Simona Halep revealed her Rome withdrawal this week was caused by a torn calf muscle, a blow that casts doubt on her prospects of playing the French Open.

Former world number one Halep had to be helped off court by coach Darren Cahill after she was injured while leading Angelique Kerber 6-1 3-3 in the second round of the Internazionali d'Italia on Wednesday.

The two-time grand slam champion on Friday announced the extent of her injury. Her misfortune comes with just over two weeks remaining until the clay-court grand slam at Roland Garros gets under way on May 30.

Wimbledon is the next major on the calendar after the Paris slam, with the All England Club tournament scheduled to start on June 28 in London.

"After an MRI here in Rome I can confirm that I have small tear high up in the left calf," Romanian Halep posted on her social media accounts.

"I will fly home today and begin recovery in the pool and gym on Monday.

"I'm staying positive and will do everything i can to speed up my return."

Halep, now 29 years old, won her first major title in Paris three years ago and went on to be crowned Wimbledon champion in 2019.

Ash Barty will meet Coco Gauff in the quarter-finals of the Internazionali BNL d'Italia after an impressive defeat of Veronika Kudermetova.

The world number one claimed her 27th Tour-level win of this year, seeing off Kudermetova 6-3 6-3 in 81 minutes to reach the last eight in Rome for the first time.

Barty admitted it took some time to get used to the "wow factor" of centre court in the Italian capital, but she rarely looked under threat as she moved to 13-2 on clay in 2021.

The Australian would have faced Aryna Sabalenka for the third tournament in a row had it not been for a sterling performance from Gauff, who won 7-5 6-3 to secure a fourth quarter-final this year.

"Coco has shown that she loves to bring her best tennis against the players that challenge her the most," said Barty, who has never played against the American teenager. "She's played an exceptional tournament thus far. She's got the ability to take the game on. She's aggressive, she can run, she can trust her legs.

"I think it's going to be important for me to try to get the match back on my terms as often as possible. I know when they're in her patterns, the way she likes to play, she's extremely dangerous and very good at what she does. I think it's going to be a new challenge, a clean slate for both of us."

Matters were more difficult for reigning French Open champion Iga Swiatek, who saved two match points before beating Barbora Krejcikova 3-6 7-6 (7-5) 7-5 in a contest lasting nearly three hours.

Powerful serving from Krejcikova and some errant shots from Swiatek gifted the Czech the chance to serve out a straight-sets win, but Swiatek held firm before taking the tie-break.

Swiatek persisted with a drop shot that seemed to cause difficulties for her and her opponent before Krejcikova's aim went awry at the end of the decider.

"I had fun when I played drop shots because today I felt them really good," said Swiatek, who will now face fifth seed Elina Svitolina after her 6-4 6-2 beating of Garbine Muguruza.

"I asked myself a question, what would annoy me in that situation? So, I tried to do that. So, yeah, sometimes it didn't look pretty, but I'm happy that I could do that. One year ago I wouldn't even come up with a solution like that. That's a progress."

Jessica Pegula followed up her shock win over Naomi Osaka by defeating Ekaterina Alexandrova in straight sets. She will now face Petra Martic, who came from a set down to defeat world number 44 Nadia Podoroska – conqueror of Serena Williams on Wednesday.

Ninth seed Karolina Pliskova, who beat Vera Zvonareva 7-5 6-3, will face Jelena Ostapenko following her three-set defeat of Angelique Kerber.

Serena Williams will play in the Emilia-Romagna Open next week following her early exit in Rome, Patrick Mouratoglou has confirmed.

The legendary American was beaten 7-6 (8-6) 7-5 by Nadia Podoroska in the 1,000th match of her incredible career at the Internazionali BNL d'Italia on Wednesday.

Williams, who was given a bye into the second round at Foro Italico, was playing her first match since losing to Naomi Osaka in the semi-finals of the Australia Open three months ago.

With the French Open getting under way on May 30, Williams has taken a wildcard to get more time on clay under her belt in Parma.

Mouratoglou, the former world number one's coach, tweeted: "Change of plans: Serena hasn't been competing for a while, and we want to get as many matches under our belt as possible before Roland-Garros - so we're adding the Emilia-Romagna Open to our schedule.

"We'll be back in action next week."

Williams will head to Paris for the second major of the year in her latest attempt at matching Margaret Court's record tally of 24 grand slam singles titles.

Novak Djokovic cruised into the quarter-finals of the Internazionali d'Italia with a straight-sets demolition of Alejandro Davidovich Fokina on Thursday.

The world number one took just an hour and 10 minutes to wrap up an emphatic 6-2 6-1 victory at the Foro Italico.

Davidovich Fokina broke the top seed's serve in the first game of the match, but that proved to be a false dawn for the Spanish qualifier.

Djokovic put the 21-year-old under huge pressure with another returning masterclass, breaking back immediately and on two more occasions to seal the first set.

The 18-time grand slam champion was relentless in the second set, forcing Davidovich Fokina's unforced error count up to 30 as he breezed into the last eight.

Djokovic, who has reached at least the quarter-final stage in each of his 15 appearances at the prestigious tournament in Rome, was waiting to learn whether he would face Stefanos Tsitsipas or Matteo Berrettini for a place in the semi-finals.

The Serbian said: "I thought I played well. He started well and broke my serve in the first game. I made some errors, but I managed to break back right away and establish the control and consistency on the court.

"I think from the back of the court I was just a bit more solid than him.

"He made some unforced errors and double faults in key moments, which obviously helped me get that necessary break forward.

"I thought I played better, at least 20 or 30 per cent better, than I did against [Taylor] Fritz a few days ago. I am on a good trajectory and hopefully tomorrow will be even better."

Simona Halep suffered a worrying leg injury just over two weeks out from the French Open at the Internazionali BNL d'Italia, where Serena Williams and Naomi Osaka crashed out.

Halep, the 2018 French Open champion, had dominated the first set against Angelique Kerber, winning 6-1, but came off the court with an apparent calf problem with the scores level at 3-3 in the second.

She received treatment but an emotional Halep was forced to withdraw from the clash, the defending champion handing victory to Kerber.

The Romanian was then helped from the grandstand court, leaving the area with strapping on her leg and a heavy limp, raising doubts about her ability to compete at Roland Garros, where she would likely be one of the favourites.

Earlier Williams made her first appearance on the tour since February, losing the 1,000th match of her glittering career to Nadia Podoroska, who reached the semi-finals in Paris last year.

Podoroska prevailed 7-6 (8-6) 7-5, with 23-time grand slam champion Williams not too downhearted by a defeat to an accomplished clay-court player.

"It's tough to have a first match on clay. It was definitely kind of good to go the distance and to try to be out there, but clearly I can do legions better," Williams said. 

"She has a good game, for sure, obviously. She's very consistent. Overall, it was good for me to play such a clay-court player on clay today, but it's a little frustrating. But it's all right. It is what it is.

"I have been training for months, but it feels definitely different on clay to make that last adjustment. Just filling out the game, finding the rhythm. Even sliding and confidence with that, with movement. That's always like a little struggle in the first two matches, and then I'm raring to go."

Osaka has yet to find her footing on clay and the reigning Australian Open champion came up short in the second round as she suffered a surprise loss to Jessica Pegula.

Pegula said after her 7-6 (7-2) 6-2 win: "I know she doesn't love clay, so I just tried to be the clay court player out there today, and it worked just good enough."

World number one Ashleigh Barty had no such difficulties in her 6-4 6-1 over Yaroslava Shvedova, but fourth seed Sofia Kenin was a shock loser to Barbora Krejcikova.

Petra Kvitova was beaten in three sets by Vera Zvonareva but Madrid champion Aryna Sabalenka, last year's French Open champion Iga Swiatek, Elina Svitolina, Karolina Pliskova and Garbine Muguruza all progressed while teenager Coco Gauff knocked out 17th seed Maria Sakkari.

Serena Williams made an unsuccessful return to the WTA Tour as she joined Naomi Osaka in crashing out of the Internazionali BNL d'Italia in the second round on Wednesday.

Williams was playing the 1,000th match of her glittering career against Nadia Podoroska, her first since losing in the Australian Open semi-finals to Osaka in February.

The American has experienced significant success in Rome, winning the title four times, but was always likely to be tested by a player who reached the French Open semi-finals last year.

And that proved the case as she slumped to a 7-6 (8-6) 7-5 defeat despite threatening a second set fightback.

Having won the first set on a tie-break, Podoroska continued to dominate the longer exchanges and went 5-2 up in the second.

From there, Williams won 12 straight points to level matters at 5-5, but Podoroska then claimed a nervy service hold to force the 23-time grand slam champion to serve to stay in the match.

She never came close to doing so as Williams was broken to love, a miscued forehand long giving Podoroska one of the biggest wins of her career.

Earlier in the day, Osaka was defeated in straight sets by Jessica Pegula.

Osaka has made no secret of her discomfort on clay, having never gone beyond the third round at Roland Garros.

All of her 10 WTA singles titles have come on the hard court and she was undone on the red dirt once more as Pegula prevailed 7-6 (7-2) 6-2.

Novak Djokovic returned following a rain delay to beat Taylor Fritz in the second round of the Internazionali BNL d'Italia after Felix Auger-Aliassime dumped Diego Schwartzman out.

Djokovic, playing his first match since a shock loss to Aslan Karatsev in the semi-finals of the Serbia Open on home soil, dispatched American Fritz 6-3 7-6 (7-5) on Tuesday.

The world number one, who missed the Madrid Open, won the first three games of the match and saved both break points he faced in the opening set.

Fritz had broken for a second time in the second set to level at 5-5 when the rain came at the Foro Italico, but the top seed was able to come back out on court to finish off the job and will face Cameron Norrie or Alejandro Davidovich Fokina in the third round.

Auger-Aliassime secured the third victory over a top-10 opponent in his fledgling career, beating eighth seed Schwartzman 6-1 6-3 to move into round three.

The 20-year-old Canadian only needed 64 minutes to send the Argentine packing, converting five of the six break-point opportunities he earned.

Matteo Berrettini saw off Nikoloz Basilashvili 4-6 6-2 6-4 in the first round less than 48 hours after the Italian was beaten by Alexander Zverev in the Madrid Open final.

Gael Monfils was unable to win his first match since the Australian Open, as Lorenzo Sonego got the better of the fit-again Frenchman, who had been sidelined with a calf injury, 6-4 5-7 6-4.

Reilly Opelka moved into the last 16 with a 6-4 6-4 defeat of Lorenzo Musetti, while Pablo Carreno Busta's withdrawal due to lower back pain handed Kei Nishikori a walkover.

Daniil Medvedev and David Goffin were unable to start their second-round matches due to the weather in Rome.

Garbine Muguruza eased into the second round of the Internazionali BNL d'Italia on Tuesday thanks to a comfortable victory over lucky loser Patricia Maria Tig, though Belinda Bencic was the biggest casualty on a rain-interrupted day.

Spaniard Muguruza was due to face Anastasia Pavlyuchenkova until the Russian withdrew due to an abdominal issue, giving Tig a reprieve and the chance of an upset.

But Muguruza won all but three games in a comprehensive 6-1 6-2 victory that required little more than an hour on court as the former world number one went to 22-6 for the season.

Conditions were not great as drizzle persisted for much of the match, but Muguruza was grateful to progress after a generally testing day.

"It was a weird day," the 12th seed said afterwards. "I woke up [and the weather was] sunny, had an opponent. Then it turned out I had another opponent and it was raining the whole match. We had a little bit of everything!

"But, Rome, it's such a familiar tournament. I played here so many times, I've had nice matches. I love this clay, the red clay. It's familiar to me. I'm just looking forward to getting as many matches as possible."

Bencic will not be joining her in the next round, as she became the highest seed to be eliminated on the day in a 6-3 6-4 defeat to Kristina Mladenovic.

The two played each other under two weeks ago in the first round of the Madrid Open, with Bencic victorious, but Mladenovic got her revenge as she capitalised on her opponent's seven double faults.

Like Tig, Sloane Stephens was also competing as a lucky loser as she came up against compatriot Madison Keys, though the outcome was no different.

Keys claimed only her second win in six meetings with Stephens but had to come from behind as she eventually clinched it 4-6 6-2 7-5 after two-and-a-half hours on court to set up a clash with 15th seed Iga Swiatek.

Elise Mertens, the 14th seed, was also dumped out of the competition, losing out 4-6 6-2 6-3 to Veronika Kudermetova, whom she had beaten in straight sets in their three WTA Tour contests before this one.

Veteran Kazakh Yaroslava Shvedova, ranked 665 in the world, awaits top seed Ashleigh Barty after the 33-year-old showed character to fight back and beat Martina Trevisan 0-6 7-6 (7-4) 7-6 (8-6), while Nadia Podoroska set up a second-round clash with Serena Williams after seeing off Laura Siegemund 2-6 7-6 (7-3) 6-1.

Andy Murray will make his competitive comeback at the Internazionali d'Italia this week after he and Liam Broady were entered into the men's doubles as alternates.

Murray has not played in a tournament since losing to Andrey Rublev in the second round in Rotterdam in March due to a groin injury.

The three-time grand slam champion flew to Rome to step up his preparation for a return, practicing with world number one Novak Djokovic and Diego Schwartzman on Sunday.

Murray will also make an unexpected doubles appearance, partnering fellow Brit Broady at the Foro Italico after Hubert Hurkacz and Felix Auger-Aliassime withdrew.

They will face Australian duo Max Purcell and Luke Saville for a place in the second round in the Eternal City on Wednesday.

Murray has entered qualifying for the French Open as he waits to discover whether he will be handed a wildcard for the second major of the year, which starts on May 30.

The former world number one is also hoping to receive a wildcard to play in Geneva or Lyon next week.

Scot Murray confirmed on Monday he will play at the Queen's Club Championships in June.

Novak Djokovic and Rafael Nadal learned their round of 32 opponents after Monday's action at the Internazionali BNL d'Italia in Rome.

Taylor Fritz will be hoping for a first win over world number one Djokovic at the fourth attempt after recovering from 1-3 down in the first set to defeat Monte Carlo semi-finalist Dan Evans 6-3 6-2.

"We played twice on clay in 2018, in Monte-Carlo and Madrid," the American said, having bounced back from two down to take Djokovic to five sets in this year's Australian Open.

"I got beaten pretty bad those two times. I feel better prepared to play him now, after the match in Australia."

Italian teenager Jannik Sinner continued his superb form to set up a meeting with Nadal, a nine-time winner in the Italian capital.

Sinner dispatched Ugo Humbert 6-2 6-4 in 90 minutes for his 20th win of the season and will now look to improve upon a straight-sets loss to Nadal at Roland Garros last October.

World number 27 Aslan Karatsev matched Sinner's 2021 haul by overcoming Miomir Kecmanovic 7-6 (7-2) 6-4 and is up next for Daniil Medvedev.

Marin Cilic will take on fifth seed Stefanos Tsitsipas after battling to a 4-6 6-2 6-3 triumph over Alexander Bublik, while Andrey Rublev and Dominic Thiem – also the beneficiaries of byes – will face Jan-Lennard Struff and Marton Fucsovics respectively after their straight-sets wins over lucky losers Aljaz Bedene and Yoshihito Nishioka.

The most notable casualty in Monday's round one action was Hubert Hurkacz who, who retired at 6-4 2-0 down to Italian wildcard Lorenzo Musetti.

Petra Kvitova recovered from a poor start to beat Magda Linette in the first round of the Internazionali BNL d'Italia on Monday.

Linette took just 31 minutes to win the first set in Rome, but world number 10 Kvitova responded superbly to win 1-6 6-0 6-2.

Two-time grand slam champion Kvitova racked up 16 unforced errors in the first set, yet rallied like the great competitor she has proved to be for so long to ensure she will face Vera Zvonareva - conqueror of Christina McHale - in the second round.

The 11th seed from the Czech Republic said: "The first set I started very badly. I was missing almost everything. On the court... [the ball] was bouncing everywhere as well. A little bit windy. I just had to get used to probably everything.

"The beginning of the second set when finally I held my serve and broke her serve, I think since then it was much, much better."

French Open champion Iga Swiatek advanced when Alison Riske retired at 5-4 down in the first set due to a recurrence of a left foot injury.

Swiatek, who will take on Sloane Stephens or Madison Keys in the second round, made 18 unforced errors but had won four games in a row from 4-1 down when the American was unable to continue. 

Coco Gauff battled past Yulia Putintseva 7-5 4-6 6-4 to set up a meeting with 17th seed Maria Sakkari  - who fended off qualifier Polona Hercog 7-6 (8-6) 3-6 6-2.

Amanda Anisimova will do battle with Elina Svitolina, a winner of this tournament twice, after defeating Wang Qiang 7-5 6-3. Jessie Pegula, Jennifer Brady and Petra Martic were among the other winners on day one.

Former world number one Andy Murray will play at the Queen's Club Championships in June.

Murray has won five singles titles at the event and claimed the doubles title with Feliciano Lopez two years ago just months after undergoing hip surgery.

The three-time major champion last played in Rotterdam in early March, where he was beaten in straight sets by Andrey Rublev in the last 16.

Murray has twice gone on to win Wimbledon after success at the traditional curtain-raiser in London – in 2013 and 2016 – and is relishing the opportunity to play in front of a home crowd again.

"It's been such a difficult time for everyone and it will be great to play in front of home fans in Britain again," Murray said.

"The tournament at Queen's has always meant a lot to me – it's where I won my first ATP match, I've won the singles at Queen's more than any other in my career, and I'll never forget our doubles title in 2019. I can't wait to get back out there."

Lopez is also the reigning singles champion, having beaten Gilles Simon in three sets to become the oldest winner of the event at the age of 37.

The tournament was cancelled last year due to the coronavirus pandemic.

Alexander Zverev ended a three-year wait for an ATP Masters 1000 title as he rallied to beat Matteo Berrettini in the Madrid Open final on Sunday.

The German had to do it the hard way at La Caja Magica over the past week, having previously seen off five-time winner Rafael Nadal and Dominic Thiem en route to the showpiece.

He was in a spot of bother against his Italian opponent at the end of a gripping first set that Berrettini took in a tie-break, Zverev's efforts in coming back from 5-0 down and earning a set point ultimately for nothing.

Berrettini eventually sealed the lead with his fourth set point but Zverev played with renewed focus at the start of the second, taking full advantage of a succession of mistakes with the score at 4-4 to force a decider.

Zverev's greater endurance in rallies then paid dividends early in the third as he broke to go 3-2 up, and Berrettini only won one more game as the German triumphed 6-7 (10-8) 6-4 6-3 to win the tournament for a second time.

Speaking afterwards, he said: "It is great [to win this title], especially after losing my last three finals I played at Masters 1000 events. This is definitely special and I just want to enjoy this one.

"[Berrettini's] game style showed it all. I didn't play anybody this week that can serve 235[km/h] on clay and serve 230km/h kick serves.

"It definitely was a different match and I am extremely happy right now."

On competing at the Internazionali d'Italia next, he added: "Rome is also an event I like and enjoy, so I hope I can perform [in] the same way as I did here and we will see how it goes there. I feel awesome."

This was the first time Zverev has beaten three or more top-10 players in a single competition since his ATP Finals victory in 2018.

Viktorija Golubic won the L'Open 35 de Saint-Malo on Sunday after a straight-sets win over Jasmine Paolini.

A finalist in Lyon and Monterrey in March, the world number 84 claimed a second career WTA125K singles title after a 6-1 6-3 triumph in 67 minutes.

Golubic held her nerve at the key moments in a close contest, landing 75 per cent of first serves and saving five of six break points.

Paolini threatened to make more of a contest in the second set after finally breaking, but the Italian dropped serve with her very next game and saw momentum slip away.

It was Golubic's first title since defeating Jennifer Brady at this level at Indian Wells two years ago.

Matteo Berrettini will take on Alexander Zverev in the Madrid Open final on Sunday after overcoming Casper Ruud 6-4 6-4 in the last four. 

Eighth seed Berrettini has enjoyed a superb debut tournament in the Spanish capital, the 25-year-old dropping just one set on his way to becoming the first Italian to make the Madrid Open final. 

Berrettini, who won the Serbia Open last month, is just the third Italian ATP Masters 1000 finalist since the series was established in 1990, after Fabio Fognini and Jannik Sinner. 

"It's a great, unbelievable feeling, especially coming from Monte Carlo where I wasn't feeling that good," Berrettini said in quotes reported by the ATP website. 

"I won in Belgrade and now I'm in the final, so I'm really looking forward to playing against Sascha [Zverev]. I hope I enjoy it tomorrow the way I enjoyed tonight.

"I saw him [Zverev], he's playing really good. He's solid. He moves well. For his height, he's really good. He serves well. I mean, he's in the final. He beat Rafa [Nadal] and Dominic [Thiem], probably the best players on clay.

"It's going to be a challenging match, but I'm in the finals. I guess the best two guys are going to play each other."

Berrettini returned supremely throughout Saturday's match, nullifying Ruud's usually potent serve, and believes his aggressive approach was key to victory.

"My serve is my weapon, but today I think I returned a lot and I put pressure on him," Berrettini said. "I was just playing more aggressive. He's kind of like me, he likes to run around the forehand and play with spin. But I guess today I was playing better than him.

"The other time he beat me, so it's always a great fight against him. He reached three semi-finals in a row so he was feeling confident. I guess that's why I'm maybe even more happy with my win today."

In the earlier semi-final, Zverev followed up his famous win over home favourite and 20-time grand slam champion Rafael Nadal in the previous round by defeating Dominic Thiem.

Austrian Thiem had won the last four meetings between the two, including in last year's Australian Open semi-final and the US Open decider, where he came from two sets down to win in an incredible fifth-set tie-break.

However, Zverev was not to be denied this time, a 6-3 6-4 result keeping him on course for a repeat of his 2018 triumph at the event in the Spanish capital.