and we have done it."

City have advanced out of the group phase in seven successive seasons, four of those under Guardiola, and the Catalan coach admitted the club have come a long way.

"This process, where we are right now and where we were a decade ago... seven years in a row means you have to qualify seven times and be there and go through," he added at his post-match news conference.

"We will see in which conditions we arrive in the knockout rounds, but now it is time to focus on the Premier League."

Guardiola's side are unbeaten in 10 group-stage games since October 2018 and head to Zagreb next month.

The two-time Champions League-winning coach suggested he will not play a weakened team in Croatia, however, as he does not want to devalue the competition.

"Of course I will take a look but we are going to have enough players. We will use the first team," he said. "The Champions League is prestigious. 

"We are going to travel with the intention to win. For respect for Shakhtar and Atalanta we have to do it."

The draw leaves Ukrainian champions Shakhtar second in Group C, a point better off than Dinamo and two in front of next opponents Atalanta.

Head coach Luis Castro was pleased with the result, which stretches his side's unbeaten away run in the competition to four games and leaves them well positioned to qualify.

"To be honest, any result I accept normally," he said. "The game is never evaluated by how many corners or fouls or opportunities there were. 

"In every game there are certain statistics we can look at. We could have won, City could have won but the result was 1-1.

"In principle, as we expected, the last game of City will be against Dinamo Zagreb. We knew if we lost we could be out of the competition. 

"We are happy with both results and everything will be decided by the last game. We will see."

Marten De Roon said Atalanta have finally shown they can compete at Champions League level having been a "bit of a joke" in their opening three matches.

Luis Muriel and Alejandro Gomez goals handed Atalanta their first Champions League victory as the Serie A side kept their slim last-16 hopes alive with a deserved 2-0 win over Dinamo Zagreb on Tuesday.

Gian Piero Gasperini's Atalanta now find themselves in a three-way battle for the second qualification spot behind Group C winners Manchester City heading into matchday six.

"After the first three matches we looked like a bit of a joke in the Champions League, but after tonight we showed we're at this level," midfielder De Roon said.

Atalanta head coach Gasperini added: "It's the night we wanted. Gomez's goal came after many missed chances and gave us the boost we needed. Now we believe we can progress."

The Italian outfit remain bottom of Group C and must beat Shakhtar Donetsk in the final game while hoping Dinamo fail to win against Pep Guardiola's Premier League champions.

Atalanta midfielder Remo Freuler said: "We believe we can progress, of course. We need a win to stay in Europe – and, if we're lucky, the Champions League."

It was a disappointing evening for their Croatian opponents, who had thrashed Atalanta 4-0 in the reverse fixture.

"Sometimes you have to admit that your opponents were better and Atalanta were simply better than us tonight," coach Nenad Bjelica said.

"We had some chances when we were one goal behind but didn't score from them. We could have been better in every segment of the game. We let them make chances and we didn't play fast and simple enough.

"They deserved it tonight. They played like we did in the game in Zagreb. Now we have nothing to lose. In front of our fans, anything can happen."

Kylian Mbappe is "100 per cent" staying at Paris Saint-Germain amid links to Real Madrid insisted sporting director Leonardo, who revealed contract negotiations are progressing.

PSG star Mbappe scored as the visitors salvaged a dramatic 2-2 draw away to Madrid in the Champions League on Tuesday.

Madrid head coach Zinedine Zidane reaffirmed his admiration for Mbappe on the eve of the Group A blockbuster, saying: "I am already in love with him".

Mbappe made an impact against his reported suitors at the Santiago Bernabeu, where PSG sealed top spot ahead of LaLiga giants Madrid.

Asked about Mbappe's future, Leonardo told RMC: "Mbappe will stay here, 100 per cent. He is a PSG player. The rest is the rest."

"We will see. We are advancing, advancing slowly but we are advancing," Leonardo added when asked about a contract extension.

France international Mbappe dazzled last season with 39 goals in all competitions as PSG won the Ligue 1 title.

This term, World Cup winner Mbappe has 10 goals across all competitions – including five in Ligue 1 for Thomas Tuchel's side.

There were enough sub-plots for Real Madrid's Champions League clash with Paris Saint-Germain to be turned into a feature-length film before a ball had even been kicked at the Santiago Bernabeu.

By the end of 90 breathless, pulsating and sheer joy-inducing minutes there were enough storylines to make a franchise that could rival even the lucrative Marvel series.

For 81 of those, Zinedine Zidane and his expensively assembled squad of Galacticos were almost tactically flawless.

The decision to hand Isco a first start in six weeks appeared truly inspired. The short, sharp passing in a midfield trio alongside Federico Valverde and Casemiro had PSG – who had dominated the same opponents 3-0 on matchday one – chasing white shirts with about as much success as an excitable dog longing to reach its tail.

If that problem wasn't big enough then the one caused by Eden Hazard would have given PSG's defence and head coach Thomas Tuchel nightmare-filled sleep for the foreseeable future.

Injury woes early in his Madrid career have meant it has taken Hazard a little while to get up to speed in the Spanish capital.

But for 70 minutes here, Hazard was utterly joyous – try as you might, taking your eyes of this Rolls Royce of a footballer was an impossible task.

Hazard was full of the sort of invention, creativity and genius nuances that convinced Madrid to part with over €100million to prise him from Chelsea.

It was as much a blow to the neutrals watching when Hazard was helped off the pitch following a strong challenge from Belgium team-mate Thomas Meunier as it was to Zidane and his Madrid team-mates.

That Hazard departing the pitch through injury became almost a footnote tells a story in itself about this classic of the Champions League genre.

Karim Benzema's second goal in the 79th minute should have been the cherry atop of a scrumptious cake for Madrid, who despite Zidane's protestations to the contrary would have had revenge in mind.

Granted it had taken a helping hand from the VAR, another of football's most divisive modern issues, to get that point.

The decision to overturn a red card for Thibaut Courtois – who rashly wiped out Mauro Icardi – for the softest of fouls from Idrissa Gueye on Marcelo earlier in the move appeared certain to dominate the narrative.

Even accounting for that let-off, it was another side-note in a game swimming with them that kept Madrid at bay.

Keylor Navas, who left for PSG having fallen behind Courtois in the goalkeeper pecking order at Madrid, was in inspired form – Benzema and Isco particularly left frustrated by his brilliance. That he was received so well by the home crowd speaks volumes of his contribution over five trophy-laden years at the Bernabeu.

Indeed it was his heroics that allowed Kylian Mbappe – the man so desired by Los Blancos fans – to take an almighty spanner and throw it directly into the works.

Those familiar with the story know Madrid have not exactly been quiet in expressing their admiration for the World Cup winner. Heck, even this week Zidane publicly declared his love for the rapid forward, who it is hard to imagine will not one day don the famous white of Madrid.

That love may have dwindled a little when Mbappe capitalised on a lack of communication between Courtois and Raphael Varane to hand PSG a precious lifeline.

Two minutes later, the irony will not have been lost on Zidane that the man to deny Madrid what would, in truth, have been a deserved victory to keep their hopes of finishing top of Group A alive was Pablo Sarabia – a player who graduated through the youth ranks at the Bernabeu.

Remarkably, only the width of a post denied one final twist and one so tantalisingly delicious it would not have been out of place in an M. Night Shyamalan film.

Gareth Bale, a man much derided by his own fans and the Spanish media for his 'WALES. GOLF. MADRID. IN THAT ORDER' banner celebration after Wales qualified for Euro 2020, stood poised over a free-kick 30 yards from goal.

This particular narrative only narrowly failed to play out. Had it done so the reactions would have been incredulity, shock and uncontrollable laughter. In that order.

When the dust settles, Zidane will analyse with forensic scrutiny Madrid's failure to first kill the contest through the numerous chances they created, and second to manage the game when two up with 10 minutes to go.

But for anyone without an affiliation for either of these two giants of European football, the only thing to do was sit back, jaws gaping, as the credits rolled on a match worthy of any big screen.

Zinedine Zidane admitted he was worried about Eden Hazard's ankle injury suffered in Real Madrid's 2-2 draw with Paris Saint-Germain.

Hazard was substituted in the second half at the Santiago Bernabeu, where Madrid gave up a 2-0 lead in the Champions League on Tuesday.

Zidane, whose team are guaranteed to finish second in Group A, is concerned about the injury blow.

"Yes, it's a worry," the Madrid coach told Movistar.

At his news conference, Zidane added: "It is more than a simple blow, but I hope it is less. I can't say right now.

"They have now gone to do tests and we will see."

A brace from Karim Benzema had put Madrid on track for victory with just 11 minutes remaining.

However, Kylian Mbappe and Pablo Sarabia scored in the space of two minutes to earn PSG a draw.

While unhappy with the result, Zidane said the performance from Madrid was pleasing.

"It has been a great match of the team. We keep growing. You have to be happy with the game," he said.

"Then with the result you cannot be happy but nothing happens. You have to be happy with what we did for 80 or 85 minutes."

Robert Lewandowski claimed to be addicted to scoring goals after he led Bayern Munich to a 6-0 rout over Red Star Belgrade in the Champions League.

Lewandowski was at his awe-inspiring best on Tuesday as he scored four times in little more than 14 second-half minutes at Rajko Mitic Stadium.

His efforts inspired a fourth successive win, with 16 goals scored and none conceded, for interim boss Hans-Dieter Flick – the best start of any Bayern coach.

The Poland international's quadruple was also the fastest in the history of the Champions League, as Lewandowski joined Lionel Messi as the only players to score four goals in a game in the competition on more than one occasion.

And according to the 31-year-old, scoring goals is an addiction.

"I have to confess... I am addicted to scoring goals," Lewandowski – who has already scored 27 times from 20 appearances in all competitions so far this season – tweeted.

He added to Sky Sport: "The most important thing is that we played well, defensively and offensively, we have fun, no matter who plays, we follow our plan.

"I'm also happy if I do not score and we win nevertheless."

Lewandowski's stunning second-half show came after he had seen a superb strike ruled out by the VAR for a handball from Corentin Tolisso before the break.

That followed Leon Goretzka's opener, while Tolisso rounded off the scoring late on.

"Robert is in such good form," said Flick, who is reportedly in line to remain as Bayern's coach until at least the end of the season, in his post-match news conference. 

"He is professional and works really hard and got his rewards tonight. He's a really important player for us."

With top spot in Group B now secured, Bayern face Jose Mourinho's Tottenham, who are also through after a 4-2 comeback win over Olympiacos, in their next Champions League outing.

Jose Mourinho was thrilled by "an important assist" in Tottenham's 4-2 comeback win against Olympiacos, but it was not provided by one of his players – rather a Spurs ball boy.

Tottenham endured a woeful start to Mourinho's first home match at the helm as they found themselves 2-0 down inside 19 minutes, with Youssef El-Arabi and Ruben Semedo putting the away side in charge.

But Dele Alli pulled one back just before half-time and then, shortly after the break, came Harry Kane's equaliser.

The goal might not have been possible were it not for the quick thinking of a ball boy, however, as he swiftly got the ball back to Serge Aurier for a throw-in while Olympiacos' defence was out of shape, and Lucas Moura subsequently set up Kane.

Aurier then got a stunning goal of his own before Kane wrapped the win up, but Mourinho's focus was on the preparedness of the child rather than his players.

"To do that, you have to be a very good ball boy," Mourinho, who embraced the boy after the goal, told reporters. "I was, between 10 and 16 years old, a very good ball boy and he was a very good ball boy.

"He was reading the game, understanding the game and wasn't looking at the stands. He made an important assist.

"I wanted to invite him to the dressing room to celebrate with the players, but he had disappeared."

The win for Spurs ensured they head into their final group outing against Bayern Munich having already made sure of progression to the next stage.

Cristiano Ronaldo continues to be troubled by knee pain, with Juventus head coach Maurizio Sarri to discuss the injury with his star forward.

Ronaldo returned to the Juve side for Tuesday's 1-0 Champions League win at home to Atletico Madrid after missing a weekend victory away to Atalanta in Serie A.

The Portugal international appeared to struggle at times as Paulo Dybala's stunning free-kick ensured the Bianconeri will finish top of Group D with a game to spare.

Ronaldo was substituted in each of Juve's two league games prior to the international break, and Sarri accepts the 34-year-old's fitness must be managed.

"I haven't spoken to him yet about the pain in his knee," Sarri told Sky Sport Italia after Ronaldo completed the full 90 minutes. 

"But he looked to be in good shape, as in the final stages he was tracking back, fighting hard and helping out in defence.

"Dybala is world class, in a very positive period of form, so right now he is making the difference."

Though Juve maintained their momentum with another victory, Sarri was left frustrated with aspects of their performance against Atletico.

"We used up a lot of energy this evening, as is inevitable in the Champions League," he added. 

"I think we did very well but, like the Atalanta match at the weekend, we had to fight very hard to achieve the victory.

"It was above all a great first half, and we built on that. We tend to struggle more in Serie A to pass it around quickly.

"Perhaps there is more motivation for us in the Champions League, but that is a mistake, because we have to play this style of football in every tournament.

"I was angry in the second half, as we gave the ball away cheaply. The sensation was that, just like Atalanta, we allowed them to cross too much.

"Maybe we need to improve the intensity with which we close down these crosses and passes in wide areas."

Jose Mourinho apologised to Eric Dier following the midfielder's first-half substitution in Tottenham's eventual 4-2 home win over Olympiacos in the Champions League.

Dier was replaced by Christian Eriksen 29 minutes into Tuesday's Group B fixture with Tottenham trailing 2-0, Youssef El-Arabi and Ruben Semedo stunning the home side in London.

The early change ultimately paid off as last season's runners-up stormed back to pick up the three points required to reach the Champions League round of 16.

But head coach Mourinho, taking charge of his second game since replacing Mauricio Pochettino last week, was quick to publicly apologise to Dier for sacrificing him inside the opening half an hour.

"The first thing I did in the dressing room is apologise to Eric Dier. It is never easy for a player but not for the coaching staff either," he told BT Sport. 

"It was for the team and we needed a different solution. We were losing 2-0, they were closing really well and I needed a second man with Dele Alli to come into the pockets. It was between Dier and Harry Winks but a hard decision. 

"They understand, Eric understands but the reality it is never a easy and to make it clear, it was about the team not individuals. I thought about taking out one of the centre-backs and putting Eric in defence."

A poor error from Yassine Meriah gifted Alli a goal to give Tottenham a route back into the game before half-time and they produced an improved display in the second half.

Harry Kane scored twice, either side of Serge Aurier's strike, as Premier League outfit Tottenham reached the last 16 for the third season running.

"We have qualified for the next round, that is the important thing for all of us at the club and the fans," Mourinho said. "It was hard, they are a good team, very well organised and they attacked our self-esteem and self-confidence. 

"I did not expect our boys to feel this pressure at home and they have not had the best results in the last few months."

Asked about what he told his players at the interval, the two-time winner of the competition added: "It was a tough time. More than the changes or the tactical talk, I told them to keep calm, keep confident and believe in ourselves."

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