Manchester United have concerns over David de Gea and Anthony Martial ahead of Sunday's derby with Premier League leaders Manchester City.
Neither De Gea nor Martial travelled to London for Wednesday's game with Crystal Palace at Selhurst Park.
Dean Henderson was named as starting goalkeeper, with Lee Grant among the substitutes, with De Gea absent due to personal reasons.
Ole Gunnar Solskjaer selected an attack of Marcus Rashford, Mason Greenwood and Edinson Cavani, with Martial having sustained a knock during training.
It is unclear whether either player will be available to face City at the Etihad Stadium.
"David, that's personal reasons," United manager Solskjaer told MUTV about the absences.
"Anthony got a knock in training on Monday, on his knee, so [he is] not ready for this. Hopefully, [he will be] ready for the weekend but we're not sure yet."
Henderson has only started twice in the league this season and there are reports he could ask to leave Old Trafford if he is not assured of more playing time next season, the former Sheffield United loanee having mostly been limited to European and domestic cup appearances.
"Let's hope he performs as well as he has done all season," said Solskjaer. "He's got his chance now. He's been waiting patiently, he's been working really hard and of course he's ready to grab his opportunity."
Erik ten Hag says Manchester United ‘have to learn’ from Galatasaray draw
Erik ten Hag says Manchester United are conceding too many goals but refused to blame Andre Onana despite the goalkeeper’s errors at Galatasaray severely damaging their chances of Champions League progression.
Having lost three of four Group A games, Wednesday’s key clash in Istanbul began in dream fashion as Alejandro Garnacho’s early effort was followed up by a Bruno Fernandes rocket.
Hakim Ziyech pulled one back from a free-kick that Onana will be disappointed to have been beaten by and he was guilty of an even worse error after Scott McTominay scored United’s third.
The summer signing somehow failed to deal with another Ziyech free-kick and substitute Kerem Akturkoglu soon lasered past him as a mad match ended 3-3.
The result leaves United bottom of their pool heading into the final round of fixtures, with the concession of 14 goals in just five Group A games the key issue.
“We scored also quickly after each other,” United manager Ten Hag said.
“It’s about the point when you are leading, when you are 2-0 up and you have to manage the game. Not so easy.
“We give free-kicks away and we have to defend them better twice. I have to say also that is Hakim. He is brilliant, I know that. He is extraordinary.
“To give free-kicks, it’s difficult to defend as well. In such areas, we have to be in more control.
“It is always about incidents, always about details and some incidents we can manage better.
“As a team, we have to learn from it because we are conceding too many goals and it is unnecessary and avoidable.
“I am sure our team is experienced enough and capable enough to manage this and we will do better.
“What is enjoyable is the progress we have and the way we play football. We dictated the game, we scored so many goals – it was about plan, creativity, being proactive and brave. That makes me happy.”
United should have scored more but Onana will be under the spotlight after this draw, having also been guilty of errors in the losses away to Bayern Munich and at home to Galatasaray.
While his key stoppage-time penalty save secured a win against Copenhagen, he endured another difficult Champions League night on Wednesday.
“I think as a team we played very well,” Ten Hag said when asked about Onana. “We win and lose together. You see the progress in this team.
“I take many positives from this game. Some mistakes. We played like I want my team to play.
“It was enjoyable to watch that proactive, dynamic, brave and we scored great goals.
“Even after we had some setbacks, we kept going until the end and we should have won with big chances from Scott McTominay and (Facundo) Pellistri.
“Of course, I am disappointed because we should have managed the game better, we will learn from that. Because this team is in development.”
Asked how Onana is, he said: “He is OK. As I said, it is not about individuals.
“Of course, individual errors in football can make a difference and you take responsibility for it but it is always about the team.
“This team is good, all the players in the squad are good and deserve the best to play for Manchester United because they are brilliant players.
“And that counts for the whole squad.”
United are now sweating on their place in Europe, let alone the Champions League, heading into their group finale against already-qualified Bayern at Old Trafford.
“It would be more frustrating if we play poor,” Ten Hag said.
“But the performance is very good, it is enjoyable to watch how we dictate the game, how we create chances, that is actually fantastic.
“But now there is more, if you can sort better the management of the game out then you start playing football.
“The football is good, the performances are good but now we have to learn better how to manage this game.”
Manchester United throw away two-goal lead in Galatasaray Champions League draw
Manchester United’s Champions League hopes are hanging by a thread after Erik ten Hag’s men imploded in a chaotic, thrill-a-minute 3-3 draw on an ear-splitting night at Galatasaray.
Having lost three of their four Group A fixtures, the Red Devils knew defeat in Istanbul would extinguish their hopes of reaching the knockout phase with a game to spare.
United avoided a loss but blew a two-goal lead on in an incredible night in Istanbul, meaning their knockout hopes will be over if Copenhagen beat Bayern Munich in Wednesday’s late fixtures.
This was a wild, helter-skelter encounter befitting of a Champions League campaign punctuated by goals, madness and mistakes.
A rocking Rams Park witnessed a dream United start to a breathless match, with Alejandro Garnacho completing a fine team move before Bruno Fernandes rocketed the visitors further ahead in the 18th minute.
Hakim Ziyech’s free-kick all too easily beat Andre Onana to give Galatasaray hope, which Scott McTominay appeared to extinguish when scoring in the 55th minute.
But United, not for the first time in Group A, unravelled as Onana’s howler allowed Ziyech to score another free-kick before substitute Kerem Akturkoglu levelled with a scorcher.
Fernandes hit the post from distance and Facundo Pellistri somehow failed to score as the visitors laid siege to Galatasaray’s goal, with the draw leaving them bottom of Group A and facing an early Champions League exit.
Man Utd set to face Galatasaray in Champions League despite bad weather
Manchester United’s match at Galatasaray is set to go ahead after bad weather throughout the day in Istanbul had put the Champions League clash in doubt.
Relentless rain has been falling in the Turkish city throughout the day and there are concerns over the state of the pitch at Rams Park.
A statement from UEFA said: “We are closely monitoring the weather forecast and at this time the match will go ahead as scheduled.”
United and Galatasaray arrived as planned, beginning their warm-ups as scheduled.
Erik ten Hag’s men go into the match bottom of Group A having lost three of their four games so far in this season’s competition, and without a win away to Galatasaray in their last three visits.
Galatasaray twice came from behind to win 3-2 when the sides met at Old Trafford in October, with Mauro Icardi scoring an 81st-minute winner after United midfielder Casemiro had been sent off.
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