Liverpool were stunned by Brighton and Hove Albion at Anfield as they lost for the second home Premier League game in a row, while Manchester City stretched their winning streak at Burnley.
Having seen their 68-game unbeaten home league run ended by Burnley two weeks ago, the champions again came unstuck against an improving Brighton side.
Liverpool's next opponents are leaders City, who had less trouble seeing off Burnley as they made it 13 victories in a row in all competitions - the longest such run by a Premier League side since Arsenal between March and August 2002 (also 13).
There were also victories for Leicester City, Everton and West Ham on Wednesday, overcoming Fulham, Leeds United and Aston Villa respectively.
Here is the pick of the Opta facts on a day in which history was made as all five away sides triumphed.
Burnley 0-2 Manchester City: Jesus and Sterling keep winning run going
Twenty-four hours on from Manchester United's record-equalling 9-0 win against Southampton, City regained a three-point lead at the summit with a game in hand thanks to a routine victory at Turf Moor.
Gabriel Jesus scored for the third game in a row that he has started to give City an early lead and Raheem Sterling marked his recall to the starting line-up with his 99th goal under Pep Guardiola in all competitions.
Burnley offered little in response as they failed to register a single shot on target for the second game running, making them the first Premier League side to do so since Everton in January 2018.
It meant for a quiet day for City's defenders as they kept a sixth straight shutout in the competition - their joint-longest run without conceding - in what was a 12th successive victory in games played on a Wednesday, which is a Premier League record.
Burnley will be glad to see the back of City for another season having now lost to them by an aggregate 10-0 scoreline across their three meetings in all competitions this season, the other defeat coming in the EFL Cup.
Fulham 0-2 Leicester City: Maddison inspires Foxes to another away win
Kelechi Iheanacho's first Premier League goal in 15 appearances and a second strike of the season for James Justin earned Leicester all three points at Fulham.
James Maddison set up Iheanacho and Justin to take his goal involvement to 12 - six goals and as many assists - in his last 12 outings in all competitions, with this the first occasion he has laid on more than one goal in a Premier League match.
Leicester have now collected 26 points on their travels this season, which is already their second-highest tally in a campaign after their 2015-16 title success (39 points).
As for Fulham, they have now gone 11 games without a win in the Premier League and have lost their opening four home games of a calendar year in all competitions for the first time in their English Football League history.
Leeds United 1-2 Everton: Toffees earn rare Elland Road triumph
Everton made it four consecutive away league victories for the first time since December 1985 through first-half goals from Gylfi Sigurdsson and Dominic Calvert-Lewin.
This may just be the sweetest victory of the lot during that run, given it is only their second at Elland Road in the top flight in 38 attempts - the most recent before today coming in 2002.
It is the fifth home league match Leeds have lost in 10 games this term - the last time a Marcelo Bielsa side lost more at home in the league in a single season was Athletic Bilbao in the 2012-13 LaLiga campaign.
Sigurdsson put Everton on their way with another goal assisted by Lucas Digne - the sixth he has set up in the Premier League this season, which is the most by any defender.
Only Liverpool pair Trent Alexander-Arnold and Andy Robertson (both 28) have registered more than Digne's 17 assists since the start of the 2018-19 season.
Calvert-Lewin doubled his side's tally with his ninth headed goal in the Premier League since the start of last season - only Bayern Munich striker Robert Lewandowski (12) has scored more in Europe's top five leagues over that period.
Aston Villa 1-3 West Ham: Lingard at the double on Hammers bowJesse Lingard marked his first appearance for West Ham since joining on loan from Manchester United with a couple of goals against Aston Villa.
The England international is only the second player for the club to achieve that two-goal debut feat after Trevor Sinclair against Everton in January 1998.
Lingard's double came after Tomas Soucek had given West Ham the lead with his eighth league goal of the season - the most of any midfielder when excluding penalties.
Ollie Watkins gave Villa temporary hope at 2-0 but the home side could not avoid a fourth defeat in their last six league matches, compared to only four losses in their opening 14.
David Moyes has plenty of reasons to be cheerful, having overseen three successive away wins in the competition for the first time since April 2014 when at Man United, with this latest victory taking West Ham to 38 points - their highest top-flight tally after 22 games since 1985-86.
Liverpool 0-1 Brighton and Hove Albion: Alzate stuns stuns toothless champions
Liverpool's home struggles continued with defeat to Brighton, who picked up a victory in this fixture for the first time in 13 meetings in all competitions - and a first at Anfield since 1982.
The Merseyside club having now lost consecutive games at Anfield in the top flight for the first time since September 2012, having gone 68 without a home loss in the Premier League.
It is four Premier League games at Anfield without a win, meanwhile, the last three of those without scoring - the first time that has happened since October 1984 - in a goalless run spanning 348 minutes and counting.
Steven Alzate was the match-winning hero for Brighton with his first Premier League goal in his 28th appearance, coming from the first shot on target of the contest.
Toothless Liverpool offered little in reply, testing opposition keeper Robert Sanchez just once as Brighton made it four top-flight clean sheets on the bounce for the first time in their history.
Virtual reality could help improve heading skills amid new restrictions – study
Virtual reality could help footballers improve their heading without the repetitive head impacts from a ball, a new study indicates.
Players involved in a study at Manchester Metropolitan University’s Institute of Sport and its Department of Sport and Exercise Sciences demonstrated greater performance in ‘real world’ heading after training with a VR headset compared to a control group who did no training.
The VR group also reported greater self-confidence and efficacy in their heading compared to the control group, the study found.
The study, titled: ‘A preliminary investigation into the efficacy of training soccer heading in immersive virtual reality’, has been published in the journal Virtual Reality on Tuesday.
It provides some insights into how players may be able to improve heading technique amid restrictions on training.
Football Association guidelines advise against any heading training in under-12s, while a trial is ongoing in the current season and next season to eliminate deliberate heading completely from matches up to and including that age group.
At ages 12 and 13, heading should be limited to a single session of no more than five headers, and no more than 10 headers per session for children aged 14 to 17, according to FA guidance.
Even in adult football at all levels, players are advised to perform only 10 ‘higher force headers’ per training week, such as headers from crosses, corners, free-kicks and returning of goal kicks.
The exposure to heading has been limited because of concerns over the sub-concussive impact of repetitive heading on a player’s longer-term wellbeing.
The 2019 FIELD Study found professional footballers were three and a half times more likely to die of neurodegenerative disease than age-matched members of the general population.
“With increasing restrictions of heading exposure to professional and youth soccer, it is evident that alternative methods for training heading confidence and technique will be required while it remains an integral part of the game,” the VR paper concluded.
“The work presented here provides some initial evidence suggesting that immersive VR may have a place in any new approach to training this important skill.”
A group of 36 adult recreational-level players, made up of 30 men and six women, participated in the study in total.
The 36 were split into two groups of 18, with 16 men and two women in the control group who did not use the VR headsets between ‘real world’ heading sessions, and 14 men and four women in the VR group.
The VR group used the Oculus Quest 2 head-mounted display, with the Rezzil Player 22 application used to provide the VR football heading training.
Dr Ben Marshall, Lecturer in Sport and Exercise Psychology at the Manchester Metropolitan University Institute of Sport, said: “Our findings show that virtual reality (VR) based training can be used to improve real-world heading performance and that this method is more effective than not training the skill at all.
“This is important as current training guidelines recommend limiting the number of physical headers performed in training for all age groups due to the associated long-term risks to player health.
“Our findings suggest the inclusion of VR-based training could play an important role in developing football heading skills whilst reducing the number of real-world headers and sub-concussive head impacts that players need to be exposed to – which is really positive.”
Caglar Soyuncu and Daniel Amartey among seven players leaving Leicester
Leicester have confirmed seven players will depart the club at the end of their contracts in June, including Caglar Soyuncu and Daniel Amartey.
The announcement comes following the Foxes’ relegation to the Championship on the final day of the Premier League season last month.
Turkish defender Soyuncu joined in 2018 from Freiburg and has featured over 100 times for Leicester, while fellow centurion Amartey made his first appearances for the club during their Premier League title-winning season in 2016.
Youri Tielemans is also among those leaving, having announced his exit on Instagram last week after spending four years with the club since joining from Monaco in 2019.
Nampalys Mendy, Ryan Bertrand, Ayoze Perez and Tete are the remaining players who are to leave the King Power following the expiration of their contracts.
Captain Jonny Evans remains in discussions with the Foxes as his contract is set to expire this month, while an option has been exercised to extend Hamza Choudhury’s contract to June 2024.
Inter boss Simone Inzaghi calls opponents Man City ‘strongest team in the world’
Simone Inzaghi will send Inter Milan into Champions League battle with “the strongest team in the world” on Saturday evening.
Inter will go head-to-head with English double winners Manchester City in Istanbul, with Pep Guardiola’s men hot favourites to complete the same treble won by arch-rivals Manchester United in 1999.
However, Inzaghi has told his players not to fear the challenge ahead of them as they attempt to repeat the feat of their predecessors in 2010.
The 47-year-old head coach told a press conference: “I know we’ll meet the strongest team in the world at the moment. We face the best.
“We’re talking about a football match and with all due respect, I’m not afraid of anything.
“Guardiola is the best coach in the world and he has marked an era. We have respect, but we are proud to play in this final that we wanted with all our strength.
“It will be the last of 57 matches in which even the much-talked-about defeats have allowed us to get to where we will be on Saturday.”
Asked if the game would be the biggest of his illustrious career, Inzaghi added: “Yes it is, for me and for my players.
“[Andre] Onana and [Edin] Dzeko have played in the semi-finals, but nobody has ever made it to the final. It pays us back for all the efforts made throughout the year.”
Much of the focus in the build-up to the game has centred on the threat posed to Inter’s hopes by 52-goal City striker Erling Haaland, even though the Norway international has scored only once in his last seven appearances.
Inzaghi, who revealed he had unexpectedly bumped into Guardiola at a New York hotel during his honeymoon in 2019, said: “Haaland said City bought him to win the Champions League, but City isn’t just Haaland; they have numerous players who can put us in trouble.
“[Real Madrid’s Antonio] Rudiger managed to stop him very well in the semi-final and we’ll try to take our cue from that.”
That was a theme taken up by defender Alessandro Bastoni, who warned his team-mates not to ignore the danger posed by Bernardo Silva and Kevin De Bruyne in particular.
Bastoni said: “City bought Haaland to win the Champions League, but they also have Bernardo [Silva] and [Kevin] De Bruyne who can put us in trouble.
“I watched a video of how Rudiger stopped Haaland and we will try to do the same. But it’s not Inter against Haaland, it’s Inter against City.”
Inzaghi remained coy over his team selection, insisting he is yet to make a decision over whether to start Dzeko or Romelu Lukaku in attack, adding: “A coach can have ideas, but maybe he changes his mind at the last second.”
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