Liverpool were stunned by Brighton and Hove Albion at Anfield as they lost for the second home Premier League game in a row, while Manchester City stretched their winning streak at Burnley.
Having seen their 68-game unbeaten home league run ended by Burnley two weeks ago, the champions again came unstuck against an improving Brighton side.
Liverpool's next opponents are leaders City, who had less trouble seeing off Burnley as they made it 13 victories in a row in all competitions - the longest such run by a Premier League side since Arsenal between March and August 2002 (also 13).
There were also victories for Leicester City, Everton and West Ham on Wednesday, overcoming Fulham, Leeds United and Aston Villa respectively.
Here is the pick of the Opta facts on a day in which history was made as all five away sides triumphed.
Burnley 0-2 Manchester City: Jesus and Sterling keep winning run going
Twenty-four hours on from Manchester United's record-equalling 9-0 win against Southampton, City regained a three-point lead at the summit with a game in hand thanks to a routine victory at Turf Moor.
Gabriel Jesus scored for the third game in a row that he has started to give City an early lead and Raheem Sterling marked his recall to the starting line-up with his 99th goal under Pep Guardiola in all competitions.
Burnley offered little in response as they failed to register a single shot on target for the second game running, making them the first Premier League side to do so since Everton in January 2018.
It meant for a quiet day for City's defenders as they kept a sixth straight shutout in the competition - their joint-longest run without conceding - in what was a 12th successive victory in games played on a Wednesday, which is a Premier League record.
Burnley will be glad to see the back of City for another season having now lost to them by an aggregate 10-0 scoreline across their three meetings in all competitions this season, the other defeat coming in the EFL Cup.
Fulham 0-2 Leicester City: Maddison inspires Foxes to another away win
Kelechi Iheanacho's first Premier League goal in 15 appearances and a second strike of the season for James Justin earned Leicester all three points at Fulham.
James Maddison set up Iheanacho and Justin to take his goal involvement to 12 - six goals and as many assists - in his last 12 outings in all competitions, with this the first occasion he has laid on more than one goal in a Premier League match.
Leicester have now collected 26 points on their travels this season, which is already their second-highest tally in a campaign after their 2015-16 title success (39 points).
As for Fulham, they have now gone 11 games without a win in the Premier League and have lost their opening four home games of a calendar year in all competitions for the first time in their English Football League history.
Leeds United 1-2 Everton: Toffees earn rare Elland Road triumph
Everton made it four consecutive away league victories for the first time since December 1985 through first-half goals from Gylfi Sigurdsson and Dominic Calvert-Lewin.
This may just be the sweetest victory of the lot during that run, given it is only their second at Elland Road in the top flight in 38 attempts - the most recent before today coming in 2002.
It is the fifth home league match Leeds have lost in 10 games this term - the last time a Marcelo Bielsa side lost more at home in the league in a single season was Athletic Bilbao in the 2012-13 LaLiga campaign.
Sigurdsson put Everton on their way with another goal assisted by Lucas Digne - the sixth he has set up in the Premier League this season, which is the most by any defender.
Only Liverpool pair Trent Alexander-Arnold and Andy Robertson (both 28) have registered more than Digne's 17 assists since the start of the 2018-19 season.
Calvert-Lewin doubled his side's tally with his ninth headed goal in the Premier League since the start of last season - only Bayern Munich striker Robert Lewandowski (12) has scored more in Europe's top five leagues over that period.
Aston Villa 1-3 West Ham: Lingard at the double on Hammers bowJesse Lingard marked his first appearance for West Ham since joining on loan from Manchester United with a couple of goals against Aston Villa.
The England international is only the second player for the club to achieve that two-goal debut feat after Trevor Sinclair against Everton in January 1998.
Lingard's double came after Tomas Soucek had given West Ham the lead with his eighth league goal of the season - the most of any midfielder when excluding penalties.
Ollie Watkins gave Villa temporary hope at 2-0 but the home side could not avoid a fourth defeat in their last six league matches, compared to only four losses in their opening 14.
David Moyes has plenty of reasons to be cheerful, having overseen three successive away wins in the competition for the first time since April 2014 when at Man United, with this latest victory taking West Ham to 38 points - their highest top-flight tally after 22 games since 1985-86.
Liverpool 0-1 Brighton and Hove Albion: Alzate stuns stuns toothless champions
Liverpool's home struggles continued with defeat to Brighton, who picked up a victory in this fixture for the first time in 13 meetings in all competitions - and a first at Anfield since 1982.
The Merseyside club having now lost consecutive games at Anfield in the top flight for the first time since September 2012, having gone 68 without a home loss in the Premier League.
It is four Premier League games at Anfield without a win, meanwhile, the last three of those without scoring - the first time that has happened since October 1984 - in a goalless run spanning 348 minutes and counting.
Steven Alzate was the match-winning hero for Brighton with his first Premier League goal in his 28th appearance, coming from the first shot on target of the contest.
Toothless Liverpool offered little in reply, testing opposition keeper Robert Sanchez just once as Brighton made it four top-flight clean sheets on the bounce for the first time in their history.
Leeds chairman Andrea Radrizzani completes Sampdoria takeover
A consortium that includes Leeds chairman Andrea Radrizzani has completed its takeover of Italian club Sampdoria.
Leeds’ majority shareholder Radrizzani’s company Aser Group and finance company Gestio Capital announced they had concluded a deal to save financially-stricken Sampdoria late on Tuesday night.
In a statement released on Sky Sports Italian reporter Gianluca Di Marzio’s social media sites, Radrizzani said: “We are nothing short of thrilled to be able to announce that we have completed the acquisition of this extraordinary club.
“The history and coat of arms of Sampdoria are safe and I think my happiness is (for) of all the people who were suffering for these colours.
“My thanks at this time go above all to all those people who worked relentlessly to ensure that this agreement found a just conclusion.
“And in particular I have to extend a huge thank you to Matteo (Manfredi, Gestio Capital principal) and to the lawyer De Gennaro.
“Without them none of this would have been possible. From today we move on…. and I personally can’t wait to get to work.”
Radrizzani, who bought Leeds for £45million in 2017, is expected to sell his 56 per cent stake in the Premier League club to American co-owners 49ers Enterprises.
The financial arm of NFL franchise the San Francisco 49ers increased its stake in Leeds to 44 per cent at the end of 2021 with a deal in place to buy Radrizzani’s stake and take full control before January 2024.
49ers Enterprises has been reported to be keen to complete a takeover this summer, but the deal was contingent on Leeds remaining in the Premier League and it remains to be seen how relegation will affect a possible change of ownership at Elland Road.
Leeds’ three-year stay in the top flight was ended on Sunday when they lost 4-1 to Tottenham at Elland Road in their last game of the season.
Pep Guardiola takes top honours at LMA Awards
Manchester City boss Pep Guardiola has been named the League Managers Association’s manager of the year.
Guardiola, who has guided City to a third straight Premier League title and is hunting a domestic treble, has won the Sir Alex Ferguson trophy for a third time and was also named Premier League manager of the year.
City face Manchester United in the FA Cup final on Saturday and Inter Milan in the Champions League final.
Guardiola, who has previously won the award in 2017-18 and 2020-21, said: “I’m delighted to receive the Premier League Manager of the Year. It’s an incredible honour to get his trophy.
“We are in the best league in the world and I promise you we will be there next season.”
Arsenal head coach Mikel Arteta, Brighton’s Roberto De Zerbi, Newcastle’s Eddie Howe, Aston Villa boss Unai Emery and Fulham’s Marco Silva had all been nominated.
Vincent Kompany, who guided Burnley straight back to promotion to the top flight, won the Championship award, beating fellow nominees Michael Carrick (Middlesbrough), Paul Heckingbottom (Sheffield United), Rob Edwards (Luton) and Mark Robins (Coventry).
Kompany said: “The players have done it and the staff have been relentless.
“I can still relate to the players, I feel connected to what they are going through. I make mistakes and don’t see myself as the finished article. You make mistakes and learn. I’m pretty pleased where I am today.”
Plymouth boss Steven Schumacher took the League One award after guiding the Pilgrims to the title and Richie Wellens was voted League Two manager of the year after leading Leyton Orient to the top of the fourth tier.
Manchester United’s Anthony Martial ruled out of FA Cup final through injury
Manchester United forward Anthony Martial has been ruled out of Saturday’s FA Cup final against Manchester City due to a hamstring injury.
Martial picked up the problem in United’s final Premier League game of the season after stepping off the bench on Sunday against Fulham and scans have revealed the full extent of the damage.
United said in a statement: “Anthony Martial is out of Saturday’s Emirates FA Cup final against Manchester City due to injury.
“The France international strained his hamstring towards the end of Sunday’s 2-1 win against Fulham at Old Trafford.
“Assessments have since revealed a muscle tear that rules the 27-year-old out of the Wembley showdown.”
Martial missed United’s first two Premier League games this season due to a hamstring problem, while other small injuries since have restricted him to 29 appearances in all competitions in which he has scored nine goals.
Only 11 of his 21 league appearances this season have been in the starting line-up, but he had been hoping to be in contention to start at Wembley against City, who are looking to complete a domestic treble.
The former Lyon winger, who spent the second half of last season on loan at Sevilla, joined United from Monaco for £36million in 2015 and has made almost 200 league appearances for the club in total.
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