Milan host Liverpool knowing they need a win to keep their Champions League hopes alive in one of the headline fixtures on Tuesday.
Real Madrid and Inter meet in a battle for top spot in Group D, with both already qualified as the Italian side travel to Spain with a woeful recent record.
Manchester City and Paris Saint-Germain are already through in Group A as well, with Lionel Messi aiming to follow in the footsteps of George Weah and Neymar at home to Club Brugge.
Stats Perform takes a look at the key Opta data behind the next set of matches.
Milan v Liverpool: Reds eye English record
Milan are searching for their first win against an English side in Europe since February 2012, while the Rossoneri have recorded victory in just one of their past nine home games in the Champions League group stage.
In contrast, Liverpool have triumphed in all five of their opening games this season as they look to become the first English side to win all six of their group-stage matches in a single campaign.
The Reds are also aiming to record victories in six consecutive games in the European Cup/Champions League for the first time in their history, with Alisson on the hunt for three consecutive clean sheets in the continental competition for his first time.
Paris Saint-Germain v Club Brugge: Mbappe and Messi await leaky defence
Club Brugge were defeated by five goals in their last clash against RB Leipzig, the third consecutive group game in which they conceded at least four times.
No team has ever gone four straight games letting in at least four, but the Belgians will have to negotiate with Messi, who could become just the third player – after Weah in 1994 and Neymar in 2017 – to score in his first three consecutive home games for PSG in the competition.
The visitors will also have to contend with Kylian Mbappe, the France international managing five goal involvements in three matches against Brugge – his joint-most against a single opponent in the competition, along with Red Star and Istanbul Basaksehir.
RB Leipzig v Manchester City: Guardiola's men out to defend German record
City are unbeaten in their previous 14 games against German opposition, including a six-game undefeated streak on the road, in a run that stretches back to November 2014 in the Champions League.
The reigning Premier League champions have won their past nine such fixtures, scoring 28 goals and conceding just nine in return, while Leipzig are winless in their most recent three meetings with English sides.
If Leipzig fail to defeat Pep Guardiola's side, it will be the first time they have not registered a single home win during the group stages in Europe.
Real Madrid v Inter: Los Blancos looking for goalscoring milestone
Inter have claimed just one win in their past 11 meetings with Spanish opposition in European competition and their last away win against such sides came all the way back in October 2004.
The Serie A outfit have not beaten Madrid in Europe since March 1967 as Carlo Ancelotti's side look to score their 1,000th goal in the European Cup/Champions League in just their 455th game.
Karim Benzema could be central to Madrid hitting that milestone if he is passed fit, the forward already with five group-stage goals to his name this term as he sits two behind Raul in the club charts in the competition (66).
Other fixtures:
Ajax v Sporting CP:
16 - Ajax have scored 16 goals in their five games in the Champions League this season, with only Bayern Munich (19) and Manchester City (17) finding the net more.
15 - The previous three meetings between Ajax and Sporting have seen a total of 15 goals scored, at an average of five goals per game. Indeed, neither side has managed to keep a clean sheet in any of their three clashes to date.
Borussia Dortmund v Besiktas:
60 - Jude Bellingham has had a direct hand in 60 per cent of Borussia Dortmund’s Champions League goals this season (one scored, two assisted), with the last Englishman to enjoy more than three goal involvements during the group stages of a season before the age of 19 being Jack Wilshere in 2010-11 for Arsenal (one scored, three assisted).
5 - Besiktas remain the only Champions League side in 2021-22 to lose all five of their matches and are looking to avoid being the first team since AEK Athens in 2018-19 to lose each of their six group games.
Porto v Atletico Madrid:
5 - Porto will be aiming to qualify for the knockout stages of the Champions League for a fifth time in their past five tournament appearances (2016-17, 2017-18, 2018-19 and 2020-21). The last time they failed to do so was in 2015-16 under Julen Lopetegui.
786 - Luis Suarez's only goal in 11 appearances for Atletico Madrid in the Champions League was a penalty against Milan in September, giving him a minutes-per-goal ratio of 786. At previous club Barcelona, the Uruguay striker scored 25 goals in 55 appearances, with a minutes-per-goal ratio of 192.
Shakhtar Donetsk v Sheriff:
1 - Shakhtar Donetsk have only won one of their past 11 home games in the Champions League (D5 L5), while they have failed to score in seven of the games in this run, including both in 2021-22 (D1 L1).
25 – Sheriff's 2-0 victory over Shakhtar in this season's tournament came despite the Moldovan side having just 25 per cent possession – since 2003-04, only Atletico (23) versus Barcelona in April 2016 have won a Champions League game by multiple goals with a lower possession percentage.
Gary Lineker congratulates Everton but ‘gutted’ as Leicester suffer relegation
Gary Lineker has congratulated Everton after his former club survived in the Premier League at the expense of his boyhood team Leicester.
The two clubs had been in jeopardy heading into the final round of fixtures on Sunday but ultimately Everton’s 1-0 victory over Bournemouth ensured they avoided the drop.
At one stage it looked as though it could be the Foxes who stayed up as they took an early lead against West Ham but their eventual 2-1 win was rendered academic by Everton’s result.
The Toffees ended the season in 17th place, two points ahead of Leicester, while Leeds were also relegated after a 4-1 loss to Tottenham.
Former England striker Lineker, who began his career at Leicester before spending a season at Everton in the mid-1980s, tweeted: “Absolutely gutted, but glad it’s Everton. Have a lot of love for that great football club. Congratulations.”
Leicester’s relegation comes seven years after they were crowned Premier League champions and just two years after they won the FA Cup.
Lineker added: “A word on Leicester. If eight years ago, you’d have given me the option of winning the Premier League and the FA Cup and then get relegated, I’d have snapped your hand off. Also I’d have told you not to be so utterly ridiculous.”
It has been a dismal season for Leicester and TV pundit Roy Keane was not sure how quickly they could recover.
The former Manchester United midfielder said on Sky Sports: “They didn’t seem to get any momentum into the season from a bad start. It’s no surprise to see them where they are.
“Clubs can bounce back but it isn’t easy. I think it is a rebuilding job at Leicester.”
Leeds’ three-year stint in the Premier League ended in a whimper as they were thrashed by Spurs at Elland Road.
The club had brought in Sam Allardyce in a last-ditch attempt to escape relegation with four games remaining but the former England boss was unable to engineer a recovery.
The team collected just one point from Allardyce’s games and finished in 19th position, five points behind Everton.
Keane was scathing of their performances.
He said: “They’ve looked weak over the last month or two, even with Sam coming in.
“They were fighting for their lives today and conceded four goals at home. That’s nowhere near good enough.
“Sam obviously came in too late. Defensively they look so weak. Some of the goals – it’s almost pub team defending.
“Not strong enough mentally, that desire – nowhere near good enough.”
Chelsea, meanwhile, aimed a parting shot at Leeds on social media.
Rivalry between those two clubs dates back to some hard-fought clashes in the 1960s and 70s.
In August, Leeds trolled Chelsea on Twitter during their 3-0 victory over the London club.
In that game, Chelsea tweeted the Blues were “starting to assert ourselves” just moments before Leeds opened the scoring and quickly followed with a second goal.
“Life comes at you fast!” Leeds tweeted in reply.
Now, nine months later, Chelsea have got their own back.
“It certainly does,” they tweeted.
Sir Elton John sends well-wishes as Jeff Stelling signs off from Soccer Saturday
Jeff Stelling revealed singer Sir Elton John was among his well-wishers this week as the presenter signed off from the “best job that anybody could possibly have wished for” at Soccer Saturday.
Stelling announced last month his intention to stand down as anchor of the Sky Sports programme after almost 30 years and earmarked the final day of the Premier League season on Sunday as his last show.
In the days leading up to his swansong, Stelling divulged he had messages of support from the likes of Gordon Strachan and Neil Warnock, plus a phone call from John, former chairman and director of Watford.
Stelling, an unapologetic Hartlepool fan who frequently celebrated their goals on Soccer Saturday, said: “Somebody asked me the other day if I’d ever been starstruck and yeah, I was starstruck when Elton John rang me at home to say ‘Thank you very much for all you’ve done’.
“He said ‘Every week I watch the show and every week you tell me Watford are losing and every week you tell me Hartlepool are losing so I feel like we’re kindred spirits’. There’s something in that, isn’t there?”
After touching tributes from colleagues past and present in a video montage, Stelling was given a standing ovation by the punditry panel of Paul Merson, Clinton Morrison, Kris Boyd and Michael Dawson.
Stelling, who had planned to quit last year before reversing that decision, briefly hid his emotions with a mask of himself and quipped: “This is tricky because I’ve changed my mind – just kidding.
“I haven’t changed my mind this time.”
Stelling was clearly moved by the highlights package Sky televised in the final minutes of the show after Everton retained their top-flight status and confirmed the relegations of Leeds and Leicester.
Merson, Alan Mullery, Frank McLintock, Clive Allen, Charlie Nicholas, Phil Thompson and Matt Le Tissier passed on their congratulations, as did Chris Kamara, who in a nod to the catchphrase that has become synonymous with the pair and the show, said: “You are unbelievable, Jeff!”
Stelling looked back fondly on his 30-plus years with Sky, in which he not only covered football but live snooker, darts, greyhound racing, pool and thanked everyone with whom he had worked.
In his farewell monologue, he added: “It’s been the best job that anybody could possibly have wished for. My wife takes great pleasure in saying ‘You are the luckiest man ever to take a breath’ and you know what? I don’t tell her this often but she’s right.
“The principle success of Soccer Saturday is you lot at home, who have given us unswerving support – both for the programme and for me personally.
“So that’s it. Soccer Saturday will be back next season. I’ll be watching – when Hartlepool are not playing. From me, goodbye.”
Espanyol suffer LaLiga relegation after dramatic Valencia draw
Espanyol were relegated from LaLiga after a dramatic draw with fellow strugglers Valencia on Sunday.
Luis Garcia's side will not be playing top-flight football next term after Samuel Lino's 93rd-minute goal snatched a 2-2 draw for Valencia, sending Espanyol down.
The White and Blues will join already relegated Elche in dropping down to the Segunda Division, while a host of other teams, including Real Valladolid, Celta Vigo, Almeria and Valencia, remain in danger.
Valladolid are in 18th place with one game remaining, one point behind Celta and Almeria, and two points adrift of Valencia, Getafe and Cadiz in a congested battle for survival.
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